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Noonan syndrome and related conditions are caused by variants in multiple genes. We analyzed 456 Russian patients using a 23‐gene panel and found disease‐causing variants in non‐PTPN11 genes in 85 cases. NF1, SOS1, BRAF, and SHOC2 explained half of these diagnoses.
Anna Orlova +5 more
wiley +1 more source
ABSTRACT Background Postoperative delirium is a serious complication in intensive care units (ICUs), particularly following cardiac surgery. It is associated with circadian rhythm disruption, sleep disturbances and adverse outcomes. ICU environments often lack natural time cues, which may exacerbate circadian misalignment and increase delirium risk ...
Jolana Wagner‐Skacel +18 more
wiley +1 more source
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Current Cardiology Reports, 2019
Aortic regurgitation (AR) is a common form of valvular disease which is characterized by reflux of blood from the aorta into the left ventricle (LV) during diastole. AR results from various etiologies, affecting the aortic valve cusps or the aortic root.
Nir, Flint +5 more
openaire +3 more sources
Aortic regurgitation (AR) is a common form of valvular disease which is characterized by reflux of blood from the aorta into the left ventricle (LV) during diastole. AR results from various etiologies, affecting the aortic valve cusps or the aortic root.
Nir, Flint +5 more
openaire +3 more sources
The A‐Dip of Aortic Regurgitation
Echocardiography, 2013Careful analysis of the aortic regurgitation (AR) Doppler signal often provides important information regarding left heart hemodynamics. Here we illustrate a pattern on the AR signal, known as the A‐dip that suggests the presence of elevated LVEDP.
Fadel BM +3 more
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Traumatic aortic regurgitation
The American Journal of Cardiology, 1962Abstract A patient is reported who sustained myocardial contusion with complete heart block, pericardial effusion and rupture of the aortic valve following blunt chest trauma. An attempt at direct surgical repair of the valvular lesion was unsuccessful.
R J, LEVINE, W C, ROBERTS, A G, MORROW
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The A-Dip of aortic regurgitation
Journal of the American Society of Echocardiography, 2003Echocardiography has become the diagnostic technique of choice for delineating the intracardiac hemodynamics in a host of pathophysiologic states. Pressures and flows can be estimated or measured with enough accuracy to allow for clinical decision-making. We present a case with an unusual Doppler echocardiographic finding and discuss its derivation.
Jesse S, Sethi +5 more
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Aortic Regurgitation and Pericarditis
Archives of Pediatrics & Adolescent Medicine, 1970History of Present lllness. —The patient was a 13-year-old white boy who was in good health until five weeks prior to his first admission to this hospital on June 2, 1967. At this time, he complained of a sore throat which lasted one to two days. Two and one-half weeks prior to admission he had "flu" and nine days prior to admission, his temperature ...
P R, Lurie, B G, Reed
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Aortic regurgitation in the elderly
American Heart Journal, 1966Abstract The incidence of aortic insufficiency was determined in 291 patients over the age of 65 who were admitted consecutively to the medical services of the District of Columbia General Hospital. The subjects were examined independently by three physicians for the presence of a diastolic blowing murmur. Twelve per cent of the patients had a murmur
A, Bleich, J, Lewis, F I, Marcus
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Aortic Regurgitation in the Dog
Journal of the American Veterinary Medical Association, 1976SUMMARY In a review of aortic regurgitation in 12 dogs, breed or sex predilection was not found. Clinical signs included decreased exercise tolerance and diastolic murmur. Associated anomalies included ventricular septal defect and aortic stenosis. It was concluded that when aortic regurgitation develops secondary to a ventricular septal defect, the ...
G E, Eyster, L K, Anderson, G B, Cords
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Current Treatment Options in Cardiovascular Medicine, 2000
Left ventricular (LV) systolic function is an important determinant of long-term prognosis in patients with chronic aortic regurgitation (AR). Impaired LV systolic function identifies a group of patients who are at risk of developing postoperative congestive heart failure and death after aortic valve replacement (AVR). Hence, asymptomatic patients with
openaire +2 more sources
Left ventricular (LV) systolic function is an important determinant of long-term prognosis in patients with chronic aortic regurgitation (AR). Impaired LV systolic function identifies a group of patients who are at risk of developing postoperative congestive heart failure and death after aortic valve replacement (AVR). Hence, asymptomatic patients with
openaire +2 more sources

