Results 71 to 80 of about 345,692 (191)
TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation
Nature Cell Biology, 2018 The linear-ubiquitin chain assembly complex (LUBAC) modulates signalling via various immune receptors. In tumour necrosis factor (TNF) signalling, linear (also known as M1) ubiquitin enables full gene activation and prevents cell death.
É. Lafont +14 more
semanticscholar +1 more source
The most common dermatological manifestations of inflammatory bowel diseases [PDF]
, 2023 Inflammatory bowel diseases are increasingly common problem in clinical practice. This condition is caused by both the growing morbidity and more accurate and widely available diagnostic methods, affecting the rising recognition. It is worth ...
Branewska, Justyna +9 more
core +1 more source
Unleashing endogenous TNF-alpha as a cancer immunotherapeutic
Journal of Translational Medicine, 2018 Tumor necrosis factor (TNF)-alpha was originally identified in the 1970s as the serum mediator of innate immunity capable of inducing hemorrhagic necrosis in tumors.
S. Josephs +6 more
semanticscholar +1 more source
Zakażenia i nieswoiste zapalenia jelit [PDF]
, 2013 W artykule przedstawiono związek między zakażeniami bakteryjnymi, wirusowymi i pasożytniczymi a nieswoistymi chorobami zapalnymi jelit. Zaostrzenia wrzodziejącego zapalenia jelita grubego i choroby Leśniowskiego- Crohna mogą być wywołane przez różne ...
Bartnik, Witold
core +1 more source
Crohn's disease what we know about it, symptoms, diagnosis, treatment [PDF]
, 2023 Crohn's disease is a chronic disease. It most often begins between the ages of 15 and 35 and lasts a lifetime. The earliest radiographic findings are aphthous ulcers. It can cause mouth-to-anal lesions and extra-intestinal complications. Typical symptoms
Misiło, Adriana +2 more
core +1 more source
What kind of therapeutic solutions for Graves’ disease does modern medicine propose? - a review of the literature [PDF]
, 2023 Background: Graves' disease is responsible for 60-80% causes of hyperthyreosis. An important role in the pathogenesis is played by anti-TSHR immunoglobulins (TRAb), that stimulate TSH receptors leading to excessive hormone synthesis and release by the ...
Bakalarczyk, Rafał +9 more
core +1 more source
Small Molecules as Anti-TNF Drugs
Current Medicinal Chemistry, 2015 Tumor necrosis factor (TNF, TNF-α, cachectin) is a pleiotropic, proinflammatory cytokine with multiple biological effects, many of which are not yet fully understood. Although TNF was initially described as an anti-tumor agent more than three decades ago, current knowledge places it central to immune system homeostasis.
Richmond, Victoria +4 more
openaire +3 more sources
Farmakoterapia colitis ulcerosa w fazie zaostrzenia i remisji — drugi konsensus europejski (2012) [PDF]
, 2013 W artykule omówiono zasady farmakoterapii w różnych fazach colitis ulcerosa na podstawie drugiego konsensusu europejskiego opublikowanego w Journal of Crohn’s and Colitis w 2012 ...
Bartnik, Witold
core +1 more source
Hidradenitis suppurativa - current and promising non-surgical treatment [PDF]
, 2023 Introduction and purpose: Hidradenitis suppurativa (HS) also known as acne inversa is a chronic, inflammatory dermatosis with predilection to apocrine gland-rich regions.
Baran, Natalia +8 more
core +1 more source
Amyloidoza AA — przyczyny, diagnostyka, opcje terapeutyczne [PDF]
, 2018 AA amyloidosis is a complication of chronic diseases associated with the activation of acute phase reactants. The precursor of amyloid is the serum amyloid A.
Więsik-Szewczyk, Ewa
core +2 more sources