Results 171 to 180 of about 150,161 (341)
ChemMedChem, EarlyView.Ubiquitin‐specific protease 7 (USP‐7) is a novel target for anticancer therapy. To further extend the structure–activity relationships of the previously USP‐7 inhibitor STIRUR‐41, a library of 5‐aminopyrazoles is reported. 1d shows a potency comparable to lead compound STIRUR‐41 and promising in silico and in vitro pharmacokinetic properties ...
Matteo Lusardi +9 more
wiley +1 more source
Remarks on the Treatment of Strangulated Hernia, Founded on Two Cases of False Anus after Herniotomy, in which the "Spur" was Removed by Dupuytren's Enterotome, and the Opening Closed by Suture [PDF]
, 1885 Howard Marsh
openalex +1 more source
ChemMedChem, EarlyView.The synthesis of a new series of 4,5‐dihydrothiazol‐2‐ylphenylpiperazine derivatives as serotoninergic ligands is described and tested for their affinity toward 5‐HT1A, 5‐HT2A,and 5‐HT2C and selected for further in vivo assays to determine their functional activity. The pharmacological studies highlight that among the developed derivatives, FG‐7 and FG‐
Giorgia Andreozzi +18 more
wiley +1 more source
Identification of a New Interesting BAG3 Modulator Able to Disrupt Cancer‐Related Pathways
ChemMedChem, Accepted Article.Continuing our research aimed at discovering new BAG3 modulators as attractive anticancer drug candidates, we performed a screening campaign on an in‐house library, including compounds featuring a large variety of scaffolds. The obtained results induced us to focus on the triazole moiety and, following a stepwise structural refinement of the scaffold ...
Dafne Ruggiero +10 more
wiley +1 more source
Lineage labeling with zebrafish hand2 Cre and CreERT2 recombinase CRISPR knock‐ins
Developmental Dynamics, EarlyView.Abstract Background The ability to generate endogenous Cre recombinase drivers using CRISPR‐Cas9 knock‐in technology allows lineage tracing, cell type‐specific gene studies, and in vivo validation of inferred developmental trajectories from phenotypic and gene expression analyses. This report describes endogenous zebrafish hand2 Cre and CreERT2 drivers
Zhitao Ming +14 more
wiley +1 more source
Dapagliflozin alleviates high‐fat‐induced obesity cardiomyopathy by inhibiting ferroptosis
ESC Heart Failure, Volume 12, Issue 2, Page 1358-1373, April 2025.Abstract Aim: Dapagliflozin (Dapa) is a novel hypoglycaemic agent with multiple cardiovascular protective effects, and it is widely used in treatment of heart failure patients, but whether it can improve obese phenotype of heart failure and its mechanism is still unclear.
Di Chen +7 more
wiley +1 more source
The Anal Position Index: A Simple Method to Define the Normal Position of the Anus in Neonate
Journal of Research in Medical Sciences, 2004 Background: The purpose of this study was to determine the normal position of anus using anal position index (API) and the modified measurement method and also to emphasize the importance of ectopic anus. Methods: This cross-sectional study was performed
H A Davari, M Nazem
doaj