Results 41 to 50 of about 945,421 (255)

The Comparison between Frozen Elephant Trunk Technique and Conventional Total Arch Replacement, a Single-center Study

Siriraj Medical Journal, 2022
Objective: The advantage of the frozen elephant trunk technique (FET) is treating the aortic pathology extending from the aortic arch to the descending aorta in a one-stage operation.
Amarit Phothikun, Dit Yoongtong, Weerachai Nawarawong, Surin Woragidpoonpol   +3 more
doaj   +1 more source

Plaque‐Hepatic Targeting Nanotherapy Disrupts the PCSK9‐LOX‐1 Axis to Suppress oxLDL in Atherosclerosis

Advanced Science, EarlyView.
Self‑amplifying PCSK9–LOX‑1 feedback axis drives atherosclerotic progression by promoting oxLDL generation and endothelial uptake. A dual‑targeting nanoplatform (siPCSK9@PEAL NPs‑aL) is constructed to simultaneously silence hepatic PCSK9 for lipid lowering and block plaque LOX‑1 for anti‑inflammation.
Yi Duan, Yijie Qiu, Yan Zhu, Quan Wang, Jiangtao Lin, Yourong Duan, Qi Wang, Yi Dong   +7 more
wiley   +1 more source

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

Advanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang, Jieyu Cui, Chunlu Huang, Wanyi Guo, Tong Liu, Yi Zhu, Shuai Shao, Kangyin Chen, Jinlong He, Qiankun Bao   +9 more
wiley   +1 more source

eComment. Total surgical aortic arch replacement [PDF]

Interactive CardioVascular and Thoracic Surgery, 2013
We would like to congratulate Czerny et al. for their very well written article and favourable results [1]. The authors conclude that open total aortic arch replacement shows very satisfying results, mainly due to improvements in perfusion technology, better surgical technique, and careful anesthesiology management.
Dimitrios V, Avgerinos, Iakovos, Panteliadis   +1 more
openaire   +2 more sources

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

Advanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu, Hongkun Wang, Jiawei Wang, Xiaolu Liu, Aerziguli Aierken, Lizhen Xu, Ping Liang, Fan Yang   +7 more
wiley   +1 more source

Dysphagia in an adult tetralogy of fallot with double aortic arch [PDF]

, 2013
Double aortic arch (DAA) is a common vascular ring. It may occur in isolation or coexist with various types of congenital heart disease . The anomaly usually presents in early infancy.
Bhan, Anil, Munesh, Tomar, Pankaj, Bhatiya   +2 more
core  

Total arch replacement for aortic arch aneurysm with coexisting middle aortic syndrome

International Journal of Surgery Case Reports, 2019
Middle aortic syndrome (MAS) combined with thoracic aortic aneurysm (TAA) is a rare vascular disease. One stage open surgery to treat this condition, becomes a challenge for our cardiovascular surgery.A 69-year-old man presented with a saccular type aortic arch aneurysm, shaggy aorta and severe atherosclerotic stenosis of the thoracoabdominal aorta ...
Yu, Zaiqiang, Minakawa, Masahito, Kondo, Norihiro, Daitoku, Kazuyuki, Fukuda, Ikuo   +4 more
openaire   +2 more sources

MAPA: A Semantic Network Framework for Functional Module Discovery and Interpretation in Multi‐Omics Data

Advanced Science, EarlyView.
MAPA transforms complex multi‐omics data into biologically coherent functional modules by integrating pathway information with molecular interaction networks. Retrieval‐augmented large language models then generate structured, literature‐informed interpretations.
Yifei Ge, Feifan Zhang, Yijiang Liu, Chao Jiang, Peng Gao, Nguan Soon Tan, Sai Zhang, Yuchen Shen, Qianyi Zhou, Xin Zhou, Xiao Wang, Fangqing Zhao, Chuchu Wang, Xiaotao Shen   +13 more
wiley   +1 more source

Total surgical aortic arch replacement as a safe strategy to treat complex multisegmental proximal thoracic aortic pathology.

, 2013
OBJECTIVE To analyse the results after elective open total aortic arch replacement. METHODS We analysed 39 patients (median age 63 years, median logistic EuroSCORE 18.4) who underwent elective open total arch replacement between 2005 and 2012.
Czerny, Martin, Schönhoff, Florian, Basciani, Reto Marco, Carrel, Thierry, König, Tobias, Rieger, Maximilian, Jenni, Hansjörg, Reineke, David Christian, Sodeck, Gottfried H., Schmidli, Jürg   +9 more
core   +1 more source

Total resection of an infected aortic arch aneurysm caused by Mycobacterium avium: a case report

Journal of Cardiothoracic Surgery, 2019
Background Infected aortic arch aneurysms caused by Mycobacterium avium are rare in immunocompetent individuals. Promptly recognizing these aneurysms is important because delays in treatment result in aneurysm rupture and a high fatality rate.
Kei Yagami, Takashi Fujita, Shinichi Ishida, Masato Mutsuga   +3 more
doaj   +1 more source