Results 1 to 10 of about 840,115 (246)

Angiotensin II Induces Aortic Rupture and Dissection in Osteoprotegerin-Deficient Mice. [PDF]

J Am Heart Assoc, 2022
Background: The biological mechanism of action for osteoprotegerin (OPG), a soluble decoy receptor for the receptor activator of nuclear factor kappa-B ligand (RANKL) in the vascular structure, has not been elucidated.
Tsuruda T, Yamashita A, Otsu M, Koide M, Nakamichi Y, Sekita-Hatakeyama Y, Hatakeyama K, Funamoto T, Chosa E, Asada Y, Udagawa N, Kato J, Kitamura K.   +12 more
europepmc   +2 more sources

mTOR inhibition prevents angiotensin II-induced aortic rupture and pseudoaneurysm but promotes dissection in Apoe-deficient mice. [PDF]

JCI Insight, 2022
Aortic dissection and rupture are triggered by decreased vascular wall strength and/or increased mechanical loads. We investigated the role of mTOR signaling in aortopathy using a well-described model of angiotensin II–induced dissection, aneurysm, or ...
He C, Jiang B, Wang M, Ren P, Murtada SI, Caulk AW, Li G, Qin L, Assi R, Lovoulos CJ, Schwartz MA, Humphrey JD, Tellides G.   +12 more
europepmc   +2 more sources

Critical Role of Cytosolic DNA and Its Sensing Adaptor STING in Aortic Degeneration, Dissection, and Rupture

Circulation, 2020
Supplemental Digital Content is available in the text. Background: Sporadic aortic aneurysm and dissection (AAD), caused by progressive aortic smooth muscle cell (SMC) loss and extracellular matrix degradation, is a highly lethal condition.
Wei Luo, Yidan Wang, Lin Zhang, Pingping Ren, Chen Zhang, Yanming Li, Alon R. Azares, Michelle S. Zhang, Jiao Guo, K. Ghaghada, Z. Starosolski, K. Rajapakshe, C. Coarfa, Yumei Li, Rui Chen, K. Fujiwara, J. Abe, J. Coselli, D. Milewicz, S. Lemaire, Ying H. Shen   +20 more
semanticscholar   +1 more source

Risk Factors and Mouse Models of Abdominal Aortic Aneurysm Rupture

International Journal of Molecular Sciences, 2020
Abdominal aortic aneurysm (AAA) rupture is an important cause of death in older adults. In clinical practice, the most established predictor of AAA rupture is maximum AAA diameter.
S. Murali Krishna, S. Morton, Jiaze Li, J. Golledge   +3 more
semanticscholar   +1 more source

Management of acute aortic dissection and thoracic aortic rupture

Journal of Intensive Care, 2018
BackgroundBoth acute aortic dissection and ruptured aortic aneurysm are leading causes of death in cardiovascular disease. These life-threatening conditions have recently been categorized as acute aortic syndrome.
T. Fukui
semanticscholar   +1 more source

Ascending aortic rupture after zone 2 endovascular repair: a multiparametric computational analysis.

European Journal of Cardio-Thoracic Surgery, 2019
A 74-year-old woman expired from ascending aortic rupture 3 months following branched zone 2 endovascular aortic repair. Multiparametric image-based computational evaluation of this case suggested that the stiffness mismatch between the endograft and the
T. V. Bakel, T. V. Bakel, N. Burris, H. Patel, C. A. Figueroa   +4 more
semanticscholar   +1 more source

Patients at Risk for Aortic Rupture Often Exposed to Fluoroquinolones during Hospitalization

Antimicrobial Agents and Chemotherapy, 2018
Several studies have indicated that fluoroquinolone use may be associated with an increased risk of aortic aneurysm or dissection (AAD). Because patients with AAD or Marfan syndrome are at increased risk for aortic rupture, we performed a retrospective ...
W. C. Frankel, B. Trautner, Andrew Spiegelman, L. Grigoryan, S. Lemaire   +4 more
semanticscholar   +1 more source

TGF-β Neutralization Enhances AngII-Induced Aortic Rupture and Aneurysm in Both Thoracic and Abdominal Regions

PLoS ONE, 2016
AngII and TGF-β interact in development of thoracic and abdominal aortic diseases, although there are many facets of this interaction that have not been clearly defined. The aim of the present study was to determine the effects of TGF-β neutralization on
Xiaofeng Chen, D. Rateri, Deborah A. Howatt, Anju Balakrishnan, Jessica J. Moorleghen, L. Cassis, A. Daugherty   +6 more
semanticscholar   +1 more source

Pathogenesis and management of abdominal aortic aneurysm

European Heart Journal, 2023
Graphical Abstract Graphical Abstract Potential medical therapies to limit abdominal aortic aneurysm growth or rupture. VSMC, vascular smooth muscle cell; LDL, low density lipoprotein.
J. Golledge, S. Thanigaimani, J. Powell, Phillip S Tsao   +3 more
semanticscholar   +1 more source

Early detection of vulnerable atherosclerotic plaque for risk reduction of acute aortic rupture and thromboemboli and atheroemboli using non-obstructive angioscopy.

Circulation Journal, 2015
The mortality rate due to rupture of aortic dissection and aortic aneurysm is approximately 90%. Acute aortic rupture can be fatal prior to hospitalization and has proven difficult to diagnose correctly or predict.
S. Komatsu, T. Ohara, S. Takahashi, M. Takewa, H. Minamiguchi, Atsuko Imai, Yasuhiko Kobayashi, N. Iwa, C. Yutani, A. Hirayama, K. Kodama   +10 more
semanticscholar   +1 more source