Thyroid Autoimmunity and Function after Treatment with Biological Antirheumatic Agents in Rheumatoid Arthritis. [PDF]
Front Endocrinol (Lausanne), 2017 With the increased pro-inflammatory response in both rheumatoid arthritis and thyroid autoimmune diseases, treatment with biological antirheumatic agents (BAAs) of the former may affect the course of the latter.
Bliddal S +2 more
europepmc +10 more sources
Diabetes-Modifying Antirheumatic Drugs: The Roles of DMARDs as Glucose-Lowering Agents [PDF]
Medicina, 2022 Systemic inflammation represents a shared pathophysiological mechanism which underlies the frequent clinical associations among chronic inflammatory rheumatic diseases (CIRDs), insulin resistance, type 2 diabetes (T2D), and chronic diabetes complications,
Marco Infante +6 more
doaj +6 more sources
Comparative Risk of Alzheimer Disease and Related Dementia Among Medicare Beneficiaries With Rheumatoid Arthritis Treated With Targeted Disease-Modifying Antirheumatic Agents. [PDF]
JAMA Netw Open, 2022 Key Points Question Is use of targeted disease-modifying antirheumatic drugs associated with risk of Alzheimer disease and related dementia (ADRD)? Findings In this cohort study including 22 569 propensity score–matched patient pairs, initiation of ...
Desai RJ +9 more
europepmc +3 more sources
Antirheumatic agents in covid-19: is IL-6 the right target? [PDF]
Annals of the Rheumatic Diseases, 2020 The letter of Monti et al 1 on covid-19 in patients with chronic arthritis treated with immunosuppressive therapies stimulates some considerations. The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infects cells through the ACE-2 receptor,
Pier Leopoldo Capecchi +12 more
semanticscholar +7 more sources
Effects of antirheumatic agents on cytokines [PDF]
Seminars in Arthritis and Rheumatism, 1996 A review of the literature concerning the effects of traditional antirheumatic drugs on cytokines and the cytokine and anticytokine approaches already used in the therapy of rheumatoid arthritis (RA) is presented. Many antirheumatic drugs are capable of cytokine modulation in vitro. Corticosteroids inhibit the transcription of a broad spectrum of genes
Pilar Barrera +3 more
semanticscholar +7 more sources
Studies on antirheumatic agents. 3-Benzoylpropionic acid derivatives.
Chemical and Pharmaceutical Bulletin, 1988 AbstractThe acetophenones (I) and glyoxylic acid (II) are combined to give the α,β‐unsaturated acids (III) which react with thioacetic acid (IV), producing the adducts (V).
Kazuya Kameo +5 more
semanticscholar +7 more sources
Antirheumatic Agents. I. Novel Methotrexate Derivatives Bearing an Indoline Moiety.
Chemical and Pharmaceutical Bulletin, 1996 Various novel methotrexate (MTX) derivatives bearing an indoline moiety were synthesized and tested for biological activities using human peripheral blood mononuclear cell (hPBMC) and human synovial cells (hSC) derived from patients with rheumatoid arthritis (RA).
Hiroharu Matsuoka +7 more
semanticscholar +6 more sources
Effect of Benzylidene Derivative (Novel Antirheumatic Agent) on Chondrocyte Metabolism.
Journal of Pharmacobio-Dynamics, 1992 The effects of protocatechualdehyde (PAL), one of the metabolites of 3,4-diacetoxy benzylidene diacetate (ACP), on proteoglycan metabolism and secretion of interleukin 1 (IL-1) like activity (lymphocyte activating factor; LAF activity) were studied using rabbit articular chondrocytes culture under phorbol myristate acetate (PMA) and Ca2+ ionophore ...
Koju Watanabe +2 more
openalex +5 more sources
Modification of proinflammatory cytokine production by the antirheumatic agents tenidap and naproxen. A possible correlate with clinical acute phase response. [PDF]
Journal of Immunology, 1992 The cytokines IL-6, IL-1, and TNF play a key role in the pathogenesis of rheumatoid arthritis (RA) and initiate hepatic serum amyloid A (SAA) expression after injury.
Jean D. Sipe, Laura M. Bartle, L D Loose
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Evaluation of impaired growth plate development of long bones in skeletally immature mice by antirheumatic agents. [PDF]
J Orthop Res, 2021 Caron MMJ +6 more
europepmc +3 more sources