Results 141 to 150 of about 1,062,531 (360)
Advanced Science, EarlyView.This study identifies elevated taurocholic acid (TCA) in Major Depressive Disorder patients. Gut microbiome‐associated TCA impairs hippocampal neurogenesis, triggers microglia activation, and elicits depression‐like behavior in mice via the S1PR2. In patients, functional neuroimaging reveals that serum TCA levels correlate with altered functional ...
Xiaoying Cai +12 more
wiley +1 more source
Psychiatric Impact of Tuberous Sclerosis Complex and Utilization of Mental Health Treatment [PDF]
, 2018 Tuberous sclerosis complex (TSC) is a multi-system, neurocutaneous disorder with neuropsychiatric features known as TSC-associated neuropsychiatric disorders (TAND).
Mowrey, Kate
core +1 more source
Validity and Reliability of the Turkish Version of Generalized Anxiety Disorder Scale-Revised [PDF]
, 2021 Anıl Gündüz +8 more
openalex +1 more source
Advanced Science, EarlyView.CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong +5 more
wiley +1 more source
Advanced Science, EarlyView.The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang +15 more
wiley +1 more source
Social Anxiety Disorder and Mood Disorders Comorbidity [PDF]
Psikiyatride Güncel Yaklaşımlar, 2012 Social Anxiety Disorder is a common disorder leading functional impairment. The comorbidity between mood disorders with social anxiety disorder is relatively common. This comorbidity impacts the clinical severity, resistance and functionality of patients.
Zerrin Binbay, Ahmet Koyuncu
doaj
Generalized anxiety disorder, depressive symptoms and sleep quality during COVID-19 epidemic in China: a web-based cross-sectional survey [PDF]
, 2020 Yeen Huang, Ning Zhao
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Anxiety, Anxiety Disorders, Religion and Spirituality
Southern Medical Journal, 2007 The article provides a brief overview of the literature on religion and anxiety. Then, in a discussion of two case vignettes, an impression is given of how religious and spiritual issues interact with anxiety in the clinical (psychiatric) situation. In the final part it is indicated how these religious and spiritual issues may be addressed.
openaire +3 more sources
Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors
Advanced Science, EarlyView.Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen +8 more
wiley +1 more source