Results 261 to 270 of about 131,722 (303)

History of Antisense Oligonucleotides

2003
Biological science is a rapidly flowing experimental stream, at times encountering a dam that impedes further progress. At such a pomt, a single crack may induce a major breakthrough Discovery of the double helical structure of DNA in 1953 (1) caused such an event, with flooding of new information into the area now known as molecular biology.
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Antisense Oligonucleotides as Research Tools

2003
The use of antisense oligonucleotides as both research tools and therapeutic molecules has emerged as a powerful alternative to small molecule inhibitors. Antisense oligonucleotides are short pieces of chemically modified DNA designed to hybridize to specific mRNA sequences present in the target gene.
J K, Taylor, S R, Cooper, N M, Dean
openaire   +2 more sources

Antisense oligonucleotide strategies in physiology

Molecular and Cellular Endocrinology, 1994
Antisense oligonucleotides can inhibit gene expression in living cells by binding to complementary sequences of DNA, RNA or mRNA. The mechanisms include inhibition of RNA synthesis, RNA splicing, mRNA export, binding of initiation factors, assembly of ribosome subunits and of sliding of the ribosome along the mRNA coding sequence.
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Antisense Oligonucleotides

Accounts of Chemical Research, 1995
Alain De Mesmaeker, Robert Haener, Pierre Martin, Heinz E. Moser   +3 more
openaire   +1 more source

Antisense technology: an overview and prospectus

Nature Reviews Drug Discovery, 2021
Stanley T Crooke, Xue-Hai Liang, Brenda F Baker   +2 more
exaly  

Antisense (Oligonucleotides)

2006
E KOLLER, N DEAN
  +4 more sources

Antisense oligonucleotide therapeutics

Expert Opinion on Investigational Drugs, 1999
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Immunomodulation by cytokine antisense oligonucleotides.

European cytokine network, 1995
The cytokine network is involved in normal immune reaction and in the progression of several pathologies. Antisense (AS) oligonucleotides, which allow specific inhibition of expression of proteins, offer a new methodology to investigate this complex network. This review focuses on the use of AS to modulate cytokine expression.
Lefebvre d'Hellencourt, Christian, Diaw, L., Guenounou, M.   +2 more
openaire   +2 more sources

Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS

New England Journal of Medicine, 2022
Gen Sobue, Adriano Chio, Philip Van Damme   +2 more
exaly  

Counteracting chromatin effects of a splicing-correcting antisense oligonucleotide improves its therapeutic efficacy in spinal muscular atrophy

Cell, 2022
Luciano E Marasco, Gwendal Dujardin, Rui Sousa-Luís   +2 more
exaly