Results 111 to 120 of about 484,133 (345)

Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease

open access: yesAdvanced Science, EarlyView.
This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Andrea Elia   +6 more
wiley   +1 more source

Single‐Mitochondrion ATP Profiling Directs Discovery of Targetable OXPHOS Dependency in Cancers

open access: yesAdvanced Science, EarlyView.
MitoATP‐nFCM integrates nano‐flow cytometry with fluorogenic probes (ATP/membrane potential) and antibodies to quantify mitochondrial metabolites and protein expression at single‐organelle resolution, exposing oxidative phosphorylation (OXPHOS)‐driven metabolic rewiring in cancers.
Xu Xiao   +7 more
wiley   +1 more source

JAAN JUNG AJALOO RADADEL [PDF]

open access: yesActa Historica Tallinnensia, 2001
Ants Viires
doaj   +1 more source

UBE2T‐Driven p53 Degradation Rewires Glycolysis to Orchestrate Lactylation‐Mediated CAFs Activation and ECM Deposition in Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
This study integrates multi‐omics to reveal the critical role of UBE2T in driving malignancy and stromal co‐evolution in PDAC. UBE2T potentiates glycolysis by regulating p53 degradation via a positive feedback loop, thereby promoting histone H3 lysine 18 lactylation in CAFs and stromal deposition. The UBE2T inhibitor PGG represents a potential strategy
Yong Ma   +16 more
wiley   +1 more source

Collective action in ant control: [PDF]

open access: yes
Leaf-cutting ants (Atta. cephalotes) represents a serious problem to farmers in many parts of Latin America and accounts of ants eating up a whole cassava plot or destroying one or more fruit trees overnight are not uncommon.
de la Cruz, Ana Milena   +3 more
core  

Ants: Mobile Finite State Machines [PDF]

open access: yes, 2013
Consider the Ants Nearby Treasure Search (ANTS) problem introduced by Feinerman, Korman, Lotker, and Sereni (PODC 2012), where $n$ mobile agents, initially placed at the origin of an infinite grid, collaboratively search for an adversarially hidden ...
Jara Uitto   +4 more
core  

OCIAD2 Stabilizes Integrin β1 Signaling Through SNX17‐Mediated Endosomal Recycling to Lipid Rafts and Modulates Cisplatin Response in HNSCC

open access: yesAdvanced Science, EarlyView.
This study identifies OCIAD2 as a critical regulator of cisplatin resistance in HNSCC. Mechanistically, OCIAD2 stabilizes integrin β1 through a direct physical interaction and facilitates its SNX17‐dependent endosomal recycling to lipid raft microdomains. Targeting OCIAD2 disrupts integrin β1 trafficking and significantly enhances cisplatin sensitivity,
Li Cui   +9 more
wiley   +1 more source

Aminal‐linked Covalent Organic Frameworks for Light Energy Upconversion

open access: yesAngewandte Chemie, EarlyView.
Aminal‐linked covalent organic frameworks incorporating anthracene units are introduced as solid‐state platforms for triplet–triplet annihilation upconversion. The crystalline materials retain chromophore electronic properties and exhibit fluorescence quantum yields of up to 40%.
Mateusz Brzeziński   +7 more
wiley   +2 more sources

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