Results 81 to 90 of about 338,477 (271)

Perioperative utilization of JAK inhibitors in Perianal Fistulizing Crohn's disease

JPGN Reports, EarlyView.
Abstract With the recent approval of small molecule drugs such as upadacitinib in adult inflammatory bowel disease (IBD), their utilization is becoming more common; however, there is limited data on perioperative risks or optimal timing of cessation and resumption to mitigate flares. Current recommendations suggest holding these medications for 14 days
Alexander Lyons, Lindsey Lawrence, Samantha Saul   +2 more
wiley   +1 more source

Pre-treatment tumour PET metrics and clinical outcomes of anal cancer in patients living with and without HIV

Acta Oncologica
Background/purpose: To investigate if pre-treatment tumour positron-emission tomography (PET) metrics’ prognostic efficacy changes with HIV or viral load (VL) in anal squamous cell carcinoma (ASCC).
Michael Pennock, N. Patrik Brodin, Christian Velten, Megi Gjini, Nitin Ohri, Chandan Guha, Shalom Kalnicki, Wolfgang A. Tome, Madhur K. Garg, Rafi Kabarriti   +9 more
doaj   +1 more source

A Multimodal Ultrasound Approach Combining Transperineal and Transrectal Shear Wave Elastography for Early Prediction of Stress Urinary Incontinence in Women

Journal of Ultrasound in Medicine, EarlyView.
Objectives This study aims to evaluate the diagnostic value of a novel multimodal approach combining transperineal ultrasound (TPUS), transrectal dual‐plane ultrasound, and shear wave elastography (SWE) in predicting stress urinary incontinence (SUI). Methods A total of 70 women diagnosed with SUI and 110 healthy controls were included.
Yidan Wang, Jing Feng, Jingyan Xie, Yang Yang, Yaping Wang, Yujuan Li, Jiajun Xu   +6 more
wiley   +1 more source

Granular cell tumor of anal border

Journal of Coloproctology, 2016
The objective of this report is to describe a case of granular cell tumor of the anal border and to review the most relevant topics of the literature on the subject.
Angelo Fontes Araújo, Igor Blohem Vasconcelos, Jadeilton Jipso de Souza Dias, Luciano Santana de Miranda Ferreira, Rodrigo Guimarães Andrade, Paulo César Boente Santos   +5 more
doaj   +1 more source

Mass spectrometry imaging of N‐linked glycans: Fundamentals and recent advances

Mass Spectrometry Reviews, EarlyView.
Abstract With implications in several medical conditions, N‐linked glycosylation is one of the most important posttranslation modifications present in all living organisms. Due to their nontemplate synthesis, glycan structures are extraordinarily complex and require multiple analytical techniques for complete structural elucidation.
Tana V. Palomino, David C. Muddiman
wiley   +1 more source

A Genome‐Wide Association Study of Colorectal Cancer Mortality Outcomes Among Individuals of African and Admixture Ancestry

Molecular Carcinogenesis, EarlyView.
ABSTRACT African Americans have the highest colorectal cancer (CRC) mortality rates in the United States. We performed the first genome‐wide association study (GWAS) of overall and CRC‐specific mortality among African Americans with incident CRC to identify genetic contributors to CRC outcomes.
Thomas Lawler, Jirong Long, Rene Welch, Irene Ong, Oluwatoyosi Ogunmuyiwa, Rida A. Khatri, Martha Shrubsole, Shaneda Warren Andersen   +7 more
wiley   +1 more source

Behavior of colorrectal cancer Amalia Simoni Clinical Surgical Teaching Hospital

Archivo Médico de Camagüey, 2019
Background: the large intestine extends from the cecum to the orifice of the anus. The colon is segment of the digestive system that with greater frequency is affected by tumors. Objective: to determine the behavior of colorectal cancer.
Yon Luis Trujillo-Pérez, Yosvany Rojas-Peláez, Bárbara Maite Carmenates-Álvarez, Ana Dianelis Reyes-Escobar, Marelen Pérez-Álvarez   +4 more
doaj  

Synthesis of Pyrido[2,3‐d]Azolopyrimidinones: Design and Epidermal Growth Factor Receptor‐Targeted Molecular Docking Toward Novel Anticancer Leads

ChemistryOpen, EarlyView.
New pyrido[2,3‐d]azolopyrimidinones were synthesized and evaluated as potent EGFR‐targeted anticancer leads. Molecular docking and cytotoxicity studies revealed strong receptor binding and submicromolar activity, highlighting this scaffold as a promising framework for future targeted drug development.
Sobhi M. Gomha, Sami A. Al‐Hussain, Basant Farag, AbdElAziz A. Nayl, Wesam Hussein, Abdelwahed R. Sayed, Magdi E. A. Zaki   +6 more
wiley   +1 more source

Emerging Triboelectric Nanogenerators for In‐Body Implantation

Small Methods, EarlyView.
This review explores functional implantable triboelectric nanogenerators in biomedical applications, discussing their mechanisms, electricity generation, and design approaches. To solve postimplantation challenges, four types of triboelectric nanogenerators (TENGs) are introduced: stretchable, bioadhesive, on‐demand biodegradable, and multiresponsive ...
Xiao Xiao, Xiangchun Meng, Yong Hyun Kwon, Yoojin Park, Sang‐Woo Kim   +4 more
wiley   +1 more source

Perianal squamous cell carcinoma with high-grade anal intraepithelial neoplasia in an HIV-positive patient using highly active antiretroviral therapy: case report

São Paulo Medical Journal
CONTEXT: Highly active antiretroviral therapy (HAART) has turned human immunodeficiency virus (HIV) infection into a chronic condition, and this has led to increased incidence of anal dysplasia among HIV-positive patients.
Sergio Carlos Nahas, Caio Sergio Rizkallah Nahas, Edesio Vieira da Silva Filho, Jose Eduardo Levi, Fabio Cesar Atui, Carlos Frederico Sparapan Marques   +5 more
doaj   +1 more source