Results 11 to 20 of about 345,692 (191)
Profilaktyka reaktywacji zakażeń HBV – rekomendacje grupy roboczej profilaktyki reaktywacji HBV [PDF]
, 2019 Reaktywacja zakażenia HBV jest istotnym problemem u chorych poddawanych terapiom, które poprzez działanie immunomodulujące wpływają na upośledzenie odporności przeciwwirusowej, takim jak: leczenie biologiczne (np.
Flisiak, Robert +7 more
core +3 more sources
Anti-TNF Therapy in Crohn’s Disease [PDF]
International Journal of Molecular Sciences, 2018 Crohn’s disease (CD) accounts for a variety of clinical manifestations or phenotypes that stem from chronic inflammation in the gastrointestinal tract. Its worldwide incidence is increasing including younger or childhood-onset of disease. The natural history of Crohn’s disease is characterized by a remitting and relapsing course that progresses to ...
Samuel O. Adegbola +4 more
openaire +5 more sources
New aspects of spondyloarthritis pathogenesis. Part III – arthritis, pathological bone remodeling [PDF]
, 2014 Spondyloarthritis (SpA) is a form of chronic inflammatory arthritis affecting axial and peripheral joints, which may be initiated by inflammation of joint subchondral bone marrow or enthesitis.
Ewa Kontny
core +3 more sources
International Journal of Molecular Sciences, 2021 Tumor necrosis factor alpha (TNF-α) was initially recognized as a factor that causes the necrosis of tumors, but it has been recently identified to have additional important functions as a pathological component of autoimmune diseases. TNF-α binds to two
Dan-in Jang +7 more
semanticscholar +1 more source
Death by TNF: a road to inflammation
Nature reviews. Immunology, 2022 Tumour necrosis factor (TNF) is a central cytokine in inflammatory reactions, and biologics that neutralize TNF are among the most successful drugs for the treatment of chronic inflammatory and autoimmune pathologies.
G. van Loo, M. Bertrand
semanticscholar +1 more source
TNF in the liver: targeting a central player in inflammation
Seminars in Immunopathology, 2022 Tumour necrosis factor-α (TNF) is a multifunctional cytokine. First recognized as an endogenous soluble factor that induces necrosis of solid tumours, TNF became increasingly important as pro-inflammatory cytokine being involved in the immunopathogenesis
G. Tiegs, A. Horst
semanticscholar +1 more source
Regulation of TNF-Induced Osteoclast Differentiation
Cells, 2021 Increased osteoclast (OC) differentiation and activity is the critical event that results in bone loss and joint destruction in common pathological bone conditions, such as osteoporosis and rheumatoid arthritis (RA).
Z. Yao, Stephen J. Getting, I. Locke
semanticscholar +1 more source
Rheumatology, 2009 The use of protein-based anti-TNF-alpha therapies such as antibodies and soluble TNF-alpha receptors is commonly associated with the induction of autoantibodies, whereas anti-TNF-induced lupus (ATIL) is rare. ATIL can occur with any of the available TNF inhibitors, but the frequency and clinical characteristics of ATIL vary between different drugs ...
Williams, Emma L. +2 more
openaire +3 more sources
TNF-mediated neuroinflammation is linked to neuronal necroptosis in Alzheimer's disease hippocampus
Acta Neuropathologica Communications, 2021 The pathogenetic mechanisms underlying neuronal death and dysfunction in Alzheimer’s disease (AD) remain unclear. However, chronic neuroinflammation has been implicated in stimulating or exacerbating neuronal damage.
A. Jayaraman +4 more
semanticscholar +1 more source
bioRxiv, 2020 The COVID-19 pandemic has caused significant morbidity and mortality. Currently, there is a critical shortage of proven treatment options and an urgent need to understand the pathogenesis of multi-organ failure and lung damage.
Rajendra Karki +15 more
semanticscholar +1 more source