Results 161 to 170 of about 8,449,566 (292)

Brain viral reservoir seeding and neurological metabolic dysregulation in early‐life immunodeficiency virus infection

Brain Pathology, Volume 36, Issue 6, November 2026.
Brain viral reservoirs were undetectable in neonatal SIV during the first 3 days post infection; antiretroviral therapy (ART) at 3 dpi prevented brain reservoir seeding and normalized metabolic function, highlighting the necessity of very early treatment to protect the developing CNS.
Li Ma, Robert Blair, Yao‐Zhong Liu, Xiaolei Wang, Eunice Vincent, Christopher Yu, Lara A. Doyle‐Meyers, Cissy Zhang, Ahmad Saied, Anne Le, Ronald S. Veazey, Qigui Yu, Huanbin Xu   +12 more
wiley   +1 more source

Is use of antiretroviral therapy among homosexual men associated with increased risk of transmission of HIV infection? [PDF]

, 2003
Background/objective: There is concern that use of highly active antiretroviral therapy (HAART) may be linked to increased sexual risk behaviour among homosexual men.
Hart, GJ, Stephenson, Jodie, Copas, AJ, Davidson, OR, Mercer, C. H., Imrie, John, Williams, IG, Williams, I. G., Davis, MMD, Davis, M, Imrie, J, Copas, A. J., Black, S, Hart, G, Davidson, O. R., Stephenson, JM, Mercer, C   +16 more
core  

Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy.

Proceedings of the National Academy of Sciences of the United States of America, 1997
Tae-Wook Chun, L. Stuyver, Stephanie B. Mizell, L. Ehler, J. Mican, M. Baseler, A. Lloyd, M. Nowak, A. Fauci   +8 more
semanticscholar   +1 more source

Evaluating Harm Reduction Advice From Large Language Models

Drug and Alcohol Review, Volume 45, Issue 7, November 2026.
ABSTRACT Introduction Large language models (LLM) and generative Artificial Intelligence are increasingly providing health information. We have applied a novel method to evaluate the harm reduction information generated by popular LLMs. We focused on the filtration of oral medications for injection and the availability of local harm reduction services.
Khy Choo, Nathan Smith, Bernadette Ward, Robert M. Lundin   +3 more
wiley   +1 more source

Medicinal Chemistry Aspects of Thiazole and Thiazolidine Derivatives as Fundamental Building Blocks to Design New NNRTIs Against HIV‐1 Reverse Transcriptase

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
HIV‐1 reverse transcriptase (HIV‐1 RT) is a polymerase enzyme and a key target in HIV‐1 therapy. The discovery of selective HIV‐1 RT inhibitors has highlighted thiazole scaffolds and their derivatives, thiazolidine‐2‐one and thiazolidine‐2,4‐dione, as promising structures for the rational design of novel non‐nucleoside reverse transcriptase inhibitors (
José Arion da Silva Moura, Matheus Vinicius Guimarães de Melo, Diane Regis Santos do Nascimento, Thaynara Paula Warren Bezerra, Mathieu Métifiot, Patricia Recordon‐Pinson, Maira Galdino da Rocha Pitta, Marina Galdino da Rocha Pitta, Michelly Cristiny Pereira, Marie‐Line Andreola   +9 more
wiley   +1 more source

The Effects of Compulsory Licensing: A Case Study of HIV Drugs

Health Economics, Volume 35, Issue 10, Page 1427-1434, October 2026.
ABSTRACT Compulsory licensing is a legal mechanism that allows governments the use of patented medicines without the owner's consent, subject to conditions and compensation, to meet public‐health needs. Despite its policy relevance and increasing use, empirical evidence on its market effects remains limited.
Nicolau Martin‐Bassols, Miquel Serra‐Burriel, Kerstin Noelle Vokinger   +2 more
wiley   +1 more source

Mucosal‐Associated Invariant T Cells in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao, Feng‐Mi Ou, Dan Liang, Yang Gao, Qing‐Qing Li, Yi‐Qun Kuang   +5 more
wiley   +1 more source

Do non-nucleoside reverse transcriptase inhibitors contribute to lipodystrophy? [PDF]

, 2005
Lipodystrophy complications, including lipoatrophy (pathological fat loss) and metabolic complications, have emerged as important long-term toxicities associated with antiretroviral therapy in the current era. The wealth of data that has accumulated over
Nolan, D.
core  

The impact of isoniazid preventative therapy and antiretroviral therapy on tuberculosis (TB) in HIV-infected children in a high TB incidence setting [PDF]

, 2011
The aim of this study is to investigate the combined effect of IPT [INH preventative therapy] and ART [antiretroviral therapy] on TB incidence in HIV-infected children.
Frigati, Lisa Jane
core   +1 more source

Mortality in the Highly Active Antiretroviral Therapy Era: Changing Causes of Death and Disease in the HIV Outpatient Study

Journal of Acquired Immune Deficiency Syndromes, 2006
F. Palella, R. Baker, A. Moorman, J. Chmiel, K. Wood, J. Brooks, S. Holmberg   +6 more
semanticscholar   +1 more source