Results 51 to 60 of about 75,717 (282)

LncRNA Foxo6os as a Novel “ Scaffold” Mediates MYBPC3 in Combating Pathological Cardiac Hypertrophy and Heart Failure

Advanced Science, EarlyView.
Schematic overview showing that forkhead box O6, opposite strand (Foxo6os) acts as a “scaffold”, directly binding myosin‐binding protein‐C (MYBPC3) and recruiting protein kinase C (PKC‐α) to mediate site‐specific phosphorylation of MYBPC3. This post‐translational modification supports cardiac contraction by regulating L‐type Ca2+ channels, especially ...
Jie Sheng, Qin Lin, Yizhuo Sun, Yilei Meng, Sangyu Hu, Huaming Cao, Fang Lin, Yuping Zhu, Luying Peng, Li Li   +9 more
wiley   +1 more source

Loss of Hepatic Angiotensinogen Attenuates Diastolic Dysfunction in Heart Failure with Preserved Ejection Fraction

Advanced Science, EarlyView.
Increased hepatic angiotensinogen (AGT) abundance leads to cardiac diastolic dysfunction via the AngII‐independent pathway. Liver‐derived AGT is internalized by LRP2 in cardiac endothelial cells, subsequently contributing to myocardial diastolic dysfunction by suppressing microvascular angiogenesis via inhibiting the GATA2/Pim3 pathway.
Zetao Heng, Min Hong, Zhaocai Zhang, Ximing Ye, Jianan Zhou, Wentao Wu, Jiabing Rong, Yinchuan Xu   +7 more
wiley   +1 more source

Brucella endocarditis of the aortic valve [PDF]

, 1998
Brucella endocarditis was diagnosed in two patients with acute renal failure. Both patients had major aortic insufficiency, congestive cardiac failure and clinical and laboratory signs of an active infection, although adequate antibacterial therapy had ...
Antunes, MJ, Leandro, J, Roberto, H
core   +1 more source

Biodegradable Medical Implants: Reshaping Future Medical Practice

Advanced Science, EarlyView.
Biodegradable medical implants are transforming future healthcare by providing sustainable, biocompatible solutions that eliminate secondary removal procedures, enhancing patients’ physical and psychological comfort, and reducing economic burdens.
Bo Xia, Yan Liu, Yangkun Xing, Zhewei Shi, Xiaocheng Pan   +4 more
wiley   +1 more source

Open Challenges and Opportunities in Piezoelectricity for Tissue Regeneration

Advanced Science, EarlyView.
This review provides an intriguing review of the recent advancements, challenges, and future perspectives regarding the application of piezoelectric scaffolds in tissue regeneration. The detailed exposition is anticipated to propel the advancement of personalized and intelligent piezoelectric implants, thereby fostering significant progress in this ...
Xiaoling Deng, Yu Zhuang, Jinjie Cui, Liyun Wang, Huilu Zhan, Xudong Wang, Kaili Lin, Changyong Yuan   +7 more
wiley   +1 more source

Treatment of dogs with compensated myxomatous mitral valve disease with spironolactone-a pilot study [PDF]

, 2017
Spironolactone improves outcome in dogs with advanced myxomatous mitral valve disease (MMVD). Its efficacy in preclinical MMVD is unknown. The hypothesis was the administration of spironolactone to dogs with compensated MMVD demonstrating risk factors ...
Boswood, A, Elliott, J, Hezzell, M J, Lopez-Alvarez, J, Lotter, N S   +4 more
core   +3 more sources

PIEZO Force Sensing in Vascular Biology: An Explosion of New Knowledge, Concepts and Opportunity

Advanced Science, EarlyView.
Knowledge of the remarkable mechanical force sensing and electrically transducing PIEZO1 and PIEZO2 channels is discussed across vascular biology and its cell types from the embryonic to adult stages in health, disease and old age. How the channels work, relate to other factors and signal for tissue responses to mechanical forces is debated.
David J Beech
wiley   +1 more source

Jefferson Vascular Center Among the First to Implant Fenestrated Aortic Grafts [PDF]

, 2013
The Jefferson Vascular Center brings together surgical and medical specialties to provide comprehensive care to patients with vascular diseases (diseases of blood vessels) and thrombotic (blood-clotting) disorders, as well as care of complex vascular ...

core   +1 more source

Long‐Term Nutritional Benefits of Laparoscopic Pancreatoduodenectomy Over Open Surgery

Annals of Gastroenterological Surgery, EarlyView.
Minimally invasive laparoscopic pancreaticoduodenectomy (LPD) significantly improves long‐term nutritional outcomes compared to open pancreaticoduodenectomy (OPD). LPD patients demonstrated better preservation of muscle mass index (PMI) and a lower incidence of postoperative fatty liver.
Koki Kurahashi, Takayuki Anazawa, Kei Yamane, Kazuyuki Nagai, Satoshi Ishida, Satoshi Ogiso, Yoichiro Uchida, Takashi Ito, Takamichi Ishii, Etsuro Hatano   +9 more
wiley   +1 more source

Appetite suppressants and valvular heart disease - a systematic review [PDF]

, 2002
Background Although appetite suppressants have been implicated in the development of valvular heart disease, the exact level of risk is still uncertain.
AJ Burger, Angharad Pritchard-Copley, AP Fishman, BK Shively, CC Wee, CY Teramae, D Moher, DD Hensrud, EA Fisher, H Jick, H Jick, HM Connolly, JA Arnaiz, JG Jollis, JH Noseworthy, JM Gardin, K Metcalfe, MA Khan, MK Kancherla, NB Schiller, NE Lepor, NJ Weissman, NJ Weissman, NJ Weissman, RA Moore, Sheena Derry, ST Mast, TA Wadden, Yoon K Loke   +28 more
core   +2 more sources