Results 171 to 180 of about 119,594 (307)
Hederagenin Attenuates Cardiac Remodeling by Targeting Phosphodiesterase 9A
ABSTRACT Background and Aim New therapeutic strategies for heart failure are urgently needed. The protective effects of cyclic guanosine monophosphate (cGMP)—protein kinase G (PKG) pathway on heart have been widely reported. Despite phosphodiesterase 9A (PDE9A) inhibitors combating cardiac remodeling, clinically available drugs are lacking. Hederagenin
Liqian Chen +16 more
wiley +1 more source
Prognostic Value of a Composite Inflammation-Renal Function Score in Type A Aortic Dissection. [PDF]
Zhou RQ, Peng YD, Cai H, Zhang C, Wu QC.
europepmc +1 more source
Betulin Protects Against Cardiac Hypertrophy by Improving AMPK/Nrf2‐Dependent Mitochondrial Function
Betulin effectively mitigates pressure overload‐induced cardiac hypertrophy in both Ang II‐infused and TAC‐operated mice. Mechanistically, betulin activated AMPK phosphorylation, promoted Nrf2 nuclear translocation, and upregulated antioxidant genes (HO‐1 and NQO‐1), thereby restoring mitochondrial function in cardiomyocytes.
Bei Zheng +8 more
wiley +1 more source
Rapid bedside multimodal ultrasound screening for acute type A aortic dissection: a perspective. [PDF]
Xu H, Yang JY.
europepmc +1 more source
Type-A Aortic Dissection Evading Aortic Dissection Detection Score in Vulnerable Patient: A Case Report. [PDF]
Wehking F +2 more
europepmc +1 more source
ABSTRACT The objective was to prepare guidelines to perform the current optimum treatment by organizing effective and efficient treatments of hemangiomas and vascular malformations, confirming the safety, and systematizing treatment, employing evidence‐based medicine techniques and aimed at improvement of the outcomes.
Yoshiaki Kinoshita +116 more
wiley +1 more source
Fibrinogen-Bmal1 signaling as a therapeutic target to limit aortic dissection by preserving VSMC contractility. [PDF]
Zhong X +16 more
europepmc +1 more source
Abstract Fetal autopsy remains essential for determining the cause of intrauterine death and for supporting clinical, genetic, and forensic evaluations. However, in cases of advanced maceration, autolysis severely compromises tissue integrity, often preventing adequate identification of anatomical structures and limiting the diagnostic and medico‐legal
Francesca Buffelli +4 more
wiley +1 more source
Clinical features of pregnancy-associated aortic dissection and pregnancy outcomes. [PDF]
Ke M, Yu J, Li L, Qian L, Wang G.
europepmc +1 more source

