Results 61 to 70 of about 873,650 (292)
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Short time light variations of Ap-stars [PDF]
International Astronomical Union Colloquium, 1986 Prom 1973 till 1981 sixteen Ap stars were investigated regarding to short time light variations with the twin telescope of the Zentralinstitut für Astrophysik stationed at the observatory Shemahka of the Academy of Science of Aserbaidshan. Only five of these stars show significant varyations with characteristical times in the region of 0.5 to 5 houres ...
G. Hildebrandt +4 more
openaire +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Super-slowly rotating Ap (ssrAp) stars: Spectroscopic study [PDF]
To gain better understanding of the Ap stars with the longest rotation periods, we obtained high resolution spectra of a sample of super-slowly rotating Ap (ssrAp) star candidates identified by a TESS photometric survey, to confirm that they are indeed ...
Giarrusso, M. +5 more
core +4 more sources
Magnetoacoustic oscillations in Ap stars [PDF]
Proceedings of the International Astronomical Union, 2009 AbstractIn this paper I briefly summarize a number of robust results derived from observational and theoretical studies of roAp stars over the past three decades.
openaire +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
, 1998 Certain problems in the field of stellar atmospheres, polarized radiative transfer and magnetic field diagnostics cannot be addressed by means of traditional sequential programming techniques because CPU times become prohibitive on even the fastest single processor machines when realistic physics and accurate numerical methods are employed.
openaire +2 more sources
$\Delta a$ and Strömgren photometry of stars in the Renson-catalogue of Ap and Am stars [PDF]
Astronomy and Astrophysics Supplement Series, 1998 We have observed 131 stars of Renson's (1991) catalogue of Ap and Am stars both in the Stromgren & Maitzen's (1976) ?a system as a contribution to the photometric studies of the ?5200 broad band flux depression feature in chemically peculiar stars.
Maitzen, Hans Michael +2 more
openaire +2 more sources
Strongly magnetic Ap stars in the
, 2019 Context. Knowing the distribution of strongly magnetic Ap stars in the Hertzsprung-Russell diagram (HRD) allows us to study the evolution of their magnetic fields across the main sequence (MS).
R.-D. Scholz +2 more
core +1 more source
Molecular Oncology, EarlyView.Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis +20 more
wiley +1 more source