Results 1 to 10 of about 723,404 (367)

Mechanisms of oxidative stress in human aortic aneurysms — association with clinical risk factors for atherosclerosis and disease severity [PDF]

, 2013
Aortic abdominal aneurysms (AAA) are important causes of cardiovascular morbidity and mortality. Oxidative stress may link multiple mechanisms of AAA including vascular inflammation and increased metalloproteinase activity.
Bujak-Gizycka, Beata, Chwała, Maciej, Filip, Grzegorz, Grudzien, Grzegorz, Guzik, Bartłomiej, Guzik, Tomasz J., Kapelak, Boguslaw, Korbut, Ryszard, Ludew, Dominik, Mrowiecki, Tomasz, Mrowiecki, Wojciech, Sadowski, Jerzy, Sagan, Agnieszka, Żmudka, Krzysztof   +13 more
core   +2 more sources

H19 Induces Abdominal Aortic Aneurysm Development and Progression

Circulation, 2018
Background: Long noncoding RNAs have emerged as critical molecular regulators in various biological processes and diseases. Here we sought to identify and functionally characterize long noncoding RNAs as potential mediators in abdominal aortic aneurysm ...
Daniel Y. Li, A. Busch, Hong Jin, E. Chernogubova, J. Pelisek, J. Karlsson, B. Sennblad, Shengliang Liu, Shen Lao, P. Hofmann, A. Bäcklund, Suzanne M. Eken, J. Roy, P. Eriksson, Brian Dacken, D. Ramanujam, A. Dueck, S. Engelhardt, R. Boon, H. Eckstein, J. Spin, P. Tsao, L. Maegdefessel   +22 more
semanticscholar   +1 more source

TGFβ (transforming growth factor-β) blockade induces a human-like disease in a nondissecting mouse model of abdominal aortic aneurysm [PDF]

, 2017
Objective-Current experimental models of abdominal aortic aneurysm (AAA) do not accurately reproduce the major features of human AAA. We hypothesized that blockade of TGF beta (transforming growth factor-beta) activity-a guardian of vascular integrity ...
Clément, Marc, Esposito, Bruno, Finigan, Alison, Lareyre, Fabien, Mallat, Ziad, Master, Leanne, Patel, Meghana, Pohlod, Stefanie, Raffort, Juliette, Stergiopulos, Nikolaos, Taleb, Soraya, Trachet, Bram, Vandestienne, Marie   +12 more
core   +2 more sources

ROBO4 Variants Predispose Individuals to Bicuspid Aortic Valve and Thoracic Aortic Aneurysm

Nature Genetics, 2018
Bicuspid aortic valve (BAV) is a common congenital heart defect (population incidence, 1–2%)1–3 that frequently presents with ascending aortic aneurysm (AscAA)4.
Russell A. Gould, Hamza Aziz, Courtney E. Woods, Manuel A. Seman-Senderos, E. Sparks, Christoph Preuss, Florian Wünnemann, D. Bedja, Cassandra R. Moats, S. McClymont, Rebecca J. Rose, N. Sobreira, H. Ling, G. MacCarrick, A. A. Kumar, I. Luyckx, E. Cannaerts, A. Verstraeten, Hanna M. Björk, Ann-Cathrin Lehsau, Vinod Jaskula-Ranga, H. Lauridsen, A. Shah, Christopher L. Bennett, P. Ellinor, Honghuang Lin, E. Isselbacher, C. L. Lino Cardenas, J. Butcher, G. Hughes, M. Lindsay, David Hua James Valle Ling Lupski, D. Valle, J. Lupski, Harry C. Andrew S. Gregor Bart L. Lut Per Salah A. Luc A Dietz McCallion Andelfinger Loeys Van Laer Eriksso, Harry C. Dietz, A. McCallion, Gregor Andelfinger, B. Loeys, L. Van Laer, P. Eriksson, S. A. Mohamed, L. Mertens, A. Franco-Cereceda, S. Mital, J. Verhagen, M. Wessels, S. Mital, Gregor Andelfinger, A. McCallion, Harry C. Dietz   +50 more
semanticscholar   +1 more source

Applying modified external aortic root support for treatment of ascending thoracic aorta aneurism and type II aortic dissection in an elderly patient: A case report study

Annals of Vascular Surgery - Brief Reports and Innovations, 2023
The ascending thoracic aortic aneurysm, when combined with aortic dissection, led to a critical medical condition requiring emergent and suitable action.
Mohammadhosein Akhlaghpasand, Setayesh Farahani, Sam-Zeraatian Nejad, Ida Mohammadi, Foolad Eghbali   +4 more
doaj  

Association of Aortic Aneurysms and Dissections With Subarachnoid Hemorrhage

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background It is uncertain whether aortic diseases, such as aneurysm and dissection, are associated with intracranial aneurysm formation and aneurysmal subarachnoid hemorrhage (SAH). Methods and Results We used data on claims between 2008 and 2015 from a
Mais Al‐Kawaz, Hooman Kamel, Santosh B. Murthy, Alexander E. Merkler   +3 more
doaj   +1 more source

Evolution of the wall shear stresses during the progressive enlargement of symmetric abdominal aortic aneurysms. [PDF]

, 2006
The changes in the evolution of the spatial and temporal distribution of the wall shear stresses (WSS) and gradients of wall shear stresses (GWSS) at different stages of the enlargement of an abdominal aortic aneurysm (AAA) are important in understanding
Chomaz, JM, Lasheras, JC, Salsac, A-V, Sparks, SR   +3 more
core   +3 more sources

Diabetes and aortic aneurysm: current state of the art

Cardiovascular Research, 2018
Aortic aneurysm is a life-threatening disease due to the risk of aortic rupture. The only curative treatment available relies on surgical approaches; drug-based therapies are lacking, highlighting an unmet need for clinical practice.
J. Raffort, F. Lareyre, M. Clément, R. Hassen-Khodja, G. Chinetti, Z. Mallat   +5 more
semanticscholar   +1 more source

Vascular airway compression management in a case of aortic arch and descending thoracic aortic aneurysm

Annals of Cardiac Anaesthesia, 2016
Airway compression due to distal aortic arch and descending aortic aneurysm repair has been documented. This case of tracheal and left main stem bronchus compression due to aortic aneurysm occurred in a 42-year-old man.
Alok Kumar, Vikas Dutta, Sunder Negi, G D Puri   +3 more
doaj   +1 more source

Comparative analysis of thoracic and abdominal aortic aneurysms across the segment and species at the single-cell level

Frontiers in Pharmacology, 2023
Introduction: Aortic aneurysm is a life-threatening disease resulted from progressive dilatation of the aorta, which can be subdivided into thoracic and abdominal aortic aneurysms.
Hong Wu, Cheng Xie, Ruilin Wang, Jun Cheng, Qingbo Xu, Haige Zhao   +5 more
doaj   +1 more source