Targeting CRM1 for Progeria Syndrome Therapy
Pharmacological inhibition of CRM1 mediated by selinexor, the first‐in‐class selective inhibitor of CRM1, mitigates the senescent phenotype of Hutchinson‐Gilford progeria syndrome (HGPS) patients‐derived primary fibroblasts. Treatment of HGPS fibroblasts with selinexor promotes the clearances of progerin via autophagy activation, restores the ...
Adriana Soto‐Ponce+14 more
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Unusual aortic rupture: What is cold can become catastrophic! [PDF]
Chandrashekhara SH, Kumar S.
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J. Brimacombe, Alison M. Berry
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Aged rats and human are more susceptible to MASLD‐related liver injury, steatosis, and fibrosis, accompanied by worsening of endothelial dysfunction. The SIRT1/p‐eNOS/NO pathway is involved in aggravated MASLD caused by aging‐related LSECs dysfunction.
Qingqing Dai+5 more
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Endovascular Treatment With a Balloon-Expandable Covered Stent in a Polytrauma 12-Year-Old Patient With Traumatic Abdominal Aortic Rupture. [PDF]
Florou M+7 more
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Adventitial remodeling protects against aortic rupture following late smooth muscle-specific disruption of TGFβ signaling. [PDF]
Kawamura Y+5 more
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Preventing Rupture of Abdominal Aortic Aneurysm by Earlier Elective Repair [PDF]
Robert C. Allen+5 more
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Regarding "Aortic rupture during STABILISE (stent-assisted balloon-induced intimal disruption and relamination in aortic dissection repair) technique". [PDF]
Faure EM.
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S-2-23 Ruptured thoracic aortic aneurysm. Treatment and review of nine patients
Junko Kumada
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