Results 111 to 120 of about 3,137 (211)
Artificial Organs, EarlyView.HeartWare‐BiVAD was associated with more frequent right ventricular cannulation, whereas HM3‐BiVAD demonstrated a trend toward improved survival despite a more severe preimplant clinical profile, suggesting a potential device‐related advantage of HM3 in biventricular support.
Daler Rahimov +10 more
wiley +1 more source
Artificial Organs, EarlyView.Our study validates non‐invasive stroke work estimation algorithms derived from LVAD pump parameters across preload reduction (inferior vena cava occlusion), afterload increase (aorta descendens occlusion), contractility increase (dobutamine infusion), and LVAD speed ramp interventions in 22 pigs.
Moriz A. Habigt +7 more
wiley +1 more source
Artificial Organs, EarlyView.An experimental framework using a 3D‐printed method has been evaluated to be used for systematic hemocompatibility studies of key impeller parameters in rotodynamic blood pumps. Standard deviation comparisons of haemolysis and pressure indicators between a control and two 3D‐printed pumps have shown the good reproducibility of the framework.
Aldo J. Suria +4 more
wiley +1 more source
Australian Veterinary Journal, EarlyView.Background Mediastinal lymphoma in feline leukaemia virus (FeLV)‐positive cats is associated with a poor prognosis, and therapeutic options may be limited when adequate disease control is not achieved with chemotherapy. The efficacy of radiation therapy in this setting has not been established.
A Uno, T Hasegawa, T Mori
wiley +1 more source
Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders
British Journal of Pharmacology, EarlyView.Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman +3 more
wiley +1 more source
Cardiovascular toxicity from immune checkpoint inhibitor therapy: an inflammatory continuum
British Journal of Pharmacology, EarlyView.Immune checkpoint inhibitor (ICI) therapy has markedly improved outcomes in advanced malignancies but has also revealed a distinct spectrum of cardiovascular immune‐related adverse events. Myocarditis represents the most severe manifestation, while non‐inflammatory left ventricular dysfunction and vascular inflammation have emerged as additional ...
Fabrice Reyes +7 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose Atherosclerosis, a chronic inflammatory disease characterised by lipid accumulation and endothelial dysfunction, remains a leading cause of cardiovascular morbidity and mortality. While cannabinoid 2 (CB2) receptor agonists show therapeutic promise in preclinical studies, their systemic application is hindered by poor ...
Lucía Martín‐Navarro +3 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Kininase I, comprising carboxypeptidase N (CPN) and carboxypeptidase M, regulates kinin activity and is up‐regulated during injury, inflammation and immune activation. Under these conditions, kininase I converts bradykinin and kallidin into des‐Arg kinins, primary endogenous agonists of the bradykinin B1 receptor (R ...
Acacia White +5 more
wiley +1 more source
Cell Proliferation, EarlyView.MD‐1 is induced and activated in macrophages. The activated MD‐1 subsequently promotes the cGAS‐STING‐TBK1‐IRF3 signalling pathway to activate the NLRP3 inflammasome, and subsequently increases pro‐inflammatory macrophage polarisation and decreases plaque stability to accelerate the development of atherosclerosis.
Fang Zhao +9 more
wiley +1 more source