Obesity‐Associated Adiposomes Promote Vascular Smooth Muscle Cell Hypercontractility
Comprehensive Physiology, Volume 15, Issue 5, October 2025.Ceramide‐rich adiposomes released from dysfunctional adipose tissue in obesity mediate adipose–vascular crosstalk. These vesicles promote ROS generation, disrupt KATP channel activity, and dysregulate Ca2+ signaling, leading to vascular smooth muscle hypercontractility and vascular dysfunction.
Elsayed Metwally +11 more
wiley +1 more source
Case Report: Simultaneous covered stenting for aortic coarctation and significant PDA in low and very low birth weight preterm infants: technical insights from two cases. [PDF]
Front Cardiovasc MedMini N +4 more
europepmc +1 more source
End-to-side anastomosis and autologous pulmonary artery patch for aortic coarctation and hypoplastic aortic arch. [PDF]
J Thorac DisZhao Z +7 more
europepmc +1 more source
Genetic insights into congenital heart disease: Prevalence, aetiology and clinical implications
Clinical and Translational Discovery, Volume 5, Issue 5, October 2025.The review synthesizes current knowledge on the genetic underpinnings of congenital heart disease, highlighting how modern genomic technologies enhance understanding of CHD pathogenesis and enable earlier diagnosis. We demonstrate how these genetic insights translate to improved clinical care, risk assessment, and genetic counseling for affected ...
Yuan Yuan +8 more
wiley +1 more source
Enhancing Early Detection of Aortic Coarctation With Perfusion Index: A Report of Two Cases. [PDF]
CureusGomes Pereira P +4 more
europepmc +1 more source
Aortic stenosis intricacies beyond the valve: A bidirectional Mendelian randomization study
ESC Heart Failure, Volume 12, Issue 5, Page 3276-3284, October 2025.Abstract Aims Numerous observational studies have reported an association between calcific aortic valve stenosis (CAVS) and an increased risk of other cardiovascular diseases (CVDs). However, the potential causal association is uncertain. Methods and results A bidirectional Mendelian randomization (MR) analysis was performed to confirm the causal ...
Dihui Cai, Jianhui Liu
wiley +1 more source
Evaluation of Children with Aortic Coarctation: A Single-Center Experience. [PDF]
Turk Arch PediatrTürkmen H +4 more
europepmc +1 more source
ESC Heart Failure, Volume 12, Issue 5, Page 3601-3613, October 2025.Abstract Aims Targeting inflammasomes in heart failure (HF) might represent a novel therapeutic option. Nevertheless, previous studies focused only on myocardial inflammasome alterations, and data are scarce regarding their regulation and role in HF‐associated multiorgan dysfunction.
Dávid Nagy +12 more
wiley +1 more source
Association of Plasma Renin Activity with Risk of Late Hypertension in Pediatric Patients with Early Aortic Coarctation Repair: A Retrospective Study. [PDF]
Life (Basel)Margarint IM +9 more
europepmc +1 more source
ESC Heart Failure, Volume 12, Issue 5, Page 3655-3666, October 2025.Analysis of the usage of the HFA‐PEFF score‐based clinical decision support system (CDSS) and the main barriers and facilitators to its implementation, based on a survey of physicians. Abstract Background and aims Knowing that heart failure (HF) with preserved ejection fraction (HFpEF) can be difficult to diagnose, a clinical decision support system ...
Isidora Milosavljević +29 more
wiley +1 more source