CMG2/ANTXR2 regulates extracellular collagen VI which accumulates in hyaline fibromatosis syndrome [PDF]
Nature Communications, 2017 Hyaline fibromatosis syndrome (HFS) is a hereditary disease characterized by nodular cutaneous lesions and joint pain. Here Bürgiet al. show that CMG2/ANTXR2 regulates collagen VI abundance, with loss-of-function mutations promoting collagen VI ...
Paolo Bonaldo +2 more
exaly +11 more sources
Anthrax Susceptibility: Human Genetic Polymorphisms Modulating ANTXR2 Expression [PDF]
Toxins, 2015 Anthrax toxin causes anthrax pathogenesis and expression levels of ANTXR2 (anthrax toxin receptor 2) are strongly correlated with anthrax toxin susceptibility.
Zhang Zhang +11 more
doaj +4 more sources
Rare variant analyses validate known ALS genes in a multi-ethnic population and identifies ANTXR2 as a candidate in PLS [PDF]
BMC GenomicsBackground Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting over 300,000 people worldwide. It is characterized by the progressive decline of the nervous system that leads to the weakening of muscles which impacts physical ...
Tess D. Pottinger +15 more
doaj +7 more sources
Anthrax toxin receptor 2 determinants that dictate the pH threshold of toxin pore formation. [PDF]
PLoS ONE, 2007 The anthrax toxin receptors, ANTXR1 and ANTXR2, act as molecular clamps to prevent the protective antigen (PA) toxin subunit from forming pores until exposure to low pH. PA forms pores at pH approximately 6.0 or below when it is bound to ANTXR1, but only
Heather M Scobie +5 more
doaj +4 more sources
Anthrax toxin receptor 2 functions in ECM homeostasis of the murine reproductive tract and promotes MMP activity. [PDF]
PLoS ONE, 2012 Anthrax Toxin Receptor proteins function as receptors for anthrax toxin, however physiological activity remains unclear. To evaluate the biological role of Antxr2, we generated Antxr2-/- mice.
Claire V Reeves +6 more
doaj +2 more sources
Anthrax toxin receptor 2-dependent lethal toxin killing in vivo. [PDF]
PLoS Pathogens, 2006 Anthrax toxin receptors 1 and 2 (ANTXR1 and ANTXR2) have a related integrin-like inserted (I) domain which interacts with a metal cation that is coordinated by residue D683 of the protective antigen (PA) subunit of anthrax toxin. The receptor-bound metal
Heather M Scobie +8 more
doaj +3 more sources
Investigating the Influence of ANTXR2 Gene Mutations on Protective Antigen Binding for Heightened Anthrax Resistance. [PDF]
Genes (Basel)Bacillus anthracis is the bacterium responsible for causing the zoonotic disease called anthrax. The disease presents itself in different forms like gastrointestinal, inhalation, and cutaneous. Bacterial spores are tremendously adaptable, can persist for extended periods and occasionally endanger human health. The Anthrax Toxin Receptor-2 (ANTXR2) gene
Archana CA +9 more
europepmc +4 more sources
Antxr2-mediated fine-tuning of Collagen VI ensures skeletal muscle function
ABSTRACT Tissue function relies on the extracellular matrix (ECM) that surrounds cells, providing structural and biochemical support. The complex ECM composition depends on an adequately tuned balance between the deposition and degradation of each of its components.
Metti S +17 more
europepmc +3 more sources
Endothelial-Specific Ablation of ANTXR1, ANTXR2, and MMP14 in Retinal Angiogenesis [PDF]
, 2022 In order to determine the angiogenic requirement(s) for ANTXR1, ANTXR2, and MMP14 by removing these genes pairwise specifically in endothelial, pericyte, and smooth muscle cells during sprouting angiogenesis. The mouse retina is a common model used to study sprouting angiogenesis.
Zari P Dumanian (14073630)
openaire +2 more sources
BMC Women's Health, 2023 Background Endometriosis, a common gynaecological disease in women, affects 10% of women of childbearing age. Among infertile women, this proportion is as high as 30–50%.
Yong Liu +8 more
doaj +3 more sources