Results 41 to 50 of about 607,556 (305)

Successful percutaneous retrieval of a micra transcatheter pacing system at 8 weeks after implantation

Journal of Arrhythmia, 2018
An 86‐year‐old woman suffering from repeated methicillin‐resistant Staphylococcus aureus (MRSA) bacteremia underwent percutaneous lead extraction using an excimer laser. Since negative blood cultures were confirmed three times after lead extraction under
Masatsugu Nozoe, Daisuke Yoshida, Daisuke Nagatomo, Nobuhiro Suematsu, Toru Kubota, Masanori Okabe, Yusuke Yamamoto   +6 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Hypertension, aortic stenosis, and aortic regurgitation [PDF]

Annals of Translational Medicine, 2018
The prevalence of hypertension (1) and of valvular aortic stenosis (2) increase with age, and both hypertension (3,4) and valvular aortic stenosis (5) cause left ventricular hypertrophy. Both hypertension (1,3) and valvular aortic stenosis (2,6) are also associated with an increased incidence of cardiovascular events and mortality. Hypertension (either
openaire   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Diagnostic accuracy of mediastinal width measurement on posteroanterior and anteroposterior chest radiographs in the depiction of acute nontraumatic thoracic aortic dissection [PDF]

, 2012
We aimed to explore the diagnostic accuracy of various mediastinal measurements in determining acute nontraumatic thoracic aortic dissection with respect to posteroanterior (PA) and anteroposterior (AP) chest radiographs, which had received little ...
Wan Chi Chan, Yeung, Tsz Wai, Chan, Wan Chi, Lai, Vincent, Tsz Wai Yeung, Vincent Lai, Wai Kan Tsang, Tsang, Wai Kan   +7 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

High-sensitivity troponin I concentrations are a marker of an advanced hypertrophic response and adverse outcomes in patients with aortic stenosis [PDF]

, 2014
AIMS: High-sensitivity cardiac troponin I (cTnI) assays hold promise in detecting the transition from hypertrophy to heart failure in aortic stenosis.
Lang, Chim C., Langrish, Jeremy P, Langrish, Jeremy P., Newby, David E., Shah, Anoop, Dweck, Marc R, Alam, Shirjel, Mills, Nicholas L; id_orcid, McAllister, David A, Hunter, Amanda L., Cowell, S. Joanna, Boon, Nicholas A, Shah, Anoop S.V., Strachan, Fiona E, McAllister, David A., Maria Choy, Anna; id_orcid, Strachan, Fiona E., Boon, Nicholas A., Mills, Nicholas L., Dweck, Marc R., Shah, Anoop S. V., Newby, David E, Lang, Chim C.; id_orcid, Chin, Calvin W.L., Chin, Calvin W L, Chin, Calvin W. L., Joanna Cowell, S, Maria Choy, Anna, Walker, Simon, Lang, Chim C, Hunter, Amanda L   +30 more
core   +1 more source

Living in disadvantaged neighborhoods linked to less intervention for severe aortic stenosis

Scientific Reports
To investigate the association between area deprivation index (ADI) and aortic valve replacement (AVR) in patients with severe aortic stenosis (AS). Patients aged 40–95 years with severe AS confirmed by echocardiography were included.
Chirag Ram, Sameh Yousef, Wei-Guo Ma, Ishani Vallabhajosyula, Saket Singh, Ritu Agarwal, Rita K. Milewski, Roland Assi, Prakash A. Patel, Matthew Williams, Arnar Geirsson, Prashanth Vallabhajosyula   +11 more
doaj   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source