Results 341 to 350 of about 746,342 (406)

Techniques of liver transplantation [PDF]

, 1994
Casavilla, A, Gordon, RD, Starzl, TE
core  

Clinically relevant niclosamide concentrations modulate TMEM16A and CaV1.2 channels to control artery tone and capillary diameter

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose TMEM16A Ca2+‐gated Cl− channels mediate depolarisation of contractile vascular cells. The anthelmintic niclosamide was reported to modulate the TMEM16A channel, suggesting possible repurposing for vascular pharmacology. Here, we investigate the mechanism of TMEM16A modulation by niclosamide and explore its effect on the ...
Rachel Kaye, Claire Pearson, Tibyan Babiker, Emilio Agostinelli, Rumaitha Al‐Hosni, Paolo Tammaro   +5 more
wiley   +1 more source

[MSB-14] Validation of the German Registry for Acute Aortic Dissection Type A Score After Aortic Dissection Surgery. [PDF]

Turk Gogus Kalp Damar Cerrahisi Derg
Salihi S, Özalp B, Yazıcı YE, Kalender M, Saçlı H, Kara İ.   +5 more
europepmc   +1 more source

NAPaR : European non-interventional post-authorisation safety study of pattern of use and safety of Nordic aprotinin [PDF]

, 2019
De Hert, Stefan, Ouattara, A., Royston, D., Van Der Linden, J., Zacharowski, K.   +4 more
core  

Stabilisation of PRCP by deubiquitinase‐targeting chimera (DUBTAC) to replenish autophagy for ameliorating pathological cardiac hypertrophy

British Journal of Pharmacology, EarlyView.
Background and Purpose Autophagy is essential for cellular homeostasis, and its impairment contributes to cardiac hypertrophy. Modulating autophagy has shown potential in treating pathological hypertrophy. Prolylcarboxypeptidase (PRCP), a lysosomal enzyme that hydrolyzes angiotensin II to Ang1‐7, has an unclear role in cardiac autophagy and hypertrophy.
Fangchao Zhou, Jun Xia, Yingjuan Liu, Wenqi He, Hongyuan Zhang, Bernard D. Keavney, Min Zi, Binh Y. Nguyen, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Susanne S. Hille, Elizabeth J. Cartwright, Oliver J. Müller, Honglin Xu, Sam Butterworth, Xin Wang   +16 more
wiley   +1 more source

Biomarkers to predict the outcomes of surgical intervention for aortic dissection. [PDF]

J Cardiothorac Surg
Hanna AG, Contreras FJ, Sharaf OM, Stinson GP, Hess PJ.   +4 more
europepmc   +1 more source

The thoracic perivascular adipose tissue spontaneously induces vasoconstriction through activation of α1‐adrenoceptors

British Journal of Pharmacology, EarlyView.
Background and Purpose Although perivascular adipose tissue (PVAT) contains substances with contractile properties, its actions on the vascular tone are associated with the release of anticontractile substances. We hypothesize that procontractile PVAT products also exert direct effects on vascular tone. Experimental Approach Thoracic aortas from Wistar
Leonardo Gomes‐Pereira, José Eduardo da Silva‐Santos   +1 more
wiley   +1 more source

Comparison of outcomes between axillary and femoral artery cannulation for type A aortic dissection surgery. [PDF]

J Cardiothorac Surg
Wang Z, Yu Y, Xie X, Wan L, Wang L, Yin J.   +5 more
europepmc   +1 more source

Effect of 3‐mercaptopyruvate sulfurtransferase (3‐MST) inhibitors on contractile responses in porcine coronary artery

British Journal of Pharmacology, EarlyView.
Background and Purpose Hydrogen sulphide (H2S) is synthesised endogenously through cystathionine β‐synthase (CBS), cystathionine γ‐lyase (CSE) and 3‐mercaptopyruvate sulfurtransferase (3‐MST). Although exogenous H2S is known to produce vasodilatation, the vascular effect of H2S produced through 3‐MST is unknown. In this study, we demonstrate the effect
Maha Almaheize, Sahar Alharthi, Patricia Hemp, Jennifer Mattos, Marcus van Leer, Michael Garle, Stephen Alexander, Richard Roberts   +7 more
wiley   +1 more source

Preoperative Mechanical Ventilation Prior to Surgical Repair for Type A Aortic Dissection: Incidence, Risk, and Outcomes. [PDF]

J Cardiovasc Dev Dis
Dell'Aquila AM, Wisniewski K, Georgevici AI, Szabó G, Onorati F, Demal TJ, Rukosujew A, Peterss S, Radner C, Buech J, Fiore A, Perrotti A, Pinto AG, Rodriguez Lega J, Pol M, Kacer P, Mazzaro E, Gatti G, Vendramin I, Piani D, Ferrante L, Rinaldi M, Quintana E, Pruna-Guillen R, Di Perna D, El-Dean Z, Sherzad H, Mariscalco G, Field M, Harky A, Kuduvalli M, Pettinari M, Rosato S, Juvonen T, Mäkikallio T, Conradi L, Mastroiacovo G, Biancari F.   +37 more
europepmc   +1 more source