Results 21 to 30 of about 977,682 (313)

Timing and Predictive Value of Clinical Conditions Preceding Multiple Sclerosis in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Multiple sclerosis (MS) patients often experience a higher incidence of clinical conditions before diagnosis, suggesting a prodromal phase. However, their predictive value and temporal trajectories remain underexplored. We investigated these aspects using the large UK Biobank's population‐based cohort, which provided clinical ...
Andrea Nova, Teresa Fazia, Giovanni Di Caprio, Davide Gentilini, Luisa Bernardinelli, Roberto Bergamaschi   +5 more
wiley   +1 more source

Efficacy of the Unified Protocol for transdiagnostic treatment of comorbid psychopathology accompanying emotional disorders compared to treatments targeting single disorders [PDF]

, 2018
OBJECTIVE: This study aimed to examine whether the Unified Protocol (UP), a transdiagnostic cognitive-behavioral therapy for emotional disorders (i.e., anxiety, mood, and related disorders), is efficacious in the treatment of co-occurring emotional ...
Ametaj, Amanda, Barlow, David H., Cassiello-Robbins, Clair, Farchione, Todd J., Sauer-Zavala, Shannon, Sbi, Sophia, Steele, Stephanie Jarvi   +6 more
core   +2 more sources

Central Dysmyelination in SSADH‐Deficient Humans and Mice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Succinic semialdehyde dehydrogenase deficiency (SSADHD) is an inherited metabolic disorder characterized by an accumulation of γ‐aminobutyric (GABA). In addition to its synaptic role as an inhibitory neurotransmitter, GABA also plays an important role in myelination.
Itay Tokatly Latzer, Henry H. C. Lee, Edward Yang, Cesar Alves, Mariarita Bertoldi, Caitlyn Fung, Spencer V. Steele, Eren Kule, Zijie Jin, Alexander Rotenberg, Jean‐Baptiste Roullet, Phillip L. Pearl   +11 more
wiley   +1 more source

Comorbid mood and anxiety disorders, suicidal behavior, and substance abuse among Black Caribbeans in the U.S.A. [PDF]

, 2012
The purpose of this study was to examine nativity and country of origin differences in comorbid mood (major depressive disorder, dysthymia, and bipolar I and II disorders) and anxiety (post-traumatic stress disorder, panic disorder, agora- phobia, social
Chatters, Linda M., Joe, Sean, Nguyen, Ann W., Sinkewicz, Marilyn, Taylor, Robert Joseph   +4 more
core   +1 more source

Medication Use in Multiple Sclerosis: A Population‐Based Comparison With the General Danish Population

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate the overall use of prescription medications among individuals with multiple sclerosis compared to the general population, with a focus on treatments beyond disease‐modifying therapies. Methods We conducted a nationwide, registry‐based study in Denmark.
Josefine Windfeld‐Mathiasen, Henrik Horwitz, Ida M. Heerfordt, Elisabeth Framke, Melinda Magyari   +4 more
wiley   +1 more source

Separaxion anxiety in pediatric migraine without aura: A pilot study [PDF]

, 2017
Background: Separation anxiety (SA) can be defined as the fear reaction and protest manifested by children when the main caregivers move away from him/her or in front of unfamiliar person. SA near eight months may be considered as an important and normal
Di Filippo T., Di Folco A., Gabriele Tripi, Maltese A., Parisi L., Romano P., Salerno M.   +6 more
core   +1 more source

Genetics of Anxiety Disorders

Current Psychiatry Reports, 2019
Anxiety disorders are among the most common mental disorders with a lifetime prevalence of over 20%. Clinically, anxiety is not thought of as a homogenous disorder, but is subclassified in generalized, panic, and phobic anxiety disorder. Anxiety disorders are moderately heritable.
Jürgen Deckert, Sandra Meier, Sandra Meier, Sandra Meier   +3 more
openaire   +4 more sources

Efgartigimod Combined With Steroid Treatment for HAM/TSP: A Case Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT HTLV‐1‐associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a progressive neurological disorder with limited treatment options. We report a 54‐year‐old female with decade‐long, progressive HAM/TSP, previously refractory to rituximab, who experienced worsening spastic paraparesis and neurogenic bladder dysfunction.
Jiahui Zeng, Wotu Tian, Jingran Yang, Yanping Yang, Li Cao, Xinghua Luan   +5 more
wiley   +1 more source

Anxiety Disorders are Associated with Reduced Heart Rate Variability: A Meta-Analysis [PDF]

, 2014
Background: Anxiety disorders increase risk of future cardiovascular disease (CVD) and mortality, even after controlling for confounds including smoking, lifestyle, and socioeconomic status, and irrespective of a history of medical disorders.
Agelink, Agorastos, Alvarenga, Alvares, Asmundson, Baker, Ballenger, Bar-Haim, Barlow, Begg, Benkelfat, Berntson, Berntson, Billman, Billman, Blechert, Borenstein, Bornas, Bornas, Brosschot, Brosschot, Busscher, Chang, Cohen, Cohen, Cohen, Cohen, Danesh, Dekker, Diveky, Duncan, Duval, Egger, Einvik, Fei, Friedman, Gaebler, Gao, Garakani, Hammel, Hauschildt, Heathers, Hedges, Higgins, Hoehn-Saric, Huston, Härter, Ito, Janszky, Kang, Keary, Kemp, Kemp, Kemp, Kessler, Kessler, Kessler, Kikuchi, Klein, Kollai, Kubzansky, La Rovere, Lakusic, Lavoie, Licht, Lyonfields, Malik, Martens, Martinez, Mathewson, McCarthy, McCraty, McEntee, Melzig, Michaloudis, Middleton, Miller, Moher, Mrosovsky, Norte, Pavlov, Petrowski, Petruzzello, Phillips, Pittig, Porges, Prasko, Quintana, Rennie, Reyes del Paso, Roest, Sack, Shadish, Shah, Shaikh al arab, Shibeshi, Slaap, Thayer, Thayer, Thayer, Thayer, Thayer, Tracey, Tsuji, Tucker, Tucker, Tully, Vogel, Vogelzangs, Wahbeh, Wang, Wise, Yeragani, Yeragani, Yeragani, Zahn   +115 more
core   +2 more sources

Practice Recommendations for Genetic Testing of Ataxias

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Over the past decade, significant advances in genetic testing for ataxia have improved diagnostic accuracy, informed clinical trial eligibility, guided treatment decisions, and enabled cascade testing of at‐risk relatives. While guidance exists for other neurogenetic conditions, there are no standardized guidelines on genetic ...
Sharan R. Srinivasan, Amy D. Mook, Michelle Rochman, Jin Yun Helen Chen, Weiyi Mu, George R. Wilmot, Liana S. Rosenthal, Wendy R. Uhlmann   +7 more
wiley   +1 more source