Atenolol versus losartan in children and young adults with Marfan's syndrome [PDF]
BACKGROUND : Aortic-root dissection is the leading cause of death in Marfan's syndrome. Studies suggest that with regard to slowing aortic-root enlargement, losartan may be more effective than beta-blockers, the current standard therapy in most centers.
Atz, A.M.+33 more
core +7 more sources
Aortic root remodeling was originally designed in the late 1980s to treat patients with tricuspid aortic valves (TAVs), aortic regurgitation (AR), and root aneurysm to normalize root dimensions. The late results showed a relevant proportion of patients who required reoperation for recurrent AR.
Giebels, Christian+2 more
openaire +2 more sources
Sarcoidosis of the aortic root [PDF]
Sarcoidosis is a clinical entity characterized by noncaseating epithelioid granulomas affecting multiple organs. The cause remains perplexing, but the available evidence points to an exaggerated cellular response as the feature of the disorder. The granulomas, composed of mononuclear phagocytes encircled by CD4 T lymphocytes, have the potential for ...
Frank J. Rybicki+6 more
openaire +3 more sources
Infective endocarditis affecting the aortic valve may be complicated by an abscess cavity in the aortic root,1-3 and this is more frequent and serious in prosthetic than native valve infections.4 5 Successful management of this condition, which has high morbidity and mortality, invariably requires surgical repair, and depends on early diagnosis, clear ...
J R Pepper, Stephen Brecker, S J Eykyn
openaire +3 more sources
Evaluation of the Appropriate Root Pressure for Maintaining Heartbeat during an Aortic Cross-clamp for Primary Repair of the Aortic Arch in Premature Infants with Associated Cardiac Anomalies [PDF]
We developed a new cardiopulmonary bypass (CPB) method to minimize myocardial damage during aortic arch reconstruction. In this method, coronary flow and heartbeat were stabilized by maintaining the aortic root pressure with an adjusted preload of the ...
Honjo, Osami+5 more
core +1 more source
Angiotensin II blockade and aortic-root dilation in Marfan's syndrome [PDF]
Background: Progressive enlargement of the aortic root, leading to dissection, is the main cause of premature death in patients with Marfan's syndrome. Recent data from mouse models of Marfan's syndrome suggest that aortic-root enlargement is caused by ...
Brooke, Benjamin S.+5 more
core +2 more sources
Quadriscupid aortic valve with concurrent aortic stenosis and insufficiency [PDF]
We present the case of a 22-year-old man with a congenital mixed aortic valve dysfunction who underwent cardiac Magnetic Resonance Imaging (MRI) for the assessment of aortic valve morphology and function prior to valve replacement.
Devos, Daniel+2 more
core +3 more sources
Aortic root conservative repair of acute type A aortic dissection involving the aortic root: Fate of the aortic root and aortic valve function [PDF]
Despite many studies about aortic valve function and aortic root geometry after conservative aortic root repair of acute type A aortic dissection, the results are not always consistent or conclusive. This study aims to evaluate aortic root diameter and aortic valve function after surgery for acute type A aortic dissection involving the aortic root.A ...
Jae Won Lee+6 more
openaire +3 more sources
Immersed boundary-finite element model of fluid-structure interaction in the aortic root [PDF]
It has long been recognized that aortic root elasticity helps to ensure efficient aortic valve closure, but our understanding of the functional importance of the elasticity and geometry of the aortic root continues to evolve as increasingly detailed in ...
A. Cheng+74 more
core +3 more sources
Isolated aortic root dilation in homocystinuria [PDF]
BACKGROUND: Vascular complications in homocystinuria have been known for many years, but there have been no reports to date on involvement of the ascending aorta.
Davison, JE+8 more
core +2 more sources