Results 111 to 120 of about 58,847 (249)

Remote Silyl Groups Enhance Hydrolytic Stability and Photocleavage Efficiency in Carbamates for Protein Release

open access: yesAngewandte Chemie International Edition, Accepted Article.
Photocleavable molecules are valuable tools for biological studies, enabling spatiotemporal activation of molecular functions within cellular environments. In particular, coumarin‐based photolytic molecules are useful because of their ability to flexibly tune the wavelength of photostimulation through their structural modifications.
Masahiko Yoshimura   +5 more
wiley   +1 more source

A Single‐Molecule Liposome Assay for Membrane Permeabilisation

open access: yesAngewandte Chemie International Edition, Accepted Article.
Cell membrane disruption is associated with numerous diseases and underlies the activity of various antimicrobial agents. The rapid screening of compounds capable of disrupting or permeabilising biological membranes is essential to the search for new therapeutic drugs.
Krzysztof Marek Bąk   +9 more
wiley   +1 more source

Building a Bridge Between Ambient MS and LC‐MS by Non‐Exhaustive Microdesorption

open access: yesAngewandte Chemie International Edition, Accepted Article.
Ambient mass spectrometry (AMS) offers rapid screening but faces challenges in analyzing complex samples due to high matrix effects and limited selectivity. The absence of a separation step can also lead to false positives due to the isomers or isobars.
Wei Zhou, Janusz Pawliszyn
wiley   +1 more source

Controlled Growth of Oligophenylene‐Structures on Graphene for Facile Secondary functionalization.

open access: yesAngewandte Chemie International Edition, Accepted Article.
Functionalization of graphene derivatives is a common approach to tune material properties for use in various applications. Due to the low reactivity of the unsaturated carbon lattice of graphene, not only are few chemical approaches suitable for successful functionalization, such as those involving highly reactive in situ formed radical species or ...
Christian Eberhard Halbig   +6 more
wiley   +1 more source

Prodrugs of the Archetypal Dynamin Inhibitor Bis‐T‐22

open access: yesChemMedChem, Volume 17, Issue 24, December 16, 2022., 2022
The Bis‐T series of compounds comprise some of the most potent inhibitors of dynamin GTPase activity yet reported, such as Bis‐T‐22 (2). The catechol moieties are believed to limit cell permeability, rendering these compounds largely inactive in cells.
Luke R. Odell   +6 more
wiley   +1 more source

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