Results 51 to 60 of about 5,255,725 (300)

Disruption of Notch1 and Gata5 in Mice Leads to Congenital Aortic Valve Disease

JACC: Basic to Translational Science
Summary: Here, we describe Notch1;Gata5 compound mutant mice as a novel mouse model of highly penetrant congenital aortic valve disease displaying bicuspid aortic valve and progressive aortic valve stenosis.
Jun Yasuhara, MD, PhD, Mona Aljuhani, PhD, Talita Z. Choudhury, PhD, Anupama Rao, PhD, Sara Conroy, PhD, Yukie Ueyama, DVM, Stephanie LaHaye, PhD, Karlee Schultz, MS, Emily M. Cameron, MS, Sathiya N. Manivannan, PhD, Uddalak Majumdar, PhD, Vidu Garg, MD   +11 more
doaj   +1 more source

Harnessing Large‐Scale Multi‐Omics Data for Risk Prediction and Deep Phenotyping of Valvular Heart Diseases in the General Population

Advanced Science, EarlyView.
Large‐scale UK Biobank analyses identify clinical and proteomic signatures for early prediction of valvular heart disease and its subtypes. Proteins add predictive value for VHD, AVS, and MVR, with outcome‐specific compact panels showing translational potential. Multi‐layer evidence highlights matrix remodeling, protease regulation, immune inflammation,
Zhihao Jiang, Yang Liu, Mingyu Song, Ning Chen, Canqing Yu, Jun Lv, Eric Yuk Fai Wan, Lu Qi, Liming Li, Dianjianyi Sun, Bang Zheng   +10 more
wiley   +1 more source

Gene expression profiling of human calcific aortic valve disease

Genomics Data, 2016
Calcific aortic valve disease is a slowly progressive disorder that ranges from mild valve thickening (i.e. aortic sclerosis) to severe calcification of valves (i.e. aortic stenosis).
Jaana Rysä
doaj   +1 more source

A Dual‐Modal Wearable PPG Smartwatch with AI‐Enhanced Correction for High‐Accuracy and Continuous AF Burden Assessment

Advanced Science, EarlyView.
ABSTRACT Atrial fibrillation (AF) increases the risk of stroke and heart failure, yet accurate quantification of AF burden in daily life remains difficult. Although smartwatch photoplethysmography (PPG) supports continuous monitoring, complex rhythms and signal noise can impair burden estimation.
Song Zuo, Jinglei Wang, Xin Wang, Han Feng, Yize Zhao, Fadong Li, Shaobin Wei, Le Zhou, Zixu Zhao, Songjie Chen, Xiangyi Kong, Jue Wang, Liu He, Shijun Xia, Xin Li, Junmeng Zhang, Xiaoxia Liu, Xueyuan Guo, Ning Zhou, Songnan Li, Chenxi Jiang, Ribo Tang, Caihua Sang, Deyong Long, Xin Du, Jianzeng Dong, Wenwu Zhu, Changsheng Ma   +27 more
wiley   +1 more source

Palmdelphin Deficiency Evokes NF-κB Signaling in Valvular Endothelial Cells and Aggravates Aortic Valvular Remodeling

JACC: Basic to Translational Science, 2023
Summary: Palmd-deficient mice of advanced age manifest increased aortic valve peak velocity, thickened aortic valve leaflets, and excessive extracellular matrix deposition, which are key features of calcific aortic valve disease.
Yingchun Han, PhD, Jichao Zhang, MD, Zhao Yang, MD, Wen Jian, MD, Yuexin Zhu, PhD, Shijuan Gao, PhD, Yan Liu, PhD, Yingkai Li, MD, Songyuan He, MD, Congcong Zhang, MD, Yang Li, PhD, Bin You, MD, Jinghua Liu, MD, Jie Du, MD   +13 more
doaj   +1 more source

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

Advanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang, Jieyu Cui, Chunlu Huang, Wanyi Guo, Tong Liu, Yi Zhu, Shuai Shao, Kangyin Chen, Jinlong He, Qiankun Bao   +9 more
wiley   +1 more source

Clinical efficacy and safety of Cox-maze IV procedure for atrial fibrillation in patients with aortic valve calcification

Frontiers in Cardiovascular Medicine, 2023
ObjectiveAtrial fibrillation is associated with a high incidence of heart valve disease. There are few prospective clinical research comparing aortic valve replacement with and without surgical ablation for safety and effectiveness.
Ruikang Guo, Chengming Fan, Zhishan Sun, Hao Zhang, Yaqin Sun, Long Song, Zenan Jiang, Liming Liu   +7 more
doaj   +1 more source

Increased Disarray of Extracellular Matrix Collagen‐I Fiber Network and Compromised Biomechanics in Aortae From Marfan‐Syndrome Mice Assessed Through Combined Opto‐Biomechatronics

Advanced Science, EarlyView.
Combined structure‐function assessment in aortic rings from Marfan mice using MechaMorph Opto‐Biomechatronics technology relates increased elasticity (stiffness) and dynamic viscosity and less ordered extracellular matrix 3D‐structure (collagen) as potential causes for impaired Windkessel function and compromised haemodynamics in Marfan's syndrome ...
Dominik Schneidereit, Anika Nagel, Vanessa I. T. Zwaans, Laureen Schurr, Jonas Ahr, Michael Haug, Anna Piluso, Alexandra Sporkova, Matthias Karck, Andreas H. Wagner, Oliver Friedrich   +10 more
wiley   +1 more source

Concomitant transcarotid artery revascularization and transcatheter aortic valve replacement

Journal of Vascular Surgery Cases and Innovative Techniques, 2020
Concomitant carotid artery disease and aortic valve disease is common. Whereas carotid stenosis does not appear to have an effect on outcomes of patients undergoing aortic valve replacement, the management of a patient with symptomatic carotid disease ...
Peter J. Rossi, MD, FACS, FSVS, Jacob C. Wood, MD, Jeffrey Jim, MD, FACS, FSVS   +2 more
doaj   +1 more source

Cutting-Edge Regenerative Medicine Technologies for the Treatment of Heart Valve Calcification (Chapter 9) [PDF]

, 2013
http://Laura Iop and Gino Gerosa (2013). Cutting-Edge Regenerative Medicine Technologies for the Treatment of Heart Valve Calcification, Calcific Aortic Valve Disease, Dr. Elena Aikawa (Ed.), ISBN: 978-953-51-1150-4, InTech, DOI: 10.5772/55327. Available
Laura Iop, Gino Geros, IOP, LAURA, GEROSA, GINO   +3 more
core   +1 more source