Results 131 to 140 of about 41,091 (288)

Bicuspid aortic valve surgery with proactive ascending aorta repair

, 2011
ObjectivesBicuspid aortic valves are associated with aortic catastrophes, particularly dissection. We examined whether proactive repair of associated dilatation would reduce risk of subsequent aortic dissection or reoperation and whether more aggressive ...
Rajeswaran, Jeevanantham, Svensson, Lars G., Brian P. Griffin, Bruce W. Lytle, Lytle, Bruce W., Stewart, William J., William J. Stewart, Lars G. Svensson, Hammer, Donald F., Richard Grimm, Jeevanantham Rajeswaran, Donald F. Hammer, A. Marc Gillinov, Griffin, Brian P., Grimm, Richard, Eugene H. Blackstone, Kim, Kyung-Hwan, Kyung-Hwan Kim, Blackstone, Eugene H., Tomislav Mihaljevic, Gillinov, A. Marc, Mihaljevic, Tomislav   +21 more
core   +1 more source

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health

The FEBS Journal, EarlyView.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin, Sumit Bhutada, Suneel S. Apte   +2 more
wiley   +1 more source

ADAM17 and its proteolytic targets in disease pathogenesis

The FEBS Journal, EarlyView.
ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley   +1 more source

Aortic valve and aortic arch pathology after coarctation repair [PDF]

, 2003
OBJECTIVE: To investigate the incidence of clinical problems related to a bicuspid valve (aortic stenosis and regurgitation) and the incidence of ascending aorta and aortic arch pathology in combination with coarctation repair.
Roos - Hesselink, Jolien, Spitaels, SEC (Silja), Simoons, Maarten, Bogers, Ad; id_orcid, Heijdra, R.J., Simoons, M.L. (Maarten), Boersma, H. (Eric), Meijboom, F.J. (Folkert), Schölzel, BE, Meijboom, FJ (Folkert), Spitaels, S.E.C. (Silja), Boersma, Eric, Bogers, Ad, Roos-Hesselink, J.W. (Jolien), Scholzel, B.E., Bogers, A.J.J.C. (Ad), Heijdra, RJ   +16 more
core  

Chd4 and ThPOK cooperate to preserve structural and electrophysiological integrity of the adult heart through Sprr1a repression

The FEBS Journal, EarlyView.
Chd4/NuRD and ThPOK cooperate to maintain transcriptional repression and nuclear organization in adult cardiomyocytes. Chd4 loss reduces miR‐150‐5p, relieving repression of Sprr1a, while ThPOK loss further enhances Sprr1a activation, possibly through altered chromatin–lamina interactions.
Fadoua El Abdellaoui‐Soussi, Apolonia Novillo, Rocío Brea, Marta Ysbert, Lorena Cussó, Gonzalo Pizarro‐Sánchez, Manuel Desco, Iván Hernández, Ángel Luis Armesilla, Ignacio Pérez de Castro, Alicia R. Folgueras, Juan Miguel Redondo, Pablo Gómez‐del Arco   +12 more
wiley   +1 more source

Choosing aortic valve plasty for aortic root/ascending aorta repair

, 2016
Aim: The study was designed to evaluate the outcomes of aortic valve reimplantation (David procedure), as well as various techniques of aortic root reconstruction.Methods: The results of 84 valve-sparing operations for thoracic aortic aneurysms and ...
Г. И. Салагаев, Ю. В. Белов, А. А. Скворцов, П. Н. Шведов, Э. Р. Чарчян   +4 more
core   +1 more source

Left Bundle Branch Area Pacing versus Deep Septal Pacing in Patients After Transcatheter Aortic Valve Replacement

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Background Left bundle branch area pacing (LBBAP) has been reported to improve long‐term clinical outcomes in patients requiring permanent pacemaker implantation (PPMI) after transcatheter aortic valve replacement (TAVR). Deep septal pacing (DSP) has emerged as a potential alternative to LBBAP.
Liangzhen Qu, Xueting Duan, Han Chen
wiley   +1 more source

Aortic Valve Leaflet Perforation after Mitral Valve Repair

, 2012
: A 32-year-old patient with symptomatic severe aortic regurge, 6 weeks after mitral valve repair, was admitted for aortic valve surgery. No preoperative clinical data consistent with infective endocarditis could be detected.
Aboelnasr M, M. Aboelnasr, Rohn V, Vilém Rohn   +3 more
core   +1 more source

Electrophysiologic Assessment of the Successful Left Bundle Branch Pacing Using the Standardized Criteria

Journal of Cardiovascular Electrophysiology, EarlyView.
The left bundle branch anatomy graphic was created using AI‐assisted medical illustration. ABSTRACT Introduction Left bundle branch area pacing (LBBAP) is an emerging physiological pacing method that preserves ventricular synchrony. Achieving true LBB capture remains challenging, and the reported success rates vary considerably due to nonuniform ...
Nitchanun Jinpisoot, Tippawan Liabsuetrakul, Sunti Limumpornpetch, Watchara Lohawijarn, Treechada Wisaratapong   +4 more
wiley   +1 more source

Giants in the cold: Morphological evidence for vascular heat retention in the viscera but not the skeletal muscle of the basking shark (Cetorhinus maximus)

Journal of Fish Biology, EarlyView.
Abstract Fewer than 50 of the over 30,000 extant species of fishes have developed anatomical specializations facilitating endothermy in specific body regions. The plankton‐feeding basking shark (Cetorhinus maximus), traditionally classified as an ectotherm, was recently shown to have regionally endothermic traits such as centralized red muscle (RM ...
C. Antonia Klöcker, Axel Schlindwein, Martin C. Arostegui, Ingrid M. Bruvold, Joel V. Wernström, Montserrat Martin‐Armas, David W. Sims, Nicolas Straube, Andreas Altenburger, Claudia Junge   +9 more
wiley   +1 more source