Results 291 to 300 of about 141,910 (361)

OpenAI's ‘Deep Research’ for the Generation of Comprehensive Referenced Medical Text: Uses and Cautions

open access: yes
ANZ Journal of Surgery, EarlyView.
Daniel Jesudason   +4 more
wiley   +1 more source

Gaucher disease, state of the art and perspectives

open access: yesJournal of Internal Medicine, EarlyView.
Abstract Knowledge about Gaucher disease (GD), considered a model for rare diseases, has considerably increased since its discovery. The pathophysiology of this lysosomal disorder is better known, and specific therapies that can control many aspects of the disease have been developed, particularly for the most common form, Type 1 GD.
Fabrice Camou, Marc G. Berger
wiley   +1 more source

Pannexin 1 and pannexin 3 differentially regulate the cancer cell properties of cutaneous squamous cell carcinoma

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend PANX1 and PANX3 show opposite expression patterns in patient‐derived normal skin and cutaneous squamous cell carcinoma (cSCC) tumours, with PANX1 increased and PANX3 mRNA decreased in cSCC tumours compared to skin. Within the tumour PANX1 localizes to all regions, including tumour nests which house cSCC cancer cells and tumour ...
Brooke L. O'Donnell   +11 more
wiley   +1 more source

Elucidating the cellular determinants of the end‐systolic pressure‐volume relationship of the heart via computational modelling

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Using a multiscale computational model of left ventricular electromechanics, we investigated how sarcomere dynamics influence the end‐systolic pressure‐volume (ESPV) relationship in ejecting beats compared to isovolumetric beats.
Francesco Regazzoni   +2 more
wiley   +1 more source

Acute intermittent hypercapnic hypoxia augments left ventricular contractility

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Twenty‐four healthy adults were studied to determine the effects of an acute session of 40 min of intermittent hypercapnic hypoxia on cardiac performance. Cardiac function was assessed via echocardiography at rest and during graded stages of lower‐body negative pressure before and after the intervention to quantify load ...
Scott F. Thrall   +8 more
wiley   +1 more source

Cardiovascular outcome in 12‐month‐old male and female offspring of metformin‐treated obese mice

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend This study described the effects of exposure to maternal obesogenic diet and metformin treatment during pregnancy on offspring cardiovascular outcomes. Maternal diet‐induced obesity and glucose intolerance led to predominantly vascular and cardiac abnormalities in 12‐month‐old female and male offspring, respectively.
Josca M. Schoonejans   +10 more
wiley   +1 more source

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