Results 171 to 180 of about 119,594 (307)

Return to Work After Type A Aortic Dissection. [PDF]

open access: yesCureus
Billy MJ   +7 more
europepmc   +1 more source

Hederagenin Attenuates Cardiac Remodeling by Targeting Phosphodiesterase 9A

open access: yesPhytotherapy Research, EarlyView.
ABSTRACT Background and Aim New therapeutic strategies for heart failure are urgently needed. The protective effects of cyclic guanosine monophosphate (cGMP)—protein kinase G (PKG) pathway on heart have been widely reported. Despite phosphodiesterase 9A (PDE9A) inhibitors combating cardiac remodeling, clinically available drugs are lacking. Hederagenin
Liqian Chen   +16 more
wiley   +1 more source

Betulin Protects Against Cardiac Hypertrophy by Improving AMPK/Nrf2‐Dependent Mitochondrial Function

open access: yesPhytotherapy Research, EarlyView.
Betulin effectively mitigates pressure overload‐induced cardiac hypertrophy in both Ang II‐infused and TAC‐operated mice. Mechanistically, betulin activated AMPK phosphorylation, promoted Nrf2 nuclear translocation, and upregulated antioxidant genes (HO‐1 and NQO‐1), thereby restoring mitochondrial function in cardiomyocytes.
Bei Zheng   +8 more
wiley   +1 more source

Japanese Clinical Practice Guidelines for Vascular Tumors, Vascular Malformations, Lymphatic Malformations, and Lymphangiomatosis 2022

open access: yesThe Journal of Dermatology, EarlyView.
ABSTRACT The objective was to prepare guidelines to perform the current optimum treatment by organizing effective and efficient treatments of hemangiomas and vascular malformations, confirming the safety, and systematizing treatment, employing evidence‐based medicine techniques and aimed at improvement of the outcomes.
Yoshiaki Kinoshita   +116 more
wiley   +1 more source

Fibrinogen-Bmal1 signaling as a therapeutic target to limit aortic dissection by preserving VSMC contractility. [PDF]

open access: yesSignal Transduct Target Ther
Zhong X   +16 more
europepmc   +1 more source

Advancing fetal autopsy in cases of maceration: Underwater dissection technique and its forensic relevance

open access: yesJournal of Forensic Sciences, EarlyView.
Abstract Fetal autopsy remains essential for determining the cause of intrauterine death and for supporting clinical, genetic, and forensic evaluations. However, in cases of advanced maceration, autolysis severely compromises tissue integrity, often preventing adequate identification of anatomical structures and limiting the diagnostic and medico‐legal
Francesca Buffelli   +4 more
wiley   +1 more source

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