Results 71 to 80 of about 77,172 (303)

Aortic Valve Stenosis Alters Expression of Regional Aortic Wall Shear Stress: New Insights From a 4‐Dimensional Flow Magnetic Resonance Imaging Study of 571 Subjects

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundWall shear stress (WSS) is a stimulus for vessel wall remodeling. Differences in ascending aorta (AAo) hemodynamics have been reported between bicuspid aortic valve (BAV) and tricuspid aortic valve patients with aortic dilatation, but the ...
Pim van Ooij, Michael Markl, Jeremy D. Collins, James C. Carr, Cynthia Rigsby, Robert O. Bonow, S. Chris Malaisrie, Patrick M. McCarthy, Paul W.M. Fedak, Alex J. Barker   +9 more
doaj   +1 more source

TAVI with the ACURATE neo transcatheter heart valve in special populations: A systematic review

Hellenic Journal of Cardiology, 2022
The ACURATE neo transcatheter aortic valve is a self-expanding device suitable for both transfemoral and transapical approach, but specific groups of patients are under-represented in clinical trials.
Leonidas Koliastasis, Ioannis Doundoulakis, Damianos G. Kokkinidis, Anastasios Milkas, Maria Drakopoulou, George Benetos, Georgios Latsios, Andreas Synetos, Konstantina Aggeli, Dimitrios Tousoulis, Konstantinos Tsioufis, Konstantinos Toutouzas   +11 more
doaj   +1 more source

The endothelial glycocalyx prefers albumin for evoking shear stress-induced, nitric oxide-mediated coronary dilatation [PDF]

, 2007
Background: Shear stress induces coronary dilatation via production of nitric oxide ( NO). This should involve the endothelial glycocalyx ( EG). A greater effect was expected of albumin versus hydroxyethyl starch ( HES) perfusion, because albumin seals ...
Bernhard F. Becker, Chang YS, Desjardins C, Dirk Bruegger, Gonzalez-Castillo C, Huxley VH, Joern O. Paul, Kuchan MJ, Leipert B, Markus Rehm, Matthias Jacob, Michael Loetsch, Mochizuki S, Mulivor AW, Peter Conzen, Platts SH, Pohl U, Pries AR, Risau W, Rubanyi GM, Siegel G, Ulrich Welsch, van Haaren P, Vink H, Vink H, Vink H   +25 more
core   +1 more source

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

The Role of Cardiac Magnetic Resonance Imaging in the Determination of Cardiovascular Anomalies in Children and Young Adults with Turner Syndrome

Journal of Pediatric Research, 2019
Aim:Congenital cardiovascular (CV) anomalies and aortic dilatation are common in patients with Turner syndrome. The aim of this study was to compare echocardiography (ECHO) findings with CV anomalies and aortic dilatation identified using magnetic ...
Özlem Korkmaz, Recep Savaş, Ertürk Levent, Samim Özen, İlkin Mecidov, Damla Gökşen, Şükran Darcan   +6 more
doaj   +1 more source

A Soft Robotic Model for Simulating Heart Valve Disease and Cardiac Interventions

Advanced Science, EarlyView.
This paper introduces a fully synthetic fabrication methodology for a soft robotic, in‐vitro model of the left‐heart, complete with a functioning mitral valve apparatus. With a view towards patient‐specific modeling, we demonstrate physiological flow and pressure waveforms, tunable mitral valve function with clinical imaging compatibility, and its use ...
James Davies, Emanuele Nicotra, Kefan Zhu, Chi Cong Nguyen, Bibhu Sharma, Adrienne Ji, Phuoc Thien Phan, Jingjing Wan, Patrick Pruscino, Hermione Truong, Jelena Rnjak‐Kovacina, Hoang‐Phuong Phan, Christopher Hayward, Nigel Hamilton Lovell, Thanh Nho Do   +14 more
wiley   +1 more source

Disruption of Osteoprotegerin has complex effects on medial destruction and adventitial fibrosis during mouse abdominal aortic aneurysm formation.

PLoS ONE, 2020
Aortic aneurysm refers to dilatation of the aorta due to loss of elasticity and degenerative weakening of its wall. A preventive role for osteoprotegerin (Opg) in the development of abdominal aortic aneurysm has been reported in the CaCl2-induced ...
Batmunkh Bumdelger, Mikage Otani, Kohei Karasaki, Chiemi Sakai, Mari Ishida, Hiroki Kokubo, Masao Yoshizumi   +6 more
doaj   +1 more source

Treatment of denture-related stomatitis improves endothelial function assessed by flow-mediated vascular dilation [PDF]

, 2016
Introduction: The presence of oral inflammation has recently been linked with the pathogenesis of cardiovascular diseases. While numerous studies have described links between periodontitis and endothelial dysfunction, little is known about the influence ...
Czesnikiewicz-Guzik, Marta, Dembowska, Elżbieta, Guzik, Tomasz, Loster, Jolanta, Maciąg, Anna, Maciąg, Joanna, Nowakowski, Daniel, Osmenda, Grzegorz, Robertson, Douglas, Wilk, Grzegorz   +9 more
core   +3 more sources

Endothelial GPR68 Is Essential for Arteriogenesis and Represents a Therapeutic Target in a Model of Peripheral Artery Disease

Advanced Science, EarlyView.
Endothelial GPR68 is identified as a critical regulator of collateral artery growth in peripheral artery disease. Genetic and pharmacological evidence demonstrates that GPR68 integrates hemodynamic cues to drive monocyte recruitment and inflammatory remodeling, thereby promoting collateral arteriogenesis and tissue perfusion after ischemia ...
Yiyan Song, Senyi Peng, Zhilei Huang, Miao Yu, Mingyue Wu, Yuexin Zhu, Zeyi Zhou, Yongshan Liu, Yalin Zhang, Yu Huang, Zhongxing Wang, Fu‐Li Xiang, Jie Xu   +12 more
wiley   +1 more source

Hemodynamic predictors of aortic dilatation in bicuspid aortic valve by velocity-encoded cardiovascular magnetic resonance

Journal of Cardiovascular Magnetic Resonance, 2010
Background Congenital Bicuspid Aortic Valve (BAV) is a significant risk factor for serious complications including valve dysfunction, aortic dilatation, dissection, and sudden death.
Ramamurthy Senthil, Parks W James, Zaaijer Eline R, van der Velden Petra, Sallee Denver, den Reijer P Martijn, Robbie Trevor Q, Donati Giorgina, Lamphier Carey, Beekman Rudolf P, Brummer Marijn E   +10 more
doaj   +1 more source