Results 261 to 270 of about 92,271 (323)

Pulmonary Vascular Endothelial Cells in Lung Diseases: Mechanisms, Therapeutic Strategies, and Future Directions

Cell Proliferation, EarlyView.
The pathogenic mechanisms of pulmonary vascular endothelial cells (VECs) in lung diseases and their multimodal therapeutic strategies. ABSTRACT Pulmonary vascular endothelial cells (VECs) are essential for the normal function of the lung, through maintaining vascular barrier integrity, regulating blood flow, and participating in inflammatory responses ...
Qianyue Liu, Hongshuai Zheng, Jing Liu, Ming Gao, Faquan Lin, Lin Liao   +5 more
wiley   +1 more source

Dimerization‐dependent NOTCH receptor transactivation unveils a class of highly selective NOTCH signalling inhibitors

The FEBS Journal, EarlyView.
NOTCH signalling is indispensable for tissue homeostasis and, consequently, corruption of its normal function promotes numerous diseases, including cancer. However, the development of targeted therapies has been hampered by inefficacy and overt toxicity. Here, we show that NOTCH receptor dimerization is necessary for receptor transactivation, which has
Xinxin Liu, Haijiang Wang, Gunja Mishra, Lin‐Ting Wu, Chao Li, Maarten van Dinther, Jin Liu, Manuel A.F.V. Gonçalves, Peter ten Dijke, David A. Baker   +9 more
wiley   +1 more source

AB138. SOH24AB_116. Emergency transcatheter aortic valve implantation in acute decompensated heart failure with multi-organ failure due to aortic insufficiency: a case report

P Widdes Walsh, Carlos Sebastian Gracias, Cormac O’Connor   +2 more
openalex   +1 more source

Comparative analysis of metabolic and functional cardiac alterations in diet‐ and genetically induced mouse models of cardiac dysfunction

The FEBS Journal, EarlyView.
Dietary and genetic stress trigger different routes to heart failure. In mice, a carbohydrate‐free high‐fat diet caused mitochondrial dysfunction and impaired energy production with preserved pumping function, while genetic obesity led to heart enlargement, fibrosis, and reduced function.
Christiane Ott, Patricia Baumgarten, Thorsten Henning, Daniela Weber, Iwona Wallach, Jana Grune, Ulrich Kintscher, Hermann‐Georg Holzhütter, Tilman Grune, Nikolaus Berndt   +9 more
wiley   +1 more source

Features of method of medical physical culture at insufficiency of aortic valve

, 2013
Kalmykov S.A.
openalex   +2 more sources

Efficacy and Safety of Hypofractionated Radiation Therapy Combined With Immunotherapy for Hepatocellular Carcinoma With Vp4 Portal Vein Tumor Thrombosis

Hepatology Research, EarlyView.
ABSTRACT Background Hepatocellular carcinoma (HCC) with Vp4 portal vein tumor thrombosis (PVTT) has an extremely poor prognosis, and evidence for effective systemic therapy is limited. Preclinical studies suggest that hypofractionated radiation therapy (HFRT) may enhance immune checkpoint inhibitor (ICI) efficacy through immunogenic cell death and ...
Masahiko Tameda, Hideaki Tanaka, Yutaka Toyomasu, Mizuki Kawachi, Hirono Owa, Mone Tsukimoto, Yasuyuki Tamai, Naoto Fujiwara, Ryuta Shigefuku, Suguru Ogura, Yoshihito Nomoto, Hayato Nakagawa   +11 more
wiley   +1 more source

A Retrospective Study of Adult and Pediatric D‐Dimer Tests to Identify Opportunities for Improved Utilization

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction D‐dimers are produced by lysis of cross‐linked fibrin. In children, D‐dimer testing is used to evaluate disseminated intravascular coagulation (DIC) and some inflammatory states, but its use is not validated for screening or ruling out suspected venous thromboembolic events (VTE).
Rabab Al Dawood, Hassan Abu Sabah, Natalie Mathews, James Douketis, Catherine Hayward   +4 more
wiley   +1 more source

Healthcare Professionals' Descriptions of Contextual Factors Affecting Complex Aortic Surgical Care: A Secondary Analysis Using the Fundamentals of Care Framework

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To explore how factors in the complex aortic surgical care context can affect care provision towards patients' postoperative recovery. Design Secondary qualitative analysis. Methods Results about patients' recovery after complex aortic surgery was presented in focus groups with healthcare professionals in 2022. Reflexive thematic analysis,
Linda Haakseth, Caisa Öster, Kevin Mani, Anders Wanhainen, Eva Jangland   +4 more
wiley   +1 more source

Annual Research Review: What processes are dysregulated among emotionally dysregulated youth? – a systematic review

Journal of Child Psychology and Psychiatry, Volume 66, Issue 4, Page 516-546, April 2025.
Proliferation of the term “emotion dysregulation” in child psychopathology parallels the growing interest in processes that influence negative emotional reactivity. While it commonly refers to a clinical phenotype where intense anger leads to behavioral dyscontrol, the term implies etiology because anything that is dysregulated requires an impaired ...
Joseph C. Blader, Amy S. Garrett, Steven R. Pliszka   +2 more
wiley   +1 more source