Results 41 to 50 of about 1,037,362 (313)

Emotion regulation difficulties related to depression and anxiety : a network approach to model relations among symptoms, positive reappraisal, and repetitive negative thinking [PDF]

, 2019
Frequent repetitive negative thinking and infrequent positive reappraisal use are theorized to increase risk for depression and anxiety. Yet, research has studied these regulatory strategies at the disorder level, ignoring the clinical heterogeneity and ...
Everaert, Jonas, Joormann, Jutta
core   +2 more sources

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Protocol for a randomized controlled trial examining multilevel prediction of response to behavioral activation and exposure-based therapy for generalized anxiety disorder. [PDF]

, 2020
BACKGROUND:Only 40-60% of patients with generalized anxiety disorder experience long-lasting improvement with gold standard psychosocial interventions. Identifying neurobehavioral factors that predict treatment success might provide specific targets for ...
Abelson, J, Akeman, E, Aupperle, Robin L, Bodurka, J, Clausen, AN, Cosgrove, KT, Craske, MG, Kirlic, N, Martell, C, Mathis, B, McDermott, TJ, Paulus, M, Santiago, J, Thompson, WK, Wolitzky-Taylor, K   +14 more
core   +1 more source

Practice Recommendations for Genetic Testing of Ataxias

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Over the past decade, significant advances in genetic testing for ataxia have improved diagnostic accuracy, informed clinical trial eligibility, guided treatment decisions, and enabled cascade testing of at‐risk relatives. While guidance exists for other neurogenetic conditions, there are no standardized guidelines on genetic ...
Sharan R. Srinivasan, Amy D. Mook, Michelle Rochman, Jin Yun Helen Chen, Weiyi Mu, George R. Wilmot, Liana S. Rosenthal, Wendy R. Uhlmann   +7 more
wiley   +1 more source

The Overall Anxiety Severity and Impairment Scale as an Outcome Measure in Internet-Delivered Cognitive Behavioral Therapy for Anxiety Disorders: Observational Study

Journal of Medical Internet Research, 2023
BackgroundInternet-delivered cognitive behavioral therapy (iCBT) is effective in the treatment of anxiety disorders. iCBT clinical trials use relatively long and time-consuming disorder-specific rather than transdiagnostic anxiety
Boris Karpov, Jari Olavi Lipsanen, Ville Ritola, Tom Rosenström, Suoma Saarni, Satu Pihlaja, Jan-Henry Stenberg, Paula Laizane, Grigori Joffe   +8 more
doaj   +1 more source

Chronic Pain in Parkinson’s Disease: Prevalence, Sex Differences, Regional Anatomy and Comorbidities

Annals of Clinical and Translational Neurology, EarlyView.
Chronic pain affected 66.2% of 10,631 individuals with Parkinson's disease, with higher prevalence and severity in females. Pain most often involved the buttocks, lower back, neck, and knees, and was linked to depression, sleep disorders, and osteoarthritis.
Natalia S. Ogonowski, Freddy Chafota, Fangyuan Cao, Amanda Wei Yin Lim, Victor Flores‐Ocampo, Santiago Díaz‐Torres, Zuriel Ceja, Luis M. García‐Marín, Scott F. Farrell, Kishore R. Kumar, Jane Alty, George D. Mellick, Trung Thành Ngô, Miguel E. Rentería   +13 more
wiley   +1 more source

Rosacea associated with increased risk of generalized anxiety disorder: a case-control study of prevalence and risk of anxiety in patients with rosacea, [PDF]

Anais Brasileiros de Dermatologia, 2020
Background: Rosacea may result in emotional distress and anxiety. However, data on the presence of generalized anxiety disorder in rosacea patients are scarce.
Pinar Incel Uysal, Neslihan Akdogan, Yildiz Hayran, Ayse Oktem, Basak Yalcin   +4 more
doaj   +1 more source

Anxiety Disorders are Associated with Reduced Heart Rate Variability: A Meta-Analysis [PDF]

, 2014
Background: Anxiety disorders increase risk of future cardiovascular disease (CVD) and mortality, even after controlling for confounds including smoking, lifestyle, and socioeconomic status, and irrespective of a history of medical disorders.
Agelink, Agorastos, Alvarenga, Alvares, Asmundson, Baker, Ballenger, Bar-Haim, Barlow, Begg, Benkelfat, Berntson, Berntson, Billman, Billman, Blechert, Borenstein, Bornas, Bornas, Brosschot, Brosschot, Busscher, Chang, Cohen, Cohen, Cohen, Cohen, Danesh, Dekker, Diveky, Duncan, Duval, Egger, Einvik, Fei, Friedman, Gaebler, Gao, Garakani, Hammel, Hauschildt, Heathers, Hedges, Higgins, Hoehn-Saric, Huston, Härter, Ito, Janszky, Kang, Keary, Kemp, Kemp, Kemp, Kessler, Kessler, Kessler, Kikuchi, Klein, Kollai, Kubzansky, La Rovere, Lakusic, Lavoie, Licht, Lyonfields, Malik, Martens, Martinez, Mathewson, McCarthy, McCraty, McEntee, Melzig, Michaloudis, Middleton, Miller, Moher, Mrosovsky, Norte, Pavlov, Petrowski, Petruzzello, Phillips, Pittig, Porges, Prasko, Quintana, Rennie, Reyes del Paso, Roest, Sack, Shadish, Shah, Shaikh al arab, Shibeshi, Slaap, Thayer, Thayer, Thayer, Thayer, Thayer, Tracey, Tsuji, Tucker, Tucker, Tully, Vogel, Vogelzangs, Wahbeh, Wang, Wise, Yeragani, Yeragani, Yeragani, Zahn   +115 more
core   +2 more sources

Genetic Modifiers of Parkinson's Disease: A Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the associations of LRRK2 p.G2019S, GBA1 p.N409S, polygenic risk scores (PRS), and APOE E4 on PD penetrance, risk, and symptoms. Methods We conducted a US‐based observational case–control study using data from the 23andMe Inc. and Fox Insight Genetic Substudy (FIGS) databases.
Matthew J. Kmiecik, Michael V. Holmes, Pierre Fontanillas, Giulietta M. Riboldi, Ruth B. Schneider, Jingchunzi Shi, Anna Guan, Susana Tat, Steven Micheletti, Keaton Stagaman, Josh Gottesman, David A. Hinds, Joyce Y. Tung, 23andMe Research Team, Stella Aslibekyan, Lucy Norcliffe‐Kaufmann   +15 more
wiley   +1 more source

Increased risk of suicide among patients with social anxiety disorder

Epidemiology and Psychiatric Sciences
Aims Increasing evidence has established a strong association between social anxiety disorder and suicidal behaviours, including suicidal ideation and suicide attempts.
Han-Ting Wei, Shih-Jen Tsai, Chih-Ming Cheng, Wen-Han Chang, Ya-Mei Bai, Tung-Ping Su, Tzeng-Ji Chen, Mu-Hong Chen   +7 more
doaj   +1 more source