Results 11 to 20 of about 747,172 (250)

Through network pharmacology and molecular docking to explore the underlying mechanism of Artemisia annua L. treating in abdominal aortic aneurysm

Frontiers in Physiology, 2022
Background: Abdominal aortic aneurysm (AAA) is a degenerative disease that causes health problems in humans. However, there are no effective drugs for the treatment of AAA. Artemisia annua L. (A.
Longyuan Jia, Longyuan Jia, Yuchen Jing, Yuchen Jing, Ding Wang, Ding Wang, Shuai Cheng, Shuai Cheng, Chen Fu, Xiangyu Chu, Xiangyu Chu, Chenye Yang, Chenye Yang, Bo Jiang, Bo Jiang, Shijie Xin, Shijie Xin   +16 more
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Single-cell RNA sequencing reveals the vascular smooth muscle cell phenotypic landscape in aortic aneurysm

Cell Communication and Signaling, 2023
Background and objectives Phenotypic switching in vascular smooth muscle cells (VSMCs) has been linked to aortic aneurysm, but the phenotypic landscape in aortic aneurysm is poorly understood.
Genmao Cao, Xuezhe Xuan, Yaling Li, Jie Hu, Ruijing Zhang, Haijiang Jin, Honglin Dong   +6 more
semanticscholar   +1 more source

Applying multi-omics techniques to the discovery of biomarkers for acute aortic dissection

Frontiers in Cardiovascular Medicine, 2022
Acute aortic dissection (AAD) is a cardiovascular disease that manifests suddenly and fatally. Due to the lack of specific early symptoms, many patients with AAD are often overlooked or misdiagnosed, which is undoubtedly catastrophic for patients.
Xinyu Hao, Xinyu Hao, Shuai Cheng, Shuai Cheng, Bo Jiang, Bo Jiang, Shijie Xin, Shijie Xin   +7 more
doaj   +1 more source

Immune and inflammatory mechanisms of abdominal aortic aneurysm

Frontiers in Immunology, 2022
Abdominal aortic aneurysm (AAA) is a life-threatening cardiovascular disease. Immune-mediated infiltration and a destruction of the aortic wall during AAA development plays significant role in the pathogenesis of this disease.
A. C. Márquez-Sánchez, E. Koltsova
semanticscholar   +1 more source

Burden of Aortic Aneurysm and Its Attributable Risk Factors from 1990 to 2019: An Analysis of the Global Burden of Disease Study 2019

Frontiers in Cardiovascular Medicine, 2022
Background Global and national estimates on the epidemiology of aortic aneurysms are prerequisites for disease management and policymaking. Based on the Global Burden of Disease (GBD) 2019, this study aimed to discern the global aortic aneurysm burden by
Zhuo Wang, Yayu You, Z. Yin, Qinyi Bao, Shuxin Lei, Jiaye Yu, Cuiping Xie, Feiming Ye, Xiaojie Xie   +8 more
semanticscholar   +1 more source

Identification of key monocytes/macrophages related gene set of the early-stage abdominal aortic aneurysm by integrated bioinformatics analysis and experimental validation

Frontiers in Cardiovascular Medicine, 2022
ObjectiveAbdominal aortic aneurysm (AAA) is a lethal peripheral vascular disease. Inflammatory immune cell infiltration is a central part of the pathogenesis of AAA.
Shuai Cheng, Shuai Cheng, Shuai Cheng, Yuanlin Liu, Yuanlin Liu, Yuanlin Liu, Yuchen Jing, Yuchen Jing, Yuchen Jing, Bo Jiang, Bo Jiang, Bo Jiang, Ding Wang, Ding Wang, Ding Wang, Xiangyu Chu, Xiangyu Chu, Xiangyu Chu, Longyuan Jia, Longyuan Jia, Longyuan Jia, Shijie Xin, Shijie Xin, Shijie Xin   +23 more
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The treatment choices of abdominal aortic aneurysm patients in China in the era of value-based healthcare

Frontiers in Cardiovascular Medicine, 2022
BackgroundEndovascular aneurysm repair (EVAR) is often seen as the first choice treatment for patients with abdominal aortic aneurysm (AAA), particularly high-risk patients, yet the long-term survival rate and improvement in quality of life are still ...
Liren Duan, Liren Duan, Wei Xin, Shenli Li, Lin Zhao, Shijie Xin, Shijie Xin   +6 more
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Abdominal Aortic Aneurysm: Roles of Inflammatory Cells

Frontiers in Immunology, 2021
Abdominal aortic aneurysms (AAAs) are local dilations of infrarenal segment of aortas. Molecular mechanisms underlying the pathogenesis of AAA remain not fully clear. However, inflammation has been considered as a central player in the development of AAA.
Zhen Yuan, Yi Lu, Jia Wei, Jiaqi Wu, Jin Yang, Zhejun Cai   +5 more
semanticscholar   +1 more source

Extracellular Tuning of Mitochondrial Respiration Leads to Aortic Aneurysm

Circulation, 2021
Supplemental Digital Content is available in the text. Background: Marfan syndrome (MFS) is an autosomal dominant disorder of the connective tissue caused by mutations in the FBN1 (fibrillin-1) gene encoding a large glycoprotein in the extracellular ...
J. Oller, Enrique Gabandé-Rodríguez, M. J. Ruíz-Rodríguez, Gabriela Desdín-Micó, J. Aranda, R. Rodrigues-Díez, C. Ballesteros-Martínez, E. Blanco, R. Roldán-Montero, P. Acuña, A. Forteza Gil, C. Martín-López, J. Nistal, C. L. Lino Cardenas, M. Lindsay, J. Martín-Ventura, A. Briones, Juan Miguel Redondo, M. Mittelbrunn   +18 more
semanticscholar   +1 more source

Melatonin Plays a Critical Protective Role in Nicotine-Related Abdominal Aortic Aneurysm

Frontiers in Physiology, 2020
Aim: Smoking is a major risk factor for abdominal aortic aneurysm (AAA). Among the components of smoke, nicotine is known to exert pro-atherosclerotic, prothrombotic, and proangiogenic effects on vascular smooth muscle cells (VSMCs).
Liren Duan, Shenli Li, Lei Wang, Yuchen Jing, Guangxin Li, Yaodong Sun, Weifeng Sun, Yalun Li, Lin Zhao, Shijie Xin   +9 more
doaj   +1 more source