Results 271 to 280 of about 112,118 (358)

Cardiovascular Health in Women—Across the Lifespan

open access: yesClinical Endocrinology, EarlyView.
ABSTRACT Cardiovascular disease (CVD) remains the leading cause of mortality and morbidity among women worldwide. However, CVD continues to be perceived as a predominantly male issue. CVD in women therefore remains understudied, underrecognized and undertreated.
Jaya Chandrasekhar   +5 more
wiley   +1 more source

A Novel Intronic Variant in the KH3 Domain of HNRNPK Leads to a Mild Form of Au‐Kline Syndrome

open access: yesClinical Genetics, EarlyView.
Integrated genomic and epigenomic analyses, associated with functional studies, confirm the pathogenicity of a novel HNRNPK variant in Au‐Kline syndrome (AKS). Our study underscores the value of DNA methylation signatures in variant interpretation, enhancing accurate diagnosis and clinical management of rare neurodevelopmental disorders.
Maura Mingoia   +16 more
wiley   +1 more source

Secukinumab in the Treatment of Moderate‐to‐Severe Hidradenitis Suppurativa: Pooled Pharmacokinetics and Safety Results From the SUNSHINE and SUNRISE Phase 3 Studies

open access: yesInternational Journal of Dermatology, EarlyView.
ABSTRACT Background Secukinumab, a fully human, monoclonal antibody targeting interleukin‐17A, is approved for moderate‐to‐severe HS in adults. This study evaluated pharmacokinetics (PK), high‐sensitivity C‐reactive protein (hsCRP) changes, and safety of secukinumab over 52 weeks in SUNSHINE and SUNRISE Phase 3 trials.
Afsaneh Alavi   +13 more
wiley   +1 more source

Defining the scope of point‐of‐care ultrasound in internal medicine: a consensus statement by the point‐of‐care special interest group of the Internal Medicine Society of Australia and New Zealand

open access: yesInternal Medicine Journal, EarlyView.
Abstract Background Point‐of‐care ultrasound (POCUS) complements physical examination to advance diagnosis and treatment in a range of clinical scenarios. However, the scope for adult internal medicine physicians is not defined in Australia and New Zealand.
Ximena Cid‐Serra   +11 more
wiley   +1 more source

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