Results 301 to 310 of about 112,522 (335)

The inhibitory SAPS3–AMPK interaction detected in HEK293 cells is not detectable in muscle or liver from humans or mice

FEBS Letters, Volume 599, Issue 23, Page 3537-3544, December 2025.
This study challenges the idea that Sit4‐associated protein subunit 3 (SAPS3) inhibits the energy‐sensing enzyme AMP‐activated protein kinase (AMPK) in muscle and liver tissue. Although SAPS3 interacts with AMPK in cultured cells, we found no such interaction in human or mouse tissues subjected to fasting, exercise, or a high‐fat diet.
Jesper B. Birk, Maria A. Møller, Jørgen F.P. Wojtaszewski, Rasmus Kjøbsted   +3 more
wiley   +1 more source

Understanding Cardiovascular Events With JAK Inhibitors: Similarities and Differences of the Vascular Effects Between Different JAK Inhibitors on Endothelial Cells Exposed to Inflammatory Cytokines

ACR Open Rheumatology, Volume 7, Issue 12, December 2025.
Objective A cardiovascular safety issue has been associated with JAK inhibitors (JAKi). This study compares the effects of distinct approved JAKi on endothelial cell (EC) dysfunction and apoptosis during inflammation. Methods Massive inflammation was induced in human vascular ECs by tumor necrosis factor (TNF) with interleukin‐17A (IL‐17A) treated or ...
Aliki Zavoriti, Pierre Miossec
wiley   +1 more source

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Aortic Rupture in Transcatheter Aortic Valve Replacement

Journal of Invasive Cardiology, 2021
This case demonstrates a rare but catastrophic complication of transcatheter aortic valve replacement (TAVR). In an era where TAVR is now indicated in low-risk patients, serious complication rates are less frequent. It exemplifies the importance of preparedness for vascular injury, with readiness for vascular covered stenting and potential bail-out ...
David, Blusztein, Harsh, Agrawal
openaire   +2 more sources

RUPTURE OF THE AORTIC VALVE

Journal of the American Medical Association, 1952
When a healthy person during vigorous exercise or straining has a sudden cough and a sense of suffocation or pain in the chest with severe congestive heart failure following, the largely unsolved problem of just why heart failure occurs when it does is highlighted.
W B, BEAN, F X, MOHAUPT
openaire   +2 more sources

Aortic rupture in the Turkey

Journal of Atherosclerosis Research, 1961
Summary The histo-pathological appearances of dissecting aneurysm in broad breasted bronze turkeys are described. An intimai plaque found at the site of rupture contained lipid in the region of the internal elastic lamina and it is suggested that this may be the primary lesion. The possible relationship of this lesion to diet is discussed.
G A, GRESHAM, A N, HOWARD
openaire   +2 more sources

Traumatic Aortic Rupture

JAMA: The Journal of the American Medical Association, 1974
Diagnosis: Traumatic aortic rupture. The chest roentgenogram on admission (Fig 1) shows enlargement of the aortic knob, widened mediastinum, and density along the descending aorta. There is a small pneumothorax on the right and bilateral juxtahilar alveolar infiltration characteristic of pulmonary contusion.
openaire   +2 more sources

Rupture of the Aortic Valve

New England Journal of Medicine, 1955
RUPTURE of the aortic valve may occur as a result of trauma,1 2 3 4 strain,1 , 5 or bacterial infection.6 , 7 The valves are usually the site of some predisposing factors such as rheumatic valvulit...
J J, LEONARD, W P, HARVEY, C A, HUFNAGEL
openaire   +2 more sources

Management of traumatic aortic rupture

Surgery Today, 2013
A traumatic thoracic aortic injury is a severe and life-threatening clinical entity. Although largely fatal; if untreated, these injuries are amenable to surgical repair if appropriately diagnosed. Therefore, early triage of this condition is critically important.
Ken-ichi, Watanabe, Ikuo, Fukuda, Yasushi, Asari   +2 more
openaire   +2 more sources

Ruptured mycotic aortic aneurysm

Urology, 1976
A right flank mass, in a patient with fever of unknown origin, pain, and superiorly displaced right kidney on excretory urogram, was explored through a subcostal incision. Finding of a retroperitoneal abscess was anticipated; instead of a ruptured mycotic aortic aneurysm was encountered.
E R, Katz, C M, Lynne, V A, Politano
openaire   +2 more sources