Results 161 to 170 of about 41,911 (295)

Caffeine increases aortic stiffness in hypertensive patients

open access: yes, 2003
Background: Caffeine is the most widely used pharmacologic substance. Aortic stiffness is an important factor for cardiovascular system performance and a prognosticator of cardiovascular risk. We investigated the effect of caffeine on aortic stiffness in
Stefanadis, C   +4 more
core  

Chd4 and ThPOK cooperate to preserve structural and electrophysiological integrity of the adult heart through Sprr1a repression

open access: yesThe FEBS Journal, EarlyView.
Chd4/NuRD and ThPOK cooperate to maintain transcriptional repression and nuclear organization in adult cardiomyocytes. Chd4 loss reduces miR‐150‐5p, relieving repression of Sprr1a, while ThPOK loss further enhances Sprr1a activation, possibly through altered chromatin–lamina interactions.
Fadoua El Abdellaoui‐Soussi   +12 more
wiley   +1 more source

When proteases reshape barriers: Basement membrane remodelling in development, wound healing and tumour progression

open access: yesThe FEBS Journal, EarlyView.
Basement membrane (BM) homeostasis relies on a balance between integrity, controlled remodelling and pathological degradation. Increased protease expression beneath the BM, along with reduced levels of endogenous protease inhibitors, drives the transition from a continuous, protective barrier to a discontinuous interface.
Clara Legendre   +2 more
wiley   +1 more source

Tenapanor Beyond Phosphate: Gut Sodium Transport, Stool Transit Time, and Volume Balance in Dialysis Patients

open access: yesHemodialysis International, EarlyView.
ABSTRACT Introduction Tenapanor, a minimally absorbed intestinal NHE3 inhibitor approved for hyperphosphatemia in dialysis, lowers phosphate and reduces intestinal sodium absorption. Its sodium–water signal may have implications beyond phosphate but remains poorly separated from diarrhea‐mediated losses and dialysis prescription artifacts. Methods This
Lucas Maciel de Almeida Corrêa   +8 more
wiley   +1 more source

Soft tissue abnormalities in the congenital limb malformation radial dysplasia (RD): Their clinical impact and treatment significance

open access: yesJournal of Anatomy, EarlyView.
We review the characteristic changes to the limb soft tissue and neurovascular abnormalities that have been described in the congenital limb birth defect, Radial Dysplasia. These include consistent changes in muscle anatomy or absence of specific muscles, persistent median arteries and absent radial arteries and consistent alterations in neural ...
Marco Correia Duarte   +6 more
wiley   +1 more source

Die arterielle Steifigkeit wird bei Hämodialyse-Patienten von oxidativem Stress, Inflammation und Calcium-Phosphat Metabolismus beeinflusst

open access: yes, 2008
Die progressive Einschränkung der Nierenfunktion führt zu einer vermehrten Versteifung der Gefäße (Arteriosklerose), unabhängig von und zusätzlich zur Atherosklerose, die eine erhöhte kardiovaskuläre Komplikationsrate zur Folge haben kann.
Murgan, Ilina
core  

The Anterolateral Transpedicular Transverse Process Screw Technique: Surgical Techniques, Biomechanical study and Preliminary Outcomes

open access: yesOrthopaedic Surgery, EarlyView.
This study designed a novel anterolateral screw placement technique and, based on this, developed a new anterolateral fixation method. Imaging, biomechanical, and short‐term efficacy analyses revealed that the Anterolateral Transpedicular Transverse Process Screw (ALTTS) technique achieves a high success rate for L5 vertebral fixation (pedicle width ...
Mingdong Zhang   +6 more
wiley   +1 more source

Beneficial Effect of Vardenafil on Aortic Stiffness and Wave Reflections

open access: yes, 2012
Although vardenafil is widely prescribed for erectile dysfunction (ED), its effect on arterial function is not defined. Aortic stiffness, aortic pressures, and wave reflections are predictors of cardiovascular risk.
Aggelis, Athanasios   +8 more
core  

Far‐infrared irradiation attenuates platelet‐derived growth factor‐stimulated vascular smooth muscle cell migration through protein phosphatase 2A‐mediated Akt inhibition

open access: yesPhotochemistry and Photobiology, EarlyView.
FIR irradiation enhances the physical association between Akt and PP2Ac in VSMCs, independent of the hyperthermal effect of FIR rays. The increased binding between Akt and PP2Ac induced by FIR irradiation facilitates the dephosphorylation of Akt at Ser473.
Na‐Young Lee   +5 more
wiley   +1 more source

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