Results 81 to 90 of about 847,575 (400)

Numerical simulation of flows in a circular pipe transversely subjected to a localized impulsive body force with applications to blunt traumatic aortic rupture [PDF]

Fluid Dynamics Research, 49(3), 035510 (2017), 2018
Much debate surrounds the mechanisms responsible for the occurrence of blunt traumatic aortic rupture in car accidents, particularly on the role of the inertial body force experienced by the blood due to the abrupt deceleration. The isolated influence of such body forces acting on even simple fluid flows is a fundamental problem in fluid dynamics that ...
arxiv   +1 more source

The mechanism and therapy of aortic aneurysms

Signal Transduction and Targeted Therapy, 2023
Aortic aneurysm is a chronic aortic disease affected by many factors. Although it is generally asymptomatic, it poses a significant threat to human life due to a high risk of rupture.
Jianing Gao, Huanhuan Cao, Gaofei Hu, Yufei Wu, Yangkai Xu, Hongtu Cui, Hong S. Lu, Lemin Zheng   +7 more
semanticscholar   +1 more source

A Comparison of the Mechanical Properties of ECM Components and Synthetic Self‐Assembling Peptides

Advanced Healthcare Materials, EarlyView.
Self‐assembling peptide hydrogels are increasingly utilized in biomedical applications. The authors review the key mechanical properties of these structures across multiple size scales and compare them to that of native extracellular matrix components, which are found to display a much wider range of structural attributes.
Alex Hartley, Philip Michael Williams, Alvaro Mata   +2 more
wiley   +1 more source

Isolated aneurysmal disease as an underestimated finding in individuals with JAG1 pathogenic variants

Human Mutation, Volume 43, Issue 12, Page 1824-1828, December 2022., 2022
Abstract Pathogenic variants in JAG1 are known to cause Alagille syndrome (ALGS), a disorder that primarily affects the liver, lung, kidney, and skeleton. Whereas cardiac symptoms are also frequently observed in ALGS, thoracic aortic aneurysms have only been reported sporadically in postmortem autopsies.
Jotte Rodrigues Bento, Alice Krebsová, Ilse Van Gucht, Irene Valdivia Callejon, An Van Berendoncks, Pavel Votypka, Ilse Luyckx, Petra Peldova, Steven Laga, Marek Havelka, Lut Van Laer, Pavel Trunecka, Nele Boeckx, Aline Verstraeten, Milan Macek, Josephina A. N. Meester, Bart Loeys   +16 more
wiley   +1 more source

Traumatic rupture of the aorta : a case report and discussion of clinical features [PDF]

, 2012
A young female patient was involved in a head-on collision and sustained a rupture of the aortic isthmus. She underwent emergency surgical repair of an aortic pseudo-aneurysm with an interposition graft.
Casha, Aaron, Manche, Alexander, Tomic, Vladimir, Zerafa, Mario   +3 more
core  

Aggressive Surveillance Is Needed to Detect Endoleaks and Junctional Separation between Device Components after Zenith Fenestrated Aortic Reconstruction [PDF]

, 2019
Background Junctional separation and resulting type IIIa endoleak is a well-known problem after EVAR (endovascular aneurysm repair). This complication results in sac pressurization, enlargement, and eventual rupture.
Dalsing, Michael C., Fajardo, Andres, Gupta, Alok K., Lemmon, Gary W., Motaganahalli, Raghu L., Murphy, Michael P., Sawchuk, Alan P., Wang, S. Keisin   +7 more
core   +1 more source

“Therapies Through Gut:” Targeted Drug Delivery for Non‐Gastrointestinal Diseases by Oral Administration

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray, Shehzahdi S. Moonshi, Hang Thu Ta   +2 more
wiley   +1 more source

Identification of aortic injury site using postmortem non–contrast computed tomography in road traffic accident

Radiology Case Reports, 2021
In high-speed motor vehicle accidents, it is necessary to investigate the manner of death. Postmortem computed tomography (PMCT) provides important information on the mechanism of death, but identification of the aortic injury is still challenging on non–
Keiichi Horie, MD, Yoko Ihama, MD, PhD, Shinjiro Aso, MD, Hikaru Kuninaka, MD, Hidekazu Mochizuki, RT, Tsuneo Yamashiro, MD, PhD, Shingo Kato, MD, PhD, Daisuke Utsunomiya, MD, PhD   +7 more
doaj  

Surgical Repair of a Transannular Rupture During Transfemoral Transcatheter Aortic Valve Replacement

Clinical Medicine Insights: Case Reports, 2021
Annular rupture is a rare but life-threatening complication of transcatheter aortic valve replacement (TAVR). Mortality rates are high if immediate intervention, most often necessitating surgical repair, is not performed.
Ryaan EL-Andari, Sabin J Bozso, Jimmy JH Kang, Vinod K Manikala, Michael C Moon, Mohammed Al-Aklabi, Robert C Welsh, Jeevan Nagendran   +7 more
doaj   +1 more source

Neural operator learning of heterogeneous mechanobiological insults contributing to aortic aneurysms [PDF]

arXiv, 2022
Thoracic aortic aneurysm (TAA) is a localized dilatation of the aorta resulting from compromised wall composition, structure, and function, which can lead to life-threatening dissection or rupture. Several genetic mutations and predisposing factors that contribute to TAA have been studied in mouse models to characterize specific changes in aortic ...
arxiv