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Expert Opinion on Emerging Drugs, 2007
Anxiety disorders are the most common of the psychiatric disorders and are also associated with significant economic costs and impaired work productivity. The first-line pharmacotherapy of pharmatherapy for a number of anxiety disorders comprises selective serotonin re-uptake inhibitors (SSRIs) and serotonin and noradrenaline re-uptake inhibitors ...
Nirvana S, Pillay, Dan J, Stein
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Anxiety disorders are the most common of the psychiatric disorders and are also associated with significant economic costs and impaired work productivity. The first-line pharmacotherapy of pharmatherapy for a number of anxiety disorders comprises selective serotonin re-uptake inhibitors (SSRIs) and serotonin and noradrenaline re-uptake inhibitors ...
Nirvana S, Pillay, Dan J, Stein
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Progress in Neuro-Psychopharmacology and Biological Psychiatry, 1985
Sixty (60) out-patients with DSM III generalized anxiety disorder were treated after a 1-week placebo washout in a 4-week double-blind study with buspirone, diazepam and placebo; after which they were withdrawn abruptly from medication or assigned to a 2-week period of placebo.
J C, Pecknold +5 more
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Sixty (60) out-patients with DSM III generalized anxiety disorder were treated after a 1-week placebo washout in a 4-week double-blind study with buspirone, diazepam and placebo; after which they were withdrawn abruptly from medication or assigned to a 2-week period of placebo.
J C, Pecknold +5 more
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Behavioural Pharmacology, 1998
A recent report suggested that barakol, a biologically active extract of the south-east Asian plant, Cassia siamea, has anxiolytic properties. The purpose of the present study was to replicate and extend these findings by examining the dose-response effects of barakol (0-20 mg/kg) in two pharmacologically validated tests of rat anxiety: the elevated ...
D. F. Fiorino +4 more
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A recent report suggested that barakol, a biologically active extract of the south-east Asian plant, Cassia siamea, has anxiolytic properties. The purpose of the present study was to replicate and extend these findings by examining the dose-response effects of barakol (0-20 mg/kg) in two pharmacologically validated tests of rat anxiety: the elevated ...
D. F. Fiorino +4 more
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Expert Opinion on Investigational Drugs, 2003
Pregabalin (S-[+]-3-isobutylgaba) was designed as a lipophilic GABA (gamma-aminobutyric acid) analogue substituted at the 3'-position in order to facilitate diffusion across the blood-brain barrier. It was originally developed as an anticonvulsant agent, however it has been shown to be effective in the treatment of several disorders including ...
Robert Pohl, Bianca Lauria-Horner
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Pregabalin (S-[+]-3-isobutylgaba) was designed as a lipophilic GABA (gamma-aminobutyric acid) analogue substituted at the 3'-position in order to facilitate diffusion across the blood-brain barrier. It was originally developed as an anticonvulsant agent, however it has been shown to be effective in the treatment of several disorders including ...
Robert Pohl, Bianca Lauria-Horner
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Hypnosedatives and Anxiolytics
2008Hypnosedatives and Anxiolytics are commonly prescribed drugs. This chapter presents an overview of adverse effects of hypnosedatives and anxiolytics published in recent years. This chapter covers some benzodiazepines (Alprazolam, Clobazam, Clonazepam, Clonazepam, Diazepam, Midazolam, and Lorazepam), benzodiazepine-like drugs (Eszopiclone, Zaleplon ...
Stephen Curran +2 more
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Anxiolytic-Like Effect of Baicalin and its Additivity with other Anxiolytics [PDF]
Planta Medica, 2006 Baicalin, a naturally occurring flavonoid, was previously reported to exert anxiolytic-like effects in the Vogel conflict test. In the present study, the anxiolytic effects of baicalin alone and in combination with other anxiolytics were tested in mice using the elevated plus-maze (EPM).
Xu, Zhiwen +7 more
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Pharmacogenetics of anxiolytic drugs
Journal of Neural Transmission, 2009Acute and chronic anxiety represents the core symptoms in anxiety disorders. Anxiolytic pharmacological treatment mainly consists in administration of benzodiazepines and antidepressants. Whereas benzodiazepines show little, antidepressants show a relative large interindividual variability in terms of drug response where about one-third of patients do ...
Renan P. Souza +3 more
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Pharmacology Biochemistry and Behavior
Anxiety disorders are the most prevalent psychiatric pathology with substantial cost to society, but the existing treatments are often inadequate. This has rekindled the interest in the GABAA-receptor (GABAAR) positive allosteric modulator (PAM) compounds, which have a long history in treatment of anxiety beginning with diazepam, chlordiazepoxide, and ...
Rok, Cerne +3 more
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Anxiety disorders are the most prevalent psychiatric pathology with substantial cost to society, but the existing treatments are often inadequate. This has rekindled the interest in the GABAA-receptor (GABAAR) positive allosteric modulator (PAM) compounds, which have a long history in treatment of anxiety beginning with diazepam, chlordiazepoxide, and ...
Rok, Cerne +3 more
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Mental Retardation and Developmental Disabilities Research Reviews, 1999
The nature of anxiety and its biological basis is reviewed, as are the causes and types of pathological anxiety and their pharmacological treatment. The main drugs used in the treatment of anxiety work by depressing the brain and hence perception and response to stressors.
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The nature of anxiety and its biological basis is reviewed, as are the causes and types of pathological anxiety and their pharmacological treatment. The main drugs used in the treatment of anxiety work by depressing the brain and hence perception and response to stressors.
openaire +2 more sources