Results 141 to 150 of about 479,259 (314)

Muscle-sparing extrapleural repair of neonatal aortic coarctation

, 2018
The goal of surgical treatment of aortic coarctation is to relieve the pressure gradient on the aorta and to allow for subsequent growth of the repaired aorta.
Pfister, Raymond, Berset, Stéphanie, Prêtre, René, Sologashvili, Tornike, Nowacka, Anna, Myers, Patrick O   +5 more
core   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Transcutaneous angioplasty of experimental aortic coarctation.

, 1982
A dilatable form of juxtaductal aortic coarctation was surgically created in 29 newborn lambs. Of the 17 long-term survivors, four lambs served as controls and 13 underwent transcutaneous balloon dilation angioplasty with either polyvinylchloride or ...
W R Castaneda-Zuniga, T Niemi, S Einzig, J E Lock, B A Burke   +4 more
core   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

Technique of interventional repair in adult aortic coarctation

, 2010
Surgical treatment of aortic coarctation has increased life expectancy and reduced mortality. Unfortunately, the average lifespan after repair remains only 35 to 50 years, and significant morbidity persists as a result of aneurysm formation, hypertension,
Ince, Hüseyin, Schneider, Henrik, Ortak, Jasmin, Nienaber, Christoph A., Kische, Stephan, Akin, Ibrahim, Rehders, Tim C., Chatterjee, Tushar   +7 more
core   +1 more source

Gβγ subunit activation of KV7 and BKCa channels underlies calcitonin gene‐related peptide vasorelaxation in myogenic rat coronary resistance arteries

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose CGRP is a potent, clinically relevant coronary vasodilator known to play a role in cardioprotection. Here, we investigated the precise intracellular signalling pathways leading to vasodilation in small coronary arteries.
Lucy A. Donovan, JinHeng Lin, Milind Khashu, Christopher J. Garland, Kim A. Dora   +4 more
wiley   +1 more source

Saccular distal aorta aneurysm accompanying aortic coarctation [PDF]

, 2006
Aortun konjenital darlıgı olan aort koarktasyonu, sıklıkla inen aortun proksimal kesimini tutar. Aort koarktasyonuna eslik eden serebral anevrizmalar ve koarkte segmentin proksimalindeki aort anevrizmaları, göreceli sık rastlanan komplikasyonlar ...
Kazak, Eda, Karaman, Can Zafer, Ünsal, Alparslan   +2 more
core  

Congenital Coarctation of the Aorta in a Patient With ROBO4 c.695C>T (p.Thr232Met) Germline Variant

Annals of Internal Medicine: Clinical Cases
Roundabout guidance receptor 4 (ROBO4) germline variants [including c.695C>T (p.Thr232Met)] have been linked with bicuspid aortic valve and thoracic aortic aneurysm. However, the precise nature of ROBO4’s role in aortopathy is yet to be fully defined. We
Mohammad Karam Chaaban, George Bcharah, Bukola A. Olarewaju, Linnea M. Baudhuin, Fadi Shamoun, Mayowa A. Osundiji   +5 more
doaj   +1 more source

Endothelium‐ and epithelium‐derived novel endogenous catecholamines as modulators of the autonomic nervous system

British Journal of Pharmacology, EarlyView.
Abstract Catecholamines are classically viewed as neuronal transmitters and adrenal hormones; however, accumulating evidence demonstrates that sources other than nerve fibres and adrenal medulla play a fundamental role in local organ regulation. Physiological paradoxes, such as preserved organ function after denervation or transplantation, challenge a ...
Mariana G. de Oliveira, Edson Antunes, Fabiola Zakia Monica, Gilberto De Nucci   +3 more
wiley   +1 more source

Recurrent aortic coarctation: Is surgical repair still the gold standard?

, 1998
Objective: We reviewed our experience with surgical repair compared with balloon aortoplasty of recurrent coarctations of the aorta. Methods: This is a retrospective review of 1 institution's 27-year experience with surgical repair of recurrent aortic ...
Sakopoulos, Andreas G., Brown, John W., Hahn, Tara L., Turrentine, Mark   +3 more
core   +1 more source