Results 61 to 70 of about 42,729 (266)

Recent Advancements in Lung Cancer Metastasis Prevention Based on Nanostrategies

Advanced Science, EarlyView.
Metastasis is the leading cause of death in patients with lung cancer. Nanomedicine can be used to prepare efficient drug delivery systems owing to their advantages and plays an important role in the synergistic antimetastasis of lung cancer. This comprehensive review summarizes the emerging nanostrategies against lung cancer metastasis based on the ...
Fan Xu, Yao Liu, Zujun Que, Bin Luo, Yun Yang, Yan Li, Zhanxia Zhang, Jianhui Tian   +7 more
wiley   +1 more source

P21‐Activated Kinase 2 as a Novel Target for Ventricular Tachyarrhythmias Associated with Cardiac Adrenergic Stress and Hypertrophy

Advanced Science, Volume 12, Issue 17, May 8, 2025.
Ca2+/calmodulin‐dependent kinase II (CaMKII) activation is likely driven by oxidative stress, particularly excessive reactive oxygen species (ROS) production. This study identifies P21‐activated kinase 2 (Pak2) as a novel regulator of ROS‐induced CaMKII activation and abnormal Ca2⁺ dynamics in acute adrenergic and chronic pressure‐overload stressed ...
Tao Li, Ting Liu, Yan Wang, Yangpeng Li, Leiying Liu, James Bae, Yu He, Xian Luo, Zhu Liu, Tangting Chen, Xianhong Ou, Dan Zhang, Huan Lan, Juyi Wan, Yan Wei, Fang Zhao, Xin Wang, Tao Li, Christopher L.‐H. Huang, Chunxiang Zhang, Ming Lei, Xiaoqiu Tan   +21 more
wiley   +1 more source

SENP3 Drives Abdominal Aortic Aneurysm Development by Regulating Ferroptosis via De‐SUMOylation of CTH

Advanced Science, Volume 12, Issue 16, April 24, 2025.
In this study, it is proposed that SENP3 accumulates in macrophages of aneurysmal aortic tissues, which promotes macrophage ferroptosis and inflammation via regulation of CTH de‐SUMOylation. Abstract Abdominal aortic aneurysm (AAA) is a high‐risk inflammatory disorder. SENP3, a SUMO2/3‐specific protease, is closely involved in the development of cancer.
Long Chen, Zhaohua Cai, Danrui Xiao, Yiping Shi, Qingqing Xiao, Min Liang, Yangjing Jiang, Yijie Huang, Feng Liang, Guo Zhou, Fei Zhuang, Xia Wang, Huanhuan Huo, Liang Fang, Qin Shao, Ben He   +15 more
wiley   +1 more source

Simultaneous valve-in-valve procedure and life-saving coronary angioplasty in a patient with low coronary artery ostia

Advances in Interventional Cardiology, 2021
A 75-year-old woman with hypertension, diabetes mellitus type 2, permanent atrial fibrillation, and chronic kidney disease was admitted to the hospital due to exacerbation of chronic heart failure, vertigo, and syncopal events.
Michał Walczewski, Aleksandra Gąsecka, Piotr Pęczek, Michał Marchel, Bartosz Rymuza, Janusz Kochman   +5 more
doaj   +1 more source

Systolic ejection murmurs and the left ventricular outflow tract in boxer dogs [PDF]

, 2007
Turbulence of various genesis in the left ventricular outflow tract (LVOT) causes systolic ejection murmurs. The prevalence of murmurs in adult boxer dogs is 50-80%, the majority of which are of low intensity.
Höglund, Katja
core  

Interdisciplinary three-step strategy to treat aortic stenosis and coronary artery disease in a patient with end-stage chronic obstructive pulmonary disease [PDF]

, 2012
Background: Valvular aortic stenosis is a common disease in the elderly, often in multimorbid patients. It is often associated with coronary artery disease and peripheral artery disease.
Beiras Fernández, Andrés, Bigdeli, Amir K., Kaczmarek, Ingo, Michel, Sebastian, Schmitz, Christoph, Sodian, Ralf, Wolf, Manuel   +6 more
core   +2 more sources

Uncover Hidden Physical Information of Soft Matter by Observing Large Deformation

Advanced Science, EarlyView.
Detecting internal abnormalities in soft matter remains challenging due to its heterogeneous nature. This study introduces a method that infers hidden physical properties by matching observed deformation with simulation through parallel Bayesian optimization.
Huanyu Yang, Yitao Cheng, Penghui Zhao, Jiageng Cai, Zhaowei Yin, Shaomin Chen, Ge Guo, Chi Zhu, Ke Liu, Lingyun Zu   +9 more
wiley   +1 more source

Vessel‐On‐A‐Chip Coupled Proteomics Reveal Pressure‐Overload‐Induced Vascular Remodeling

Advanced Science, EarlyView.
A vessel‐on‐a‐chip system is developed to replicate both physiological and pathological vessel cyclic stretches. Proteomic analysis reveals pressure‐overload‐induced vascular remodeling, including cellular response to mechanical cues, cellular oxidative stresses, ER stress, and ceramide biosynthesis activation in the vessel‐on‐a‐chip system, well ...
Yanjun Liu, Jianxujie Zheng, Lingyan Zhong, Zengyu Wang, Dan Zhao, Hong Lin, Xiaoxue Zhang, Ke Meng, Xiaoxia Yang, Dongxue Zhang, Ling Lin, Liang Qiao   +11 more
wiley   +1 more source

ALTERNATIVE METHOD OF SURGICAL CORRECTION OF DISSECTING AORTIC ANEURYSMS WITH AORTIC INSUFFIECIENCY

Вестник трансплантологии и искусственных органов, 2009
Patients with dissecting aortic aneurysm and associated acute aortic insufficiency form a group of seriously ill patients with significant cardiac failure, generally involving other organs and systems.
M. L. Semenovsky, G. A. Akopov
doaj   +1 more source

The Influence of the Aortic Root Geometry on Flow Characteristics of a Bileaflet Mechanical Heart Valve [PDF]

arXiv, 2018
Bileaflet mechanical heart valves have one of the most successful valve designs for more than 30 years. These valves are often used for aortic valve replacement, where the geometry of the aortic root sinuses may vary due to valvular disease and affect valve performance. Common geometrical sinus changes may be due to valve stenosis and insufficiency. In
arxiv