Results 91 to 100 of about 58,576 (312)

Inhibiting the Histone Demethylase Kdm4a Restrains Cardiac Fibrosis After Myocardial Infarction by Promoting Autophagy in Premature Senescent Fibroblasts

open access: yesAdvanced Science, EarlyView.
Kdm4a downregulation restrains excessive cardiac interstitial fibrosis and remodeling by depressing the premature senescence of fibroblasts in the advanced stage after MI but does not affect early ventricular rupture. It verified that Kdm4a downregulation promotes autophagy in premature senescent fibroblasts by increasing the H3K9m3 modification of the
Ming Jin   +15 more
wiley   +1 more source

A Markov Decision Process Model to Guide Treatment of Abdominal Aortic Aneurysms [PDF]

open access: yes, 2016
An abdominal aortic aneurysm (AAA) is an enlargement of the abdominal aorta which, if left untreated, can progressively widen and may rupture with fatal consequences. In this paper, we determine an optimal treatment policy using Markov decision process modeling.
arxiv   +1 more source

Weighted high dimensional data reduction of finite Element Features -- An Application on High Pressure of an Abdominal Aortic Aneurysm [PDF]

open access: yesarXiv, 2023
In this work we propose a low rank approximation of high fidelity finite element simulations by utilizing weights corresponding to areas of high stress levels for an abdominal aortic aneurysm, i.e. a deformed blood vessel. We focus on the van Mises stress, which corresponds to the rupture risk of the aorta.
arxiv  

Silicon Enhances Functional Mitochondrial Transfer to Improve Neurovascularization in Diabetic Bone Regeneration

open access: yesAdvanced Science, EarlyView.
These findings reveal that silicon exerts strong protective effects in diabetic bone defect models by selectively promoting Drp1‐Mff activity. Silicon facilitates precise regulation of mitochondrial dynamics to enable functional mitochondrial transfer.
Yu‐Xuan Ma   +12 more
wiley   +1 more source

Idiopathic congenital abdominal aortic aneurysm rupture treated with emergency graft replacement in a 29-day-old infant

open access: yesAnnals of Vascular Surgery - Brief Reports and Innovations, 2022
Background: Idiopathic congenital abdominal aortic aneurysms are rare. Their etiology, pathophysiology, and appropriate treatment remain unclear because only a few cases have been reported in the literature.
Yosuke Kugo   +2 more
doaj  

Delayed Surgery in a Complex Trauma Patient with Aortic Rupture, Blunt Head Trauma and Liver Laceration: a Case Report

open access: yesKaohsiung Journal of Medical Sciences, 2008
Aortic rupture is a critical condition in trauma patients. Most patients are killed at the scene of the accident. A patient who survives long enough to reach hospital also has a high risk of rupture during management.
Hsing-Lin Lin   +4 more
doaj   +1 more source

Endovascular treatment of aortic stump blow-out after extra-anatomical repair of aortoduodenal fistula: a case report and review of literature

open access: yesCVIR Endovascular, 2020
Background An aortoduodenal fistula (ADF) is an unusual, but serious complication following surgical or endovascular aortic repair. The optimal treatment for ADF consists of removal of the infected graft with in situ or extra-anatomical repair and is ...
E. Beijer   +5 more
doaj   +1 more source

TGF-β Neutralization Enhances AngII-Induced Aortic Rupture and Aneurysm in Both Thoracic and Abdominal Regions. [PDF]

open access: yesPLoS ONE, 2016
AngII and TGF-β interact in development of thoracic and abdominal aortic diseases, although there are many facets of this interaction that have not been clearly defined. The aim of the present study was to determine the effects of TGF-β neutralization on
Xiaofeng Chen   +6 more
doaj   +1 more source

Homocysteine Promotes the Pathogenesis of Atherosclerosis through the Circ‐PIAS1‐5/miR‐219a‐2‐3p/TEAD1 Axis

open access: yesAdvanced Science, EarlyView.
A model is schematically represented for the major molecular mechanisms by which homocysteine (Hcy) accelerates the nuclear export of circ‐PIAS1‐5, which regulates atherosclerosis by acting as a competing endogenous RNA for miR‐219a‐2‐3p. Hcy enrichment of circ‐PIAS1‐5 leads to YTHDC1 binding to circ‐PIAS1‐5 and promotes its intracellular localization ...
Shengchao Ma   +13 more
wiley   +1 more source

IRF8 Drives Conventional Type 1 Dendritic Cell Differentiation and CD8+ T Cell Activation to Aggravate Abdominal Aortic Aneurysm Development

open access: yesAdvanced Science, EarlyView.
This study highlights the critical role of IRF8 in the development of AAA. IRF8 activation promotes the differentiation of cDC1s, which in turn recruit and activate CD8+ T cells, contributing to aortic wall degradation. The study identifies the IRF8‐cDC1‐CD8+ T cell axis as a key pathway in AAA progression, offering new potential therapeutic targets to
Zhen Yuan   +11 more
wiley   +1 more source

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