Results 191 to 200 of about 3,066,169 (363)

Advanced Stem Cell Therapy: 3D‐Bioprinted Brain‐Like Transplants for Alzheimer's Disease‐Like Dementia

Advanced Science, EarlyView.
A tri‐component biomimetic bioink(gelatin/alginate/fibrinogen) is developed to protect cells in critical pathological environments in AD. Using this bioink, a 3D‐printed NPC construct optimized for hippocampal transplantation is provided to improve cell retention and differentiation in an AD‐like model. This approach enhances memory recovery and offers
Ke Gai, Yu Song, Dawen Gao, Qingning Nie, Xiao Luo, Caizhe Xu, Changhao Cai, Austin Smith, Xiang Li, Wei Shi, Lei Zhang, Wei Sun, Feng Lin   +12 more
wiley   +1 more source

Changes in emotional granularity under a population-level stressor predict social anxiety and depressive symptoms. [PDF]

J Res Adolesc
Liu S, Zabag R, Xu J, Wang Y, Deng W, Joormann J, Gadassi-Polack R.   +6 more
europepmc   +1 more source

Adaptive anxiety [PDF]

The Lancet Planetary Health, 2020
openaire   +3 more sources

Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors

Advanced Science, EarlyView.
Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen, Riya Gupta, Yosuke M. Morizawa, Yu Qin, Xingyu Du, Cynthia Pang, Osama Al‐Dalahmah, Maura B. Dupont, Guang Yang   +8 more
wiley   +1 more source

Wearable devices for anxiety assessment: a systematic review. [PDF]

Commun Med (Lond)
Elgendi M, Markov K, Liu H, De Vos M, Khalaf K, Khandoker A, Jelinek HF, Goswami D, Menon C.   +8 more
europepmc   +1 more source

Anxiety and Depression Among Patients with Predominantly Antibody Deficiencies and the Importance of Early Diagnosis

, 2021
Sait Yeşillik, Fevzi Demirel
openalex   +2 more sources

Subicular Astrocytes Govern Seizure‐Impaired Fear Memory

Advanced Science, EarlyView.
Astrocytes in dorsal subiculum act as a critical modulator of seizure‐associated cognitive dysfunction, operating through a Ca2+‐dependent adenosine‐linked astrocyte‐neuron signaling pathway that disrupts neuronal circuit homeostasis. This research highlights the potential of astrocyte‐targeted interventions as a therapeutic strategy, moving beyond the
Yuying Shao, Jing Xi, Yuhao Sun, Yulan Li, Zhisheng Li, Wangjialu Lu, Jialu Chen, Lin Yang, Fan Fei, Heming Cheng, Li Cheng, Cenglin Xu, Zhuo Huang, Vladimir Parpura, Yi Wang, Zhong Chen   +15 more
wiley   +1 more source

Impaired early visual categorization of fear in social anxiety

, 2019
Melissa Meynadasy, Kevin J. Clancy, Zijun Ke, Jessica Simon, Wei Wu, Wen Li   +5 more
openalex   +2 more sources

Estrogen withdrawal alters oxytocin signaling in the paraventricular hypothalamus and dorsal raphe nucleus to increase postpartum anxiety [PDF]

, 2020
Valerie L. Hedges, Elizabeth C. Heaton, Claudia Amaral, Lauren E. Benedetto, Clio L. Bodie, Breanna I. D’Antonio, Dayana R. Davila Portillo, Rachel H. Lee, Michael Levine, Emily C. O’Sullivan, Natalie P. Pisch, Shantal Taveras, Hannah Wild, Amy P. Ross, H. Elliott Albers, Laura E. Been   +15 more
openalex   +1 more source

Adenylyl Cyclase 8 in Dorsal CA1 Neurons Prevents Depressive‐Like Behaviors by Maintaining Neuronal Excitability and Glutamatergic Neurotransmission Through TIP39‐PTH2R Signaling

Advanced Science, EarlyView.
Depression, a prevalent neuropsychiatric disorder with unclear pathogenesis, involves dysfunctional adenylyl cyclase 8 (Adcy8) as a key risk factor. Chronic stress selectively reduces Adcy8 expression in the dorsal CA1 (dCA1) neurons. Depletion of Adcy8 in dCA1 excitatory neurons induces depressive‐like behaviors by impairing neuronal excitability and ...
Zi‐Jie Liu, Jia‐Rui Bi, Zong‐Yan Yu, Meng Tian, Zhi‐Yue Chen, Ran Wei, Miao‐Miao Wang, Hai‐Wei Zha, Yu‐Qing Zhang, Hong‐Jing Wang, Bang‐You Qiang, Shuang‐Shuang Sun, Xiao‐Juan Zhu, Wen‐Bing Chen, Dong Sun   +14 more
wiley   +1 more source