Results 61 to 70 of about 867,204 (374)

The mechanism and therapy of aortic aneurysms

Signal Transduction and Targeted Therapy, 2023
Aortic aneurysm is a chronic aortic disease affected by many factors. Although it is generally asymptomatic, it poses a significant threat to human life due to a high risk of rupture.
Jianing Gao, Huanhuan Cao, Gaofei Hu, Yufei Wu, Yangkai Xu, Hongtu Cui, Hong S. Lu, Lemin Zheng   +7 more
semanticscholar   +1 more source

Reduced Necrosis and Content of Apoptotic M1 Macrophages in Advanced Atherosclerotic Plaques of Mice With Macrophage-Specific Loss of Trpc3 [PDF]

, 2017
In previous work we reported that ApoeKO mice transplanted with bone marrow cells deficient in the Transient Receptor Potential Canonical 3 (TRPC3) channel have reduced necrosis and number of apoptotic macrophages in advanced atherosclerotic plaques ...
Birnbaumer, Lutz, Dube, Prabhatchandra R., Solanki, Sumeet, Vazquez, Guillermo   +3 more
core   +1 more source

Predictive imaging for thoracic aortic dissection and rupture: moving beyond diameters

European Radiology, 2019
Acute aortic syndromes comprise a group of potentially fatal conditions that result from weakening of the aortic vessel wall. Pre-emptive surgical intervention is currently reserved for patients with severe aortic dilatation, although abundant evidence ...
B. Adriaans, J. Wildberger, J. Westenberg, H. Lamb, S. Schalla   +4 more
semanticscholar   +1 more source

Effect of Ciprofloxacin on Susceptibility to Aortic Dissection and Rupture in Mice

JAMA Surgery, 2018
Importance Fluoroquinolones are among the most commonly prescribed antibiotics. Recent clinical studies indicated an association between fluoroquinolone use and increased risk of aortic aneurysm and dissection (AAD).
S. Lemaire, Lin Zhang, Wei Luo, Pingping Ren, Alon R. Azares, Yidan Wang, Chen Zhang, J. Coselli, Ying H. Shen   +8 more
semanticscholar   +1 more source

Pathogenesis and management of abdominal aortic aneurysm

European Heart Journal, 2023
Graphical Abstract Graphical Abstract Potential medical therapies to limit abdominal aortic aneurysm growth or rupture. VSMC, vascular smooth muscle cell; LDL, low density lipoprotein.
J. Golledge, S. Thanigaimani, J. Powell, Phillip S Tsao   +3 more
semanticscholar   +1 more source

Hyperhomocysteinemia induced by excessive methionine intake promotes rupture of cerebral aneurysms in ovariectomized rats. [PDF]

, 2016
BackgroundHyperhomocysteinemia (HHcy) is associated with inflammation and a rise in the expression of matrix metalloproteinase-9 (MMP-9) in the vascular wall.
Hashimoto, Tomoki, Kanematsu, Yasuhisa, Kitazato, Keiko T, Korai, Masaaki, Matsushita, Nobuhisa, Miyamoto, Takeshi, Nagahiro, Shinji, Satomi, Junichiro, Shimada, Kenji, Tada, Yoshiteru   +9 more
core   +2 more sources

Statins Reduce Abdominal Aortic Aneurysm Growth, Rupture, and Perioperative Mortality: A Systematic Review and Meta‐Analysis

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2018
Background There are no recognized pharmacological treatments for abdominal aortic aneurysms (AAA), although statins are suggested to be beneficial. We sought to summarize the literature regarding the effects of statins on human AAA growth, rupture, and ...
K. Salata, M. Syed, M. Hussain, C. de Mestral, E. Greco, M. Mamdani, J. Tu, T. Forbes, Deepak L. Bhatt, S. Verma, M. Al-Omran   +10 more
semanticscholar   +1 more source

ADAMTS4-specific MR probe to assess aortic aneurysms in vivo using synthetic peptide libraries

Nature Communications, 2022
New biomarkers are required to improve the assessment of aortic wall integrity and risk of rupture. Here the authors report the development of an imaging probe for ADAMTS4, which they test in an abdominal aortic aneurysm mouse model and show in vivo ...
Jan O. Kaufmann, Julia Brangsch, Avan Kader, Jessica Saatz, Dilyana B. Mangarova, Martin Zacharias, Wolfgang E. Kempf, Timm Schwaar, Marco Ponader, Lisa C. Adams, Jana Möckel, Rene M. Botnar, Matthias Taupitz, Lars Mägdefessel, Heike Traub, Bernd Hamm, Michael G. Weller, Marcus R. Makowski   +17 more
doaj   +1 more source

Detection of aortic rupture using post-mortem computed tomography and post-mortem computed tomography angiography by cardiac puncture

Zeitschrift für Rechtsmedizin, 2015
Post-mortem computed tomography (PMCT) and post-mortem computed tomography angiography (PMCTA) are rapidly becoming effective and practical methods in forensic medicine.
Shu Zhou, L. Wan, Y. Shao, Chong-liang Ying, Ya-hui Wang, D. Zou, Wentao Xia, Yijiu Chen   +7 more
semanticscholar   +1 more source

Modelling Atherosclerotic Plaque Cap Mechanics: Microcalcifications Reduce Mechanical Properties in Mesenchymal Stromal Cell‐Based Model

Advanced Biology, EarlyView.
This study develops a tissue‐engineered model of the atherosclerotic cap using human mesenchymal stromal cells (MSCs). After 2 weeks of culture to produce a collagenous matrix, a mineralizing medium induces microcalcifications over 4 weeks. These constructs, imaged with second harmonic generation microscopy, lead to reduced ultimate stress at rupture ...
Imke L. Jansen, Deniz Şahin, Frank J.H. Gijsen, Eric Farrell, Kim van der Heiden   +4 more
wiley   +1 more source