Results 221 to 230 of about 269,298 (386)

Secukinumab in the Treatment of Moderate‐to‐Severe Hidradenitis Suppurativa: Pooled Pharmacokinetics and Safety Results From the SUNSHINE and SUNRISE Phase 3 Studies

open access: yesInternational Journal of Dermatology, EarlyView.
ABSTRACT Background Secukinumab, a fully human, monoclonal antibody targeting interleukin‐17A, is approved for moderate‐to‐severe HS in adults. This study evaluated pharmacokinetics (PK), high‐sensitivity C‐reactive protein (hsCRP) changes, and safety of secukinumab over 52 weeks in SUNSHINE and SUNRISE Phase 3 trials.
Afsaneh Alavi   +13 more
wiley   +1 more source

Transcatheter Treatment of Bicuspid Aortic Valve Stenosis: From Observational Studies to Randomized Clinical Trials. [PDF]

open access: yesStruct Heart
Samim D   +8 more
europepmc   +1 more source

A Descriptive Qualitative Study of Patient and Carer Perspectives on the Acceptability of Transcatheter Aortic Valve Implantation

open access: yesJournal of Advanced Nursing, EarlyView.
ABSTRACT Aim To provide a structured analysis of the acceptability of transcatheter aortic valve implantation to support clinical conversations, decision making and recovery for older adults with aortic stenosis and their carers. Background While transcatheter aortic valve implantation is an effective treatment for heart valve disease, its ...
Nicola Straiton   +2 more
wiley   +1 more source

Epigenetic dysregulation of energy homeostasis drives aortic valve stenosis that is treatable with metformin. [PDF]

open access: yesJCI Insight
Cashman TJ   +8 more
europepmc   +1 more source

Self-expanding transcatheter aortic valve replacement using alternative access sites in symptomatic patients with severe aortic stenosis deemed extreme risk of surgery [PDF]

open access: bronze, 2014
Michael J. Reardon   +26 more
openalex   +1 more source

Staging Cardiac Damage in Patients With Asymptomatic Aortic Valve Stenosis.

open access: yesJournal of the American College of Cardiology, 2019
L. Tastet   +17 more
semanticscholar   +1 more source

Efficacy of a Multicomponent Intervention for Frailty or Physical Function in Prefrail or Frail Older Adults: FRAILMERIT Multicenter Clinical Trial

open access: yesJournal of the American Geriatrics Society, EarlyView.
Clinical management of the older adult. ABSTRACT Objectives Frailty is a common condition in community‐dwelling older adults with high health and socioeconomic implications. However, primary care‐led randomized trials have been scarcely tested. Design Multicenter cluster randomized clinical trial.
Adriana Abizanda Saro   +86 more
wiley   +1 more source

Aortic valve stenosis and osteoporosis: insights from a mouse model. [PDF]

open access: yesBMC Cardiovasc Disord
Billig H   +14 more
europepmc   +1 more source

Activated platelets promote an osteogenic programme and the progression of calcific aortic valve stenosis

open access: yesEuropean Heart Journal, 2019
R. Bouchareb   +12 more
semanticscholar   +1 more source

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