Results 221 to 230 of about 77,172 (303)
Hederagenin Attenuates Cardiac Remodeling by Targeting Phosphodiesterase 9A
ABSTRACT Background and Aim New therapeutic strategies for heart failure are urgently needed. The protective effects of cyclic guanosine monophosphate (cGMP)—protein kinase G (PKG) pathway on heart have been widely reported. Despite phosphodiesterase 9A (PDE9A) inhibitors combating cardiac remodeling, clinically available drugs are lacking. Hederagenin
Liqian Chen +16 more
wiley +1 more source
Prenatal detection and outcome of major heart defects in a country with universal screening
ABSTRACT Objective To evaluate the Danish prenatal screening program for major fetal congenital heart defects (mCHD), focusing on incidence, detection rates (DRs), pregnancy outcomes and postnatal mortality. Methods This was a 5‐year nationwide cohort study conducted from January 2018 to December 2022 in Denmark.
C. Vedel +15 more
wiley +1 more source
Aortic dilatation in children with mild to moderate chronic kidney disease. [PDF]
Madueme PC +8 more
europepmc +1 more source
Exploratory Laparotomy After Routine Cardiac Surgery: Results From 17,000 Patients
Exploratory laparotomy is rare after open‐heart surgery, and it was performed for gastrointestinal complications that occurred in the context of other severe postoperative complications. Several factors were associated with the need for exlap, including increasing age, pre‐existing renal and vascular disease, and pre‐ and post‐operative shock. ABSTRACT
Megan Turner +16 more
wiley +1 more source
ABSTRACT The objective was to prepare guidelines to perform the current optimum treatment by organizing effective and efficient treatments of hemangiomas and vascular malformations, confirming the safety, and systematizing treatment, employing evidence‐based medicine techniques and aimed at improvement of the outcomes.
Yoshiaki Kinoshita +116 more
wiley +1 more source
Abstract Fetal autopsy remains essential for determining the cause of intrauterine death and for supporting clinical, genetic, and forensic evaluations. However, in cases of advanced maceration, autolysis severely compromises tissue integrity, often preventing adequate identification of anatomical structures and limiting the diagnostic and medico‐legal
Francesca Buffelli +4 more
wiley +1 more source
A smaller heart-aorta-angle associates with ascending aortic dilatation and increases wall shear stress. [PDF]
Kauhanen SP +7 more
europepmc +1 more source
Interventional oncology in children: Where are we now?
Abstract Paediatric Interventional Oncology (IO) lags behind adult IO due to a scarcity of specific outcome data. The suboptimal way to evolve this field is relying heavily on adult experiences. The distinct tumour types prevalent in children, such as extracranial germ cell tumours, sarcomas, and neuroblastoma, differ strongly from those found in ...
Premal Amrishkumar Patel +1 more
wiley +1 more source

