Results 221 to 230 of about 110,567 (316)

USP5‐C‐MAF Axis Regulates Autophagy‐Dependent Neuronal Ferroptosis in Spinal Cord Injury Therapeutics

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
SCI induces significant upregulation of USP5 in neurons. The overexpressed USP5 stabilizes c‐MAF protein expression through its deubiquitinase activity, activating autophagy and accelerating the degradation of autophagic ferritin, thereby mediating neuronal ferroptosis. This ultimately leads to impaired functional recovery in SCI mice.
Shiyang Weng   +4 more
wiley   +1 more source

VSMC phenotypic switching in thoracic aortic aneurysm at single‐cell resolution: Trajectories, regulatory circuits, and spatial niches

open access: yesClinical and Translational Discovery, Volume 6, Issue 3, June 2026.
•Single‐cell/spatial multi‐omics identify four VSMC phenotypic states in TAA progression. •KLF4 as master hub (TGF‐β/TNF‐α/mechanical stress) orchestrating chromatin remodelling. •Pseudotime trajectories mapping contractile phenotypes towards osteogenic (RUNX2/SOX9) and inflammatory (TNF‐α/IL‐6) fates within spatial medial niches. •cfDNA biomarkers and
Zehua Shao   +6 more
wiley   +1 more source

Muscle Sparing Open Descending Thoracic Aortic Aneurysm Repair. [PDF]

open access: yesEJVES Vasc Forum
Ribé L, Tanaka A, Afifi RO, Estrera AL.
europepmc   +1 more source

Computational Rheo‐Hydrodynamic Analysis of Non‐Newtonian Blood Flow Through a Tilted Ellipsoidal Stenosed Vascular Segment

open access: yesEngineering Reports, Volume 8, Issue 6, June 2026.
Non‐Newtonian blood flow through multiple tilted ellipsoidal stenoses is numerically investigated using the DeKee‐Turcotte‐Papanastasiou model. The results reveal asymmetric velocity fields, elevated wall shear stress, significant pressure drops, and shear‐dependent thermal effects, highlighting the critical hemodynamic risks associated with eccentric ...
Azad Hussain, Huma Naz
wiley   +1 more source

Genetic Bone Diseases: A Scoping Review of Pathology, Symptoms, Diagnosis, Treatment, and New Horizons

open access: yesAdvanced Genetics, Volume 7, Issue 2, June 2026.
This review highlights six genetic diseases of the bone, aiming to provide clinicians and researchers with updated information on their diagnosis and treatment. It also includes an assessment of common clinical and radiographic findings, along with pathophysiology related to diseases.
Colin Jones, Ambalangodage C. Jayasuriya
wiley   +1 more source

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