Ethnopharmacology- and Chemotaxonomy-Guided Evaluation of <i>Apuleia leiocarpa</i> Bark and Leaf Extracts against Oropouche, Mayaro, Chikungunya, and Zika Viruses. [PDF]
de Sarges MRV +10 more
europepmc +1 more source
Carrier‐free self‐assembled nanomedicine for combination‐therapy of acute myeloid leukemia
CPDS combines drugs with three different mechanisms of action to achieve a multi‐mechanism combination therapy for AML by directly killing tumor cells and activating anti‐tumor immunity. Abstract As the main acute myeloid leukemia (AML) clinical treatment, the chemotherapy alone cannot meet the clinical therapeutic needs due to the high heterogeneity ...
Meihong Chai +14 more
wiley +1 more source
Discovery of Cetaben as a Novel Antiviral Agent Against Porcine Epidemic Diarrhea Virus From a Cholesterol-Lowering Compound Library. [PDF]
Li Y +11 more
europepmc +1 more source
Ecology and evolution of pyrazines in insects
ABSTRACT Chemical communication is the oldest and most widespread form of signalling among and within organisms. Among the many compounds involved in such communication, pyrazines – nitrogen‐containing heterocyclic molecules – are especially intriguing due to their widespread occurrence across the tree of life, from bacteria and fungi to insects and ...
Zowi Oudendijk +2 more
wiley +1 more source
From Food Waste to Valorized Nanomaterials: Sustainable Green Synthesis and Biomedical Applications
Food waste‐derived biomolecules act as natural reducing and stabilizing agents for the green synthesis of functional NPs with applications in antimicrobial systems, food packaging, biomedical technologies, and environmental remediation. ABSTRACT Food waste is a global issue, with billions of tons discarded and unutilized annually, causing economic ...
Siddhraj Rajput +8 more
wiley +1 more source
Stress granules at the crossroads of retroviral replication and antiviral immunity: mechanisms and therapeutic opportunities. [PDF]
Akbarin MM, Farjami Z, Álvarez HR.
europepmc +1 more source
The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik +3 more
wiley +1 more source
Divergent HIV-1 Restriction Phenotypes of IFITMs Expressed in Target Cells and Incorporated into Virions. [PDF]
Verma S +5 more
europepmc +1 more source
ProTides for Antiviral Activity Beyond Liver Cells
A strategy for obtaining prodrugs of antiviral nucleotides with broad tissue activity is presented that relies on cycloalkyl or cycloalkylalkyl esters, improving uptake and esterase cleavage, and producing nanomolar inhibitors in kidney, colon, and lung cells.
Felix Goebel +5 more
wiley +1 more source

