Results 11 to 20 of about 114,095 (208)

Fluid-structure instability forecasts thoracic aortic aneurysm progression [PDF]

Nat. Biomed. Eng 7, 1614-1626 (2023), 2021
The basic mechanism driving aneurysm growth is unknown. Currently, clinical diagnosis of an aneurysm is mainly informed by retrospective tracking of its size and growth rate. However, aneurysms can rupture before reactive criteria are met or remain stable when they are exceeded.
arxiv   +1 more source

Mathematical modeling of shear-activated targeted nanoparticle drug delivery for the treatment of aortic diseases [PDF]

Biomechanics and Modeling in Mechanobiology (2021), 2021
The human aorta is a high-risk area for vascular diseases, which are commonly restored by thoracic endovascular aortic repair. In this paper, we report a promising shear-activated targeted nanoparticle drug delivery strategy to assist in the treatment of coarctation of the aorta and aortic aneurysm.
arxiv   +1 more source

Patient-specific Finite Element Modeling of Aneurysmal dilatation after chronic type B aortic dissection [PDF]

Computational Biomechanics for Medicine, Springer International Publishing, pp.15-38, 2022, 2023
Progressive aneurysmal dilatation is a well-recognized complication in patients with chronic type B aortic dissection (cTBAD), which may lead to a delayed rupture and create a life-threatening condition. However, our understanding of such aortic expansion in cTBAD remains weak.
arxiv   +1 more source

Treatment strategies for unruptured pancreaticoduodenal artery aneurysms associated with celiac artery occlusion

Annals of Gastroenterological Surgery, Volume 7, Issue 1, Page 182-189, January 2023., 2023
Since celiac artery occlusion represents a common attributable aetiology for these aneurysms, restoration of blood flow to the regions supplied by the celiac artery should also be taken into account when designing a treatment plan. Here, we present 4 cases of PDA aneurysms coexisting with coeliac artery occlusion, all of which were managed with bypass ...
Koji Kubota, Akira Shimizu, Tsuyoshi Notake, Yuko Wada, Yuji Soejima   +4 more
wiley   +1 more source

Romiplostim use in pregnant women with immune thrombocytopenia

American Journal of Hematology, Volume 98, Issue 1, Page 31-40, January 2023., 2023
Abstract Treatment for immune thrombocytopenia (ITP) in pregnancy is hampered by the lack of fetal safety evidence of maternally‐administered medications. The Pregnancy Surveillance Program (PSP) collected patient information from 2017–2020 for pregnancy, birth outcomes, and adverse events (AEs) for 186 women exposed to romiplostim from 20 days before ...
James B. Bussel, Nichola Cooper, Tatiana Lawrence, Marc Michel, Emilie Vander Haar, Kejia Wang, Hongmei Wang, Hossam Saad   +7 more
wiley   +1 more source

Familial Bainbridge‐Ropers syndrome: Report of familial ASXL3 inheritance and a milder phenotype

American Journal of Medical Genetics Part A, Volume 191, Issue 1, Page 29-36, January 2023., 2023
Abstract De novo truncating and splicing pathogenic variants in the Additional Sex Combs‐Like 3 (ASXL3) gene are known to cause neurodevelopmental delay, intellectual disability, behavioral difficulties, hypotonia, feeding problems and characteristic facial features.
Schaida Schirwani, Emily Woods, David A. Koolen, Charlotte W. Ockeloen, Sally Ann Lynch, Karl Kavanagh, John M. Graham Jr, Katheryn Grand, Tyler Mark Pierson, Jeffrey M. Chung, Meena Balasubramanian   +10 more
wiley   +1 more source

Comprehensive genetic screening for vascular Ehlers–Danlos syndrome through an amplification‐based next‐generation sequencing system

American Journal of Medical Genetics Part A, Volume 191, Issue 1, Page 37-51, January 2023., 2023
Abstract Vascular Ehlers–Danlos syndrome (vEDS) is a hereditary connective tissue disorder (HCTD) characterized by arterial dissection/aneurysm/rupture, sigmoid colon rupture, or uterine rupture. Diagnosis is confirmed by detecting heterozygous variants in COL3A1.
Tomomi Yamaguchi, Shujiro Hayashi, Daisuke Hayashi, Takeshi Matsuyama, Norimichi Koitabashi, Kenichi Ogiwara, Masaaki Noda, Chiai Nakada, Shinya Fujiki, Akira Furutachi, Yasuhiko Tanabe, Michiko Yamanaka, Aki Ishikawa, Miyako Mizukami, Asako Mizuguchi, Kazumitsu Sugiura, Makoto Sumi, Hirokuni Yamazawa, Atsushi Izawa, Yuko Wada, Tomomi Fujikawa, Yuri Takiguchi, Keiko Wakui, Kyoko Takano, Shin‐Ya Nishio, Tomoki Kosho   +25 more
wiley   +1 more source

Extracellular Matrix Targeted MRI Probes

Analysis &Sensing, Volume 3, Issue 1, January 2023., 2023
Gadolinium based MRI probes targeted to ECM components, either proteins or enzymes, hold promise for accurate molecular characterization and staging of fibrotic diseases in vivo. Non‐covalent binding probes (1), reactive probes (2), and enzyme‐responsive probes (3) are discussed.
Giuseppe Digilio, Sara Lacerda, Begoña Lavin Plaza, Alkystis Phinikaridou   +3 more
wiley   +1 more source

Hemodynamic effects of stent-graft introducer sheath during thoracic endovascular aortic repair [PDF]

Biomechanics and Modeling in Mechanobiology (2022), 2021
Thoracic endovascular aortic repair (TEVAR) has become the standard treatment of a variety of aortic pathologies. The objective of this study is to evaluate the hemodynamic effects of stent-graft introducer sheath during TEVAR. Three idealized representative diseased aortas of aortic aneurysm, coarctation of the aorta, and aortic dissection were ...
arxiv   +1 more source

Volume–outcome relationships in open and endovascular repair of abdominal aortic aneurysm: administrative data 2006–2018

BJS (British Journal of Surgery), EarlyView., 2020
This study used recent evidence to investigate and update volume–outcome relationships following open surgical repair (OSR) and endovascular repair (EVAR) of abdominal aortic aneurysm in England. Higher annual all‐procedure volumes were associated with significantly lower in‐hospital mortality for OSR, but such a relationship was not significant for ...
T. Tong, A. Aber, J. Chilcott, P. Thokala, S. J. Walters, R. Maheswaran, S. Nawaz, S. Thomas, J. Michaels   +8 more
wiley   +1 more source