Results 81 to 90 of about 298,673 (357)

Impact of the indexed effective orifice area on mid-term cardiac-related mortality after aortic valve replacement [PDF]

, 2010
Background There has been ongoing controversy as to whether prosthesis-patient mismatch (PPM, defined as indexed effective orifice area (EOAI)
Akdere, Deniz, Ali, Ayyaz, Bleiziffer, Sabine, Boehm, Johannes, Eichinger, Walter, Hettich, Ina M., Lange, Ruediger, Laubender, Rüdiger P., Ruzicka, Daniel   +8 more
core   +1 more source

F‐Box and Leucine‐Rich Repeat Protein 4 (FBXL4) Maintains Sarcomere Integrity and Cardiac Function by Enhancing K48‐Linked Ubiquitinated Degradation of Profilin‐1 (PFN1)

Advanced Science, EarlyView.
Schematic diagram depicting the proposed signaling mechanisms underlying the effects of FBXL4 in the setting of cardiac hypertrophy. Under hypertrophic stimulation, cardiomyocytes‐specific overexpression FBXL4 maintains sarcomere integrity and cardiac function by enhancing K48‐linked ubiquitinated degradation of PFN1 at the K70 site.
Xingda Li, Xueqi He, Xinyuan Hao, Yu Zhang, Xin Zhao, Shuang Wang, Zhenru Wang, Haonan Du, Hongda Li, Lian Yi, Zhimin Du, Weijie Du   +11 more
wiley   +1 more source

Single‐Cell Mitochondrial Lineage Tracing Decodes Fate Decision and Spatial Clonal Architecture in Human Hematopoietic Organoids

Advanced Science, EarlyView.
This study repurposes mitochondrial DNA mutations as endogenous barcodes for lineage tracing in human pluripotent stem cell‐derived organoids. Integrated with transcriptomic and spatial data, it reveals NOTCH‐mediated stromal‐progenitor crosstalk orchestrates clonal dynamics and spatial zonation during early hematopoietic development, offering a non ...
Yan Xue, Junhao Su, Yiming Chao, Lu Liu, Xinyi Lin, Yang Xiang, Mun Kay Ho, Zezhuo Su, Junyi Chen, Zhuojuan Luo, Chengqi Lin, Ruibang Luo, Theo Aurich, Jianfeng Wu, Kelvin Sin Chi Cheung, Yuanhua Huang, Joshua W. K. Ho, Ryohichi Sugimura   +17 more
wiley   +1 more source

Ten-year outcomes of surgical aortic valve replacement with a contemporary supra-annular porcine valve in a Medicare populationCentral MessagePerspective

JTCVS Open, 2022
Objective: Bioprosthetic surgical aortic valve replacement remains an important treatment option in the era of transcatheter interventions. Real-world outcomes are not well characterized because of limited prospective follow-up studies. We present the 10-
Robert J. Wiechmann, MD, Leonard Y. Lee, MD, Yang Yu, PhD, Julie B. Prillinger, PhD, Dan Gutfinger, MD, Bradford Blakeman, MD   +5 more
doaj   +1 more source

Leucine‐Dependent SLC7A5–PGAM5 Interaction Promotes Advanced Atherosclerosis Through Hindering Mitochondrial Function of Macrophages

Advanced Science, EarlyView.
Higher plasma leucine is associated with increased risk of new‐onset myocardial infarction. Leucine deprivation alleviates advanced atherosclerosis in mice. Tumor‐induced leucine deprivation reprograms macrophage metabolism and increases CD5Lhi macrophages in mouse plaques. Mechanistically, leucine deficiency reduced SLC7A5‐PGAM5 binding in macrophages,
Shan Zhong, Xueyu Wang, Qingsong Li, Siqi Wang, Bin Sun, Wenjun Ni, Gengyu Zhou, Fan Wang, Xianwei Xie, Cheng Jin, Gang Xu, Peng Zhao, Xiang Peng, Feiyuan Han, Xiangwen Xi, Yidan Wang, Juan Xu, Yue Wang, Xia Gu, Shuo Li, Jian Zhang, Shuijie Li, Jinwei Tian   +22 more
wiley   +1 more source

Perioperative Outcomes After Bioprosthetic Valve Replacement in Patients Sensitized to Alpha-Gal

Annals of Thoracic Surgery Short Reports
Background: Alpha-gal syndrome from tick bites, due to sensitivity to alpha-gal, can cause severe allergies. Heart valve implants contain alpha-gal, yet alpha-gal syndrome screening is not standard before valve replacement.
Berk Aykut, MD, Hoe King Lim, BEng, Smith M. Ngeve, BA, Anna Hoover, BS, Cathlyn K. Medina, BA, Jacob Scherba, BS, Ashley Menken, BS, Douglas M. Overbey, MD, MPH, Tariq M. Omer, MS, Scott P. Commins, MD, PhD, Joseph R. Nellis, MD, MBA, Joseph W. Turek, MD, PhD   +11 more
doaj   +1 more source

Double cardiac pseudoaneurysm in a postoperative patient

Türk Kardiyoloji Derneği Arşivi, 2015
A mitral-aortic intervalvular fibrosa pseudoaneurysm is a rare complication after aortic and mitral valve replacement and aortic root replacement. A left ventricular pseudoaneurysm after mitral valve replacement is also a rare complication.
Tahereh Davarpasand, Ali Hosseinsabet
doaj   +1 more source

Building an Intelligent Cardiovascular System Platform: Embedding Artificial Intelligence across All Facets of Cardiovascular Medicine

Advanced Intelligent Systems, EarlyView.
This paper presents an integrated AI‐driven cardiovascular platform unifying multimodal data, predictive analytics, and real‐time monitoring. It demonstrates how artificial intelligence—from deep learning to federated learning—enables early diagnosis, precision treatment, and personalized rehabilitation across the full disease lifecycle, promoting a ...
Mowei Kong, Xingwei Zhao, Qiuting Li, Yang Yu, Chunxiang Zhang   +4 more
wiley   +1 more source

Predicting pressure gradient using artificial intelligence for transcatheter aortic valve replacementCentral MessagePerspective

JTCVS Techniques
Objective: After transcatheter aortic valve replacement, the mean transvalvular pressure gradient indicates the effectiveness of the therapy. The objective is to develop artificial intelligence to predict the post–transcatheter aortic valve replacement ...
Anoushka Dasi, BS, Beom Lee, MS, Venkateshwar Polsani, MD, FACC, FASE, Pradeep Yadav, MD, FACC, Lakshmi Prasad Dasi, PhD, FACC, FAIMBE, Vinod H. Thourani, MD, FACS, FACC   +5 more
doaj   +1 more source

Perceval S Sutureless Prosthesis in Aortic Valve Replacement

Неотложная медицинская помощь, 2019
BACKGROUND In 12–47% of patients, there is a need to repeat the aortic valve replacement due to various valve-related complications in the immediate and late postoperative period.
V. V. Sokolov, A. I. Kovalyov, V. V. Vladimirov, I. V. Ivanov, N. M. Bikbova   +4 more
doaj   +1 more source