Results 1 to 10 of about 3,216,105 (293)

Thyroid Autoimmunity and Function after Treatment with Biological Antirheumatic Agents in Rheumatoid Arthritis. [PDF]

Front Endocrinol (Lausanne), 2017
With the increased pro-inflammatory response in both rheumatoid arthritis and thyroid autoimmune diseases, treatment with biological antirheumatic agents (BAAs) of the former may affect the course of the latter. In hepatitis C and cancer patients, treatment with biological agents substantially increases the risk of developing thyroid autoimmunity.
Bliddal S, Borresen SW, Feldt-Rasmussen U.   +2 more
europepmc   +10 more sources

Diabetes-Modifying Antirheumatic Drugs: The Roles of DMARDs as Glucose-Lowering Agents [PDF]

Medicina, 2022
Systemic inflammation represents a shared pathophysiological mechanism which underlies the frequent clinical associations among chronic inflammatory rheumatic diseases (CIRDs), insulin resistance, type 2 diabetes (T2D), and chronic diabetes complications,
Marco Infante, Nathalia Padilla, Rodolfo Alejandro, Massimiliano Caprio, David Della-Morte, Andrea Fabbri, Camillo Ricordi   +6 more
doaj   +6 more sources

Comparative Risk of Alzheimer Disease and Related Dementia Among Medicare Beneficiaries With Rheumatoid Arthritis Treated With Targeted Disease-Modifying Antirheumatic Agents. [PDF]

JAMA Netw Open, 2022
Key Points Question Is use of targeted disease-modifying antirheumatic drugs associated with risk of Alzheimer disease and related dementia (ADRD)? Findings In this cohort study including 22 569 propensity score–matched patient pairs, initiation of ...
Desai RJ, Varma VR, Gerhard T, Segal J, Mahesri M, Chin K, Horton DB, Kim SC, Schneeweiss S, Thambisetty M.   +9 more
europepmc   +3 more sources

Antirheumatic agents in covid-19: is IL-6 the right target? [PDF]

Annals of the Rheumatic Diseases, 2020
The letter of Monti et al 1 on covid-19 in patients with chronic arthritis treated with immunosuppressive therapies stimulates some considerations. The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infects cells through the ACE-2 receptor, which is highly expressed in both the lung and the heart. Besides direct tissue injury, SARS-CoV-2
Pier Leopoldo Capecchi, Pietro Enea Lazzerini, Luca Volterrani, Maria Antonietta Mazzei, Barbara Rossetti, Giacomo Zanelli, David Bennett, Elena Bargagli, Federico Franchi, Matteo Cameli, Serafina Valente, Luca Cantarini, Bruno Frediani   +12 more
semanticscholar   +7 more sources

Effects of antirheumatic agents on cytokines [PDF]

Seminars in Arthritis and Rheumatism, 1996
A review of the literature concerning the effects of traditional antirheumatic drugs on cytokines and the cytokine and anticytokine approaches already used in the therapy of rheumatoid arthritis (RA) is presented. Many antirheumatic drugs are capable of cytokine modulation in vitro. Corticosteroids inhibit the transcription of a broad spectrum of genes
Pilar Barrera, A M Boerbooms, Leo B. A. Van De Putte, J.W.M. van der Meer   +3 more
semanticscholar   +7 more sources

Studies on antirheumatic agents. 3-Benzoylpropionic acid derivatives.

Chemical and Pharmaceutical Bulletin, 1988
AbstractThe acetophenones (I) and glyoxylic acid (II) are combined to give the α,β‐unsaturated acids (III) which react with thioacetic acid (IV), producing the adducts (V).
Kazuya Kameo, Kunio Ogawa, Kimiyo Takeshita, Shiro Nakaike, Kazuyuki Tomisawa, K. SOTA   +5 more
semanticscholar   +7 more sources

Antirheumatic Agents. I. Novel Methotrexate Derivatives Bearing an Indoline Moiety.

Chemical and Pharmaceutical Bulletin, 1996
Various novel methotrexate (MTX) derivatives bearing an indoline moiety were synthesized and tested for biological activities using human peripheral blood mononuclear cell (hPBMC) and human synovial cells (hSC) derived from patients with rheumatoid arthritis (RA).
Hiroharu Matsuoka, Nobuaki Kato, K. TSUJI, Noriaki Maruyama, Hiroshi Suzuki, Masahiko Mihara, Yasuhisa Takeda, Keiichi Yano   +7 more
semanticscholar   +6 more sources

Effect of Benzylidene Derivative (Novel Antirheumatic Agent) on Chondrocyte Metabolism.

Journal of Pharmacobio-Dynamics, 1992
The effects of protocatechualdehyde (PAL), one of the metabolites of 3,4-diacetoxy benzylidene diacetate (ACP), on proteoglycan metabolism and secretion of interleukin 1 (IL-1) like activity (lymphocyte activating factor; LAF activity) were studied using rabbit articular chondrocytes culture under phorbol myristate acetate (PMA) and Ca2+ ionophore ...
Koju Watanabe, Fumihiko Kimura, Masayuki Shinmei   +2 more
openalex   +5 more sources

Evaluation of impaired growth plate development of long bones in skeletally immature mice by antirheumatic agents. [PDF]

J Orthop Res, 2021
Caron MMJ, van Rietbergen B, Castermans TMR, Haartmans MJJ, van Rhijn LW, Welting TJM, Witlox AMA.   +6 more
europepmc   +3 more sources

Use of healthcare administrative claims data in observational studies of antirheumatic drug effects on pregnancy outcomes: A scoping review. [PDF]

PLoS ONE
The safety of antirheumatic drugs in pregnancy and their impact on maternal and neonatal outcomes are understudied. Despite pregnant individuals being excluded from clinical trials, their continued use of medications raises the importance of addressing ...
Shenthuraan Tharmarajah, Araniy Santhireswaran, Yasmeen Ameeriar, Lisa M McCarthy, Dharini Mahendira, Howard Berger, Mina Tadrous, Sara J T Guilcher   +7 more
doaj   +2 more sources