Results 151 to 160 of about 1,037,362 (313)

LncRNA THUMPD3‐AS1 Regulates Behavioral and Synaptic Structural Abnormalities in Schizophrenia via miR‐485‐5p and ARHGAP8

Advanced Science, EarlyView.
Schizophrenia (SCZ) is linked to synaptic structural deficits driven by dysregulated noncoding RNAs. Using the novel ceRNAxis pipeline, THUMPD3‐AS1/miR‐485‐5p/ARHGAP8 is identified as a key regulator of actin cytoskeletal remodeling through noncanonical RhoB/C‐ROCK2 signaling. Modulating this axis ameliorates SCZ‐like phenotypes in mice and aligns with
Xiaojuan Gong, Lingxi Chen, Xin Guo, Anna Jiang, Yayi He, Chunxia Yan, Liang Ma, Jiayang Gao, Jinyu Zhang, Bao Zhang   +9 more
wiley   +1 more source

Sleep-Wake Disorders and a Look at Insomnia through Biological and Behavioral Perspectives [PDF]

, 2017
Insomnia is defined by difficulties in falling asleep, maintaining sleep, and problems with early morning awakenings. Unfortunately, due to these symptoms daytime fatigue often follows.
Fontanarosa, Mia
core   +1 more source

Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice

Advanced Science, EarlyView.
CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong, Duo Liu, Songsen Fu, Jiaming Zhang, Xi Chen, Songqiang Huang   +5 more
wiley   +1 more source

More anxious than depressed: prevalence and correlates in a 15-nation study of anxiety disorders in people with type 2 diabetes mellitus [PDF]

, 2019
Santosh K. Chaturvedi, Shayanth Manche Gowda, Helal Uddin Ahmed, Fahad D. Alosaimi, Nicola Andreone, А. Е. Бобров, Viola Bulgari, Giuseppe Carrà, Gianluca Castelnuovo, Giovanni de Girolamo, Tomasz Gondek, Nikola Jovanović, Thummala Kamala, Andrzej Kiejna, Nebojša Lalić, Dušica Lečić‐Toševski, Faiza Aslam, Victoria Mutiso, David M. Ndetei, Golam Rabbani, Suntibenchakul Somruk, S. Srikanta, Rizwan Taj, Umberto Valentini, Olivera Vuković, Wolfgang Wölwer, Larry Cimino, Arie Nouwen, Cathy E. Lloyd, Norman Sartorius   +29 more
openalex   +1 more source

Synaptic Dysfunction in the Anterior Cingulate Cortex Underlies Pain‐Anxiety Comorbidity in a Mandibular Asymmetry Mouse Model

Advanced Science, EarlyView.
This study establishes a mandibular asymmetry (MA) mouse model that recapitulates chronic orofacial pain and anxiety comorbidity. Anterior cingulate cortex (ACC) hyperactivation and synaptic dysfunction are identified as central neural mechanisms underlying these pathologies, with chemogenetic inhibition of ACC CaMKII+ neurons effectively reversing ...
Zhaoyichun Zhang, Yanran Zhang, Jialin Si, Honghui Mao, Feng He, Jin Ning, Guaiguai Ma, Xiaohua Chen, Haoxiang Xiao, Yuanyuan Zhu, Haifeng Zhang, Yifan Lu, Qian Liu, Meng Nian, Shiquan Sun, Shibin Yu, Shengxi Wu, Ze Fan, Zuolin Jin, Jing Huang   +19 more
wiley   +1 more source

Refractory Status Epilepticus and Therapeutic Uncertainties: a Comprehensive Review on Targeting Neuroinflammation and Rationale for Developing a Platform Trial

Advanced Science, EarlyView.
Refractory status epilepticus (RSE) is a life‐threatening neurological emergency with high rates of death and long‐term disability, but treatments for it are often based on limited evidence. RSE is now understood to involve neuroinflammation, which has led to the exploration of anti‐inflammatory and immunomodulatory agents like Tocilizumab. Traditional
Shanika Samarasekera, Suneesh Thilak, Asha Patel, Prashant Nasa, Zubair Ahmed, Lorraine Jacques, William J. Scotton, Cyril Chacko, Randeep Mullhi, Ruoling Chen, Vikram Patil, Suresh Renukappa, Tonny Veenith   +12 more
wiley   +1 more source

The Best Predictor of Anxiety, Stress, and Depression Among Institutionalized Elderly [PDF]

, 2019
Anxiety, stress, and depression are the three most common negative emotional constructs found in the elderly. Evidences available worldwide about how psychological problem could be resulted in mental disorder, and there is significant difference in the ...
Manungkalit, M. (Maria), Sari, N. P. (Ni)   +1 more
core  

Stress‐Induced Activation of Prolactin‐NR4A1‐Midkine Axis Exacerbates Skin Inflammation

Advanced Science, EarlyView.
Chronic psychological stress activates prolactin signaling to reprogram dermal fibroblasts into APCDD1+ inflammatory effectors via NR4A1, driving midkine secretion. This paracrine hub amplifies keratinocyte proliferation and immune recruitment, thus exacerbating skin inflammation.
Zhiguo Li, Huiyi Quan, Wanting Liu, Jiaoling Chen, Mengyang Chu, Xin Tang, Ke Xue, Xuan Liu, Jingyi Ma, Yaxing Bai, Ruina Dong, Bing Li, Junfeng Hao, Wei Guo, Qingyang Li, Erle Dang, Johann E Gudjonsson, Gang Wang, Shuai Shao   +18 more
wiley   +1 more source

Advanced Stem Cell Therapy: 3D‐Bioprinted Brain‐Like Transplants for Alzheimer's Disease‐Like Dementia

Advanced Science, EarlyView.
A tri‐component biomimetic bioink(gelatin/alginate/fibrinogen) is developed to protect cells in critical pathological environments in AD. Using this bioink, a 3D‐printed NPC construct optimized for hippocampal transplantation is provided to improve cell retention and differentiation in an AD‐like model. This approach enhances memory recovery and offers
Ke Gai, Yu Song, Dawen Gao, Qingning Nie, Xiao Luo, Caizhe Xu, Changhao Cai, Austin Smith, Xiang Li, Wei Shi, Lei Zhang, Wei Sun, Feng Lin   +12 more
wiley   +1 more source

Social Anxiety Disorder: A Short Commentary

, 2023
Anavi Sharma, Shivangi Sen
openalex   +2 more sources