Results 21 to 30 of about 64,504 (248)

Rapid progression of aortic stenosis in a 3-month-old infant with bicuspid aortic valve and DeSanto-Shinawi syndrome

Annals of Pediatric Cardiology, 2021
A 3-month-old female was diagnosed at 1 month of age with DeSanto-Shinawi syndrome (DSS) and bicuspid aortic valve with trivial stenosis. The aortic valve stenosis progressed to severe within 2 months and required balloon aortic valvuloplasty.
Daiji Takajo, Ghadir Katato, Sanjeev Aggarwal   +2 more
doaj   +1 more source

Statins for progression of aortic valve stenosis and the best evidence for making decisions in health care

São Paulo Medical Journal, 2011
In the Western world, calcified aortic valve stenosis is the most common form of valvular heart disease, affecting up to 3% of adults over the age of 75 years.
Luciana Thiago, Selma Rumiko Tsuj, Álvaro Nagib Atallah, Maria Eduarda dos Santos Puga, Aécio Flávio Teixeira de Góis   +4 more
doaj   +1 more source

Vorticity‐Facilitated Platelet Aggregation: a High Expansion‐Ratio Stenotic Microfluidic Platform Unravels the Role of Complex Flow Dynamics in Arterial Thrombosis

Advanced Healthcare Materials, EarlyView.
This study reveals how vorticity—a swirling flow pattern—enhances platelet aggregation and thrombus formation in high‐shear conditions. Using a custom microfluidic model, it is shows that vorticity promotes vWF–GPIbα interactions and calcium signaling, providing new insights into thrombosis mechanobiology and informing safer blood‐contacting medical ...
Jianfang Ren, Nurul Aisha Zainal Abidin, Allan Sun, Rui Gao, Yuxin Chen, Arian Nasser, Zihao Wang, Yunduo Charles Zhao, Alexander Dupuy, Anna Waterhouse, Qian Peter Su, Daniele Vigolo, Mike Chia Lun Wu, Lining Arnold Ju   +13 more
wiley   +1 more source

Unicuspid Aortic Stenosis in a Patient with Turner Syndrome: A Case Report

Frontiers in Cardiovascular Medicine, 2014
Congenital aortic valve anomalies are the cause of premature aortic stenosis in pediatric and younger adult populations. Despite being very rare, unicuspid aortic valves account for approximately 5% of isolated aortic valve replacements.
Michael eEssandoh, Karina eCastellon-Larios, Alix eZuleta-Alarcon, Juan Guillermo Portillo, Juan A Crestanello   +4 more
doaj   +1 more source

Transcatheter versus surgical aortic valve replacement for stenotic bicuspid aortic valve: Systematic review and meta-analysisCentral MessagePerspective

JTCVS Open, 2023
Objectives: Bicuspid aortic valves have been excluded from randomized trials comparing transcatheter aortic valve replacement with surgical aortic valve replacement.
Yosuke Sakurai, MD, Yujiro Yokoyama, MD, Toshiki Kuno, MD, PhD, Hisato Takagi, MD, PhD, Amgad Mentias, MD, Vinod H. Thourani, MD, Azeem Latib, MD, Tsuyoshi Kaneko, MD   +7 more
doaj   +1 more source

PIEZO Force Sensing in Vascular Biology: An Explosion of New Knowledge, Concepts and Opportunity

Advanced Science, EarlyView.
Knowledge of the remarkable mechanical force sensing and electrically transducing PIEZO1 and PIEZO2 channels is discussed across vascular biology and its cell types from the embryonic to adult stages in health, disease and old age. How the channels work, relate to other factors and signal for tissue responses to mechanical forces is debated.
David J Beech
wiley   +1 more source

Truncating Variants in RREB1 Cause a Novel RASopathy Syndrome of Congenital Heart Disease, Genitourinary Malformations, and Developmental Delay

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The interstitial 6p microdeletion syndrome is characterized by dysmorphic facies and structural heart, kidney, brain, and musculoskeletal differences. RREB1 haploinsufficiency and consequent abnormal RAS‐MAPK pathway signaling have been proposed as a driver of the disease phenotype; however, apart from a single case report, the phenotype of ...
Alanna Strong, Caoimhe McKenna, Karen Stals, Antonio Vitobello, Mathilde Renaud, Claudine Rieubland, Michel Guipponi, Christophe Philippe, Paul Vrana, Alisa Gaskell, A. Micheil Innes, Alyssa L. Rippert, Rebecca Ahrens‐Nicklas, Elizabeth Bhoj, Kiersten Keller, Bimal P. Chaudhari, Brandon S. Stone   +16 more
wiley   +1 more source

One-stop transcatheter aortic valve replacement and fenestrated endovascular aortic aneurysm repair: A case report

Radiology Case Reports
The management of patients with severe aortic valve stenosis and an abdominal aortic aneurysm is a real therapeutic challenge. Minimally invasive treatment is more beneficial than open surgery for treating both aortic valve stenosis and abdominal aortic ...
Abderrahim Sanoussi, MD, Adel Aminian, MD, Jâd Abi-Khalil, MD   +2 more
doaj   +1 more source

POSSIBILITIES OF INTERVENTIONAL CORRECTION OF CRITICAL AORTIC STENOSIS: CONTEMPORARY STATE OF PROBLEM AND PERSPECTIVES

Креативная хирургия и онкология, 2017
The paper studies the issues of aortic stenosis etiology and pathogenesis, clinical assessment of severity based on the distinct symptoms of decompensated aortic defect and echocardiographic measures, and modern methods of aortic stenosis correction ...
S. A. Amzaev, A. S. Sergeev, V. K. Sukhov, E. A. Shloydo, A. G. Obrezan   +4 more
doaj   +1 more source

AP2M1 Is a Candidate Gene for Microcephaly and Intellectual Disability in 3q27.1 Deletions

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Deletions of the 3q26.33q27.2 region appear to correlate with a distinct phenotype, although there are few reported cases. Here, we present seven previously unreported individuals carrying de novo 3q27 deletions (under 5 Mb), which include the AP2M1 (adaptor‐related protein complex 2, mu‐1 subunit) gene and summarize data from 12 previously ...
Russell Gear, Paul Kalitsis, Melissa Glass, Bertrand Isidor, Catherine Vincent‐Delorme, Florence Petit, Judith M. A. Verhagen, Alexander Jorge, Ana Cristina Victorino Krepischi, Ikeoluwa Osei‐Owusu, Eva Martinez, Anne O'Donnell‐Luria, Nicole de Leeuw, Sarah Ruggiero, Ingo Helbig, Francis David I, Natasha J. Brown   +16 more
wiley   +1 more source