Results 31 to 40 of about 98,167 (262)

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

Engineering Morphological Anisotropy to Control the In Vivo Transport Dynamics, Clearance, and Biodistribution of Silica Nanocarriers

Advanced Science, EarlyView.
Morphological anisotropy directs the in vivo transport under physiological flow and clearance of silica nanocarriers. Increasing anisotropy reduces cellular uptake, suppresses hepatic and splenic sequestration, and prolongs systemic circulation by steering particles toward the central flow core.
Xiaofei Li, Yingjie Yu, Tianchang He, Xiaoyan Fang, Wenhua Yang, Luying Zhou, Hao Fan, Guimei Lin, Daniel Crespy, Katharina Landfester, Junfeng Zhang, Shuai Jiang   +11 more
wiley   +1 more source

Aneurismas en la aorta abdominal: presentación de un caso Aneurisms in the abdominal aorta: presentation of a case

Revista Médica Electrónica, 2012
El aneurisma de la aorta abdominal ha sido reconocido como un importante problema de salud en la última década. Las anomalías del árbol vascular son comunes. Los aneurismas aislados de la arteria aorta son de observación bastante frecuentes.
Yariana Martínez Sánchez, José Antonio Rodríguez González, Nereida Estorino Escaig, María Cristina Martí Coruña   +3 more
doaj  

Aneurisma de aorta abdominal roto: ¿Qué estamos haciendo?

Repertorio de Medicina y Cirugía, 2009
Estudio descriptivo retrospectivo realizado en el servicio de cirugía vascular periférica del Hospital de San José de Bogotá D.C. Colombia, en un período de seis años.
José Enqrique Montoya R., José L. Mercado, Oswaldo Ceballos B.   +2 more
doaj   +1 more source

Endofuga tipo IB, complicación tardia de prótesis endovascula

Repertorio de Medicina y Cirugía, 2020
Objetivo: describir las endofugas como complicación tardía de las prótesis por reparación endovascular de aneurisma de aorta abdominal, a través del reporte de caso presentado en el Hospital Universitario del Quindío San Juan de Dios Colombia. Diseño del
Maria del Pilar Cristancho, Diana Paola Cardona Castellanos, German A. Téllez Ramírez   +2 more
doaj   +1 more source

Treatment of coral reef aorta with descending thoracic aorta bypass: A case report and literature review

Annals of Vascular Surgery - Brief Reports and Innovations, 2023
Descending thoracic aorta (DTA) inflow has been utilized as a secondary choice for restoring blood flow in cases of aortoiliac occlusive disease. This option is considered when graft failure, infection, or other intra-abdominal conditions contraindicates
Celso Nunes, Ricardo V. Pereira, João O'neill Pedrosa, Vânia Oliveira, Eduardo Silva, Leonor Baldaia, Miguel Silva, Gabriel Anacleto   +7 more
doaj   +1 more source

Plaque‐Hepatic Targeting Nanotherapy Disrupts the PCSK9‐LOX‐1 Axis to Suppress oxLDL in Atherosclerosis

Advanced Science, EarlyView.
Self‑amplifying PCSK9–LOX‑1 feedback axis drives atherosclerotic progression by promoting oxLDL generation and endothelial uptake. A dual‑targeting nanoplatform (siPCSK9@PEAL NPs‑aL) is constructed to simultaneously silence hepatic PCSK9 for lipid lowering and block plaque LOX‑1 for anti‑inflammation.
Yi Duan, Yijie Qiu, Yan Zhu, Quan Wang, Jiangtao Lin, Yourong Duan, Qi Wang, Yi Dong   +7 more
wiley   +1 more source

Descrição morfológica dos ramos colaterais viscerais da aorta abdominal do macaco-de-cheiro Morphological description of the collateral visceral branches from abdominal aorta of squirrel monkey

Ciência Rural, 2011
O Saimiri sciureus é um primata não humano existente na região amazônica e não consta na lista de animais em perigo de extinção, de acordo com o IBAMA. Neste trabalho, sistematizou-se os ramos colaterais viscerais da aorta abdominal de seis animais sendo
Maria Rogéria Menezes da Silva, Ana Rita Lima, Antônio Carlos Cunha Lacreta Junior, Mirian Naomi Ishizaki, Aline Amaral Imbeloni, José Augusto Pereira Carneiro Muniz, Érika Renata Branco   +6 more
doaj   +1 more source

Radical Resection of the Third Portion of the Duodenum for Secondary Aortoduodenal Fistula

Annals of Gastroenterological Surgery, EarlyView.
Secondary aortoduodenal fistula most commonly involves the third portion of the duodenum and requires definitive management of both vascular and gastrointestinal components. We demonstrate a step‐by‐step technique for radical duodenal resection and reconstruction performed in structured collaboration with cardiovascular surgeons.
Koji Kubota, Akira Shimizu, Tsuyoshi Notake, Tatsuichiro Seto, Yuji Soejima   +4 more
wiley   +1 more source